Structures and luminescent properties of four compounds based on binuclear metal-terpyridine building blocks

<p>Four new coordination polymers, [Cd(3-TPTP)Cl]₂ (3-HTPTP = 4′-(3-tetrazolylphenyl)2,2′:6′2′′-terpyridine, <b>1</b>), <b>{</b>[Cd(3-TPTP)(<i>p</i>BDC)_0.5]∙4H₂O}_n (<i>p</i>H₂BDC = 1,4-benzenedicarboxylic acid, <b>2</b>), {[Mn(3-TPTP)(<i>m</i>BDC)_0.5]∙5H₂O}_n (<i>m</i>H₂BDC = 1,3-benzenedicarboxylic acid, <b>3</b>), and [Pb(3-TPTP)(H₂O)₂]∙OH (<b>4</b>), were obtained. Compounds <b>1</b>–<b>3</b> are composed of binuclear [M₂(3-TPTP)₂] ring as building unit. In <b>1</b>, the binuclear rings pack into a 3-D supramolecular framework via various hydrogen bonds. In <b>2</b> and <b>3</b>, the binuclear rings are connected by <i>m</i>BDC²⁻ and <i>p</i>BDC²⁻, respectively, resulting in two types of 1-D chains. In <b>4</b>, the mononuclear [Pb(3-TPTP)] units are connected by Pb⋯N weak interactions, giving a chiral 1-D coordination chain, which is further connected by O–H⋯N interaction to form a chiral 3-D supramolecular framework. The phase purity of <b>1</b>–<b>4</b> and luminescence properties of <b>1</b>, <b>2</b>, and <b>4</b> were also investigated.</p

Stereocontrolled Construction of Tetrahydro­pyrano­[2,3‑<i>c</i>]pyrazole Scaffold via an Organocatalyzed Formal [3 + 3] Annulation

A bifunctional squaramide catalyzed enantioselective formal [3 + 3] annulation reaction with pyrazolin-5-ones and nitroallylic acetates has been developed. Densely substituted tetrahydro­pyrano­[2,3-<i>c</i>]­pyrazoles with two adjacent stereogenic centers are obtained in a highly stereocontrolled manner. Representative transformation of the annulation product to a biologically important fused dihydroisoquinoline is achieved without any appreciable loss in the diastereo- and enantioselectivity

Additional file 1: Figure S1. of Endothelial bioreactor system ameliorates multiple organ dysfunction in septic rats

The endothelial bioreactor (EBR) had no effect on the levels of T lymphocytes in septic rats. Circulating and splenic levels of CD4+ helper T cells, CD8+ cytotoxic T cells, and CD4+ CD25+ Foxp3+ T regulatory cells were analyzed by flow cytometer at 72 h after CLP (n = 7–9 per group). EBR = endothelial bioreactor; CLP = cecal ligation and puncture. (TIF 307 kb

The mean measured and predicted systemic citrate concentrations with 95% confidence intervals at 1 h, 3 h, 6 h and 8 h (vertical lines).

<p>The mean measured and predicted systemic citrate concentrations with 95% confidence intervals at 1 h, 3 h, 6 h and 8 h (vertical lines).</p

The demographic and baseline laboratory parameters of patient group and healthy volunteer group.

<p>ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen.</p><p>Data are represented as mean ± SD or median with interquartile range.</p

Clinical characteristics of patients involved in the citrate pharmacokinetics study.

<p>Clinical characteristics of patients involved in the citrate pharmacokinetics study.</p

Plasma citrate concentrations (mean ± SD) during 120 min citrate infusion and 120 min after the end of citrate infusion in critically ill patients with AKI (n = 12) and in healthy volunteers (n = 12).

<p>Plasma citrate concentrations (mean ± SD) during 120 min citrate infusion and 120 min after the end of citrate infusion in critically ill patients with AKI (n = 12) and in healthy volunteers (n = 12).</p

Measured citrate and ionized calcium curves during the first 8 hours of CVVH using citrate anticoagulation while the blood rate were set at 150–200 ml/min and the substitution fluid were at the rate of 4 L/h (n = 10 treatments).

<p>Measured citrate and ionized calcium curves during the first 8 hours of CVVH using citrate anticoagulation while the blood rate were set at 150–200 ml/min and the substitution fluid were at the rate of 4 L/h (n = 10 treatments).</p