Table_1_A health economic analysis of an integrated diabetes care program in China: based on real-world evidence.DOCX

IntroductionAn integrated care program was set up in China to improve the collaboration between primary healthcare centers and hospitals on diabetes management. This study aims to evaluate the economic value of this program with real-world data and to examine whether it can be promoted in primary healthcare settings in China.MethodsThis integrated diabetes care program was implemented in Yuhuan City, China, to coordinate primary care and specialty care, treatment and prevention services, as well as the responsibilities of doctors and nurses. Cost-effectiveness analysis was used to compare the short-term economic value of this program (intervention group) versus usual diabetes management (control group). The cost data were collected from a societal perspective, while the effectiveness indicators pointed to the improvement of control rates of fasting blood glucose (FBG), systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels after the 1 year intervention. In addition, cost-utility analysis was applied to evaluate the long-term value of the two groups. Patients’ long-term diabetes management costs and quality-adjusted life years (QALYs) were simulated by the United Kingdom Prospective Diabetes Study Outcomes Model 2.ResultsThe results showed that for 1% FBG, SPB, and DBP control rate improvement, the costs for the intervention group were 290.53, 124.39, and 249.15 Chinese Yuan (CNY), respectively, while the corresponding costs for the control group were 655.19, 610.43, and 1460.25 CNY. Thus, the intervention group’s cost-effectiveness ratios were lower than those of the control group. In addition, compared to the control group, the intervention group’s incremental costs per QALY improvement were 102.67 thousand CNY, which means that the intervention was cost-effective according to the World Health Organization’s standards.DiscussionIn conclusion, this study suggested that this integrated diabetes care program created short-term and long-term economic values through patient self-management support, primary care strengthening, and care coordination. As this program followed the principles of integrated care reform, it can be promoted in China. Also, its elements can provide valuable experience for other researchers to build customized integrated care models.</p

Additional file 1: of High-performance gene expression and knockout tools using sleeping beauty transposon system

Figure S1. Re-expression of Flag-tagged RCC2 rescued sgRCC2-mediated delay of mitotic exit. A. HeLa cells expressing GFP-H2B were incubated with Nocodazole (100 ng/ml) or Taxol (2 μM) for 12 h, and analyzed using ZEISS710 confocal microscope. (Scale bars, 2 μm). B. Immunoblots for control cells, RCC2-depleted cells, and RCC2-depleted cells stably expressing the indicated constructs. C. Time-lapse images showing mitotic exit in HeLa-H2B cells indicated above. Figure S2. Depletion of BRD7 delays mitotic exit and leads to spindle misorientation in HeLa cells. A. HeLa cells transfected with indicated sgRNA and synchronized in M phase by incubation with 100 ng/ml nocodazole for 14 h. M phase cells selected by shake-off were released for the indicated time. B. Time-lapse images showing prolonged metaphase to anaphase and misoriented cell division (uneven timing of daughter-cell adhesion to the substratum) in BRD7-depleted HeLa-H2B cells, compared with control. (Scale bars, 2 μm). (DOCX 7450 kb

Graphene-Impregnated Paper-Based Electronic Skins for Robotic Intelligence and Wireless Health Monitoring

Due to favorable electrical, mechanical, and stability properties of two-dimensional graphene (G), electronic skins (E-skins) were fabricated here based on G-impregnated paper (G-I paper) and interdigitated electrodes (IDEs), and multiple signals could be successfully detected, including pressure and humidity. The pressure-sensitive (P-S) E-skin showed a relatively large pressure detection range of 0–18.9 kPa, and its GF values were 0.96 and 0.44 kPa–1 with ranges of 1.5 × 10–2–7.2 and 7.2–18.9 kPa, respectively. For the humidity-sensitive (H-S) E-skin, its GF values were 2.62 × 10–2 and 0.55 with RH ranges of 25–45 and 45–95%, respectively. In addition, the prepared E-skins were applied in the fields of intelligent robotics and wearable devices. Robotic intelligence and wireless health monitoring were successfully realized

Graphene-Impregnated Paper-Based Electronic Skins for Robotic Intelligence and Wireless Health Monitoring

Due to favorable electrical, mechanical, and stability properties of two-dimensional graphene (G), electronic skins (E-skins) were fabricated here based on G-impregnated paper (G-I paper) and interdigitated electrodes (IDEs), and multiple signals could be successfully detected, including pressure and humidity. The pressure-sensitive (P-S) E-skin showed a relatively large pressure detection range of 0–18.9 kPa, and its GF values were 0.96 and 0.44 kPa–1 with ranges of 1.5 × 10–2–7.2 and 7.2–18.9 kPa, respectively. For the humidity-sensitive (H-S) E-skin, its GF values were 2.62 × 10–2 and 0.55 with RH ranges of 25–45 and 45–95%, respectively. In addition, the prepared E-skins were applied in the fields of intelligent robotics and wearable devices. Robotic intelligence and wireless health monitoring were successfully realized

Graphene-Impregnated Paper-Based Electronic Skins for Robotic Intelligence and Wireless Health Monitoring

Due to favorable electrical, mechanical, and stability properties of two-dimensional graphene (G), electronic skins (E-skins) were fabricated here based on G-impregnated paper (G-I paper) and interdigitated electrodes (IDEs), and multiple signals could be successfully detected, including pressure and humidity. The pressure-sensitive (P-S) E-skin showed a relatively large pressure detection range of 0–18.9 kPa, and its GF values were 0.96 and 0.44 kPa–1 with ranges of 1.5 × 10–2–7.2 and 7.2–18.9 kPa, respectively. For the humidity-sensitive (H-S) E-skin, its GF values were 2.62 × 10–2 and 0.55 with RH ranges of 25–45 and 45–95%, respectively. In addition, the prepared E-skins were applied in the fields of intelligent robotics and wearable devices. Robotic intelligence and wireless health monitoring were successfully realized

Flexible, Wearable, and Ultralow-Power-Consumption Electronic Skins Based on a Thermally Reduced Graphene Oxide/Carbon Nanotube Composite Film

Based on a thermally reduced graphene oxide (rGO)/carbon nanotube (CNT) composite film, two kinds of flexible, wearable, and ultralow-power-consumption electronic skins (E-skins) are prepared. They have been used to successfully perceive the signals of stretch, flexion, temperature, and pressure, and their gauge factors (GFs) are 233, 2.37 rad–1, 5.53 × 10–4 °C–1, and 1.58 kPa–1, as the mass fraction of graphene is 20% in the composite film. Compared with the E-skins based on pure rGO film, our E-skins have larger stretching stain (ε) and bending angle (θ) ranges and higher temperature- and pressure-based GF values. Furthermore, the prepared E-skins have been successfully applied in various fields, and their ultralow power consumption has also been confirmed to be below 72 nW in wearable device applications

Flexible, Wearable, and Ultralow-Power-Consumption Electronic Skins Based on a Thermally Reduced Graphene Oxide/Carbon Nanotube Composite Film

Based on a thermally reduced graphene oxide (rGO)/carbon nanotube (CNT) composite film, two kinds of flexible, wearable, and ultralow-power-consumption electronic skins (E-skins) are prepared. They have been used to successfully perceive the signals of stretch, flexion, temperature, and pressure, and their gauge factors (GFs) are 233, 2.37 rad–1, 5.53 × 10–4 °C–1, and 1.58 kPa–1, as the mass fraction of graphene is 20% in the composite film. Compared with the E-skins based on pure rGO film, our E-skins have larger stretching stain (ε) and bending angle (θ) ranges and higher temperature- and pressure-based GF values. Furthermore, the prepared E-skins have been successfully applied in various fields, and their ultralow power consumption has also been confirmed to be below 72 nW in wearable device applications

Graphene-Impregnated Paper-Based Electronic Skins for Robotic Intelligence and Wireless Health Monitoring

Due to favorable electrical, mechanical, and stability properties of two-dimensional graphene (G), electronic skins (E-skins) were fabricated here based on G-impregnated paper (G-I paper) and interdigitated electrodes (IDEs), and multiple signals could be successfully detected, including pressure and humidity. The pressure-sensitive (P-S) E-skin showed a relatively large pressure detection range of 0–18.9 kPa, and its GF values were 0.96 and 0.44 kPa–1 with ranges of 1.5 × 10–2–7.2 and 7.2–18.9 kPa, respectively. For the humidity-sensitive (H-S) E-skin, its GF values were 2.62 × 10–2 and 0.55 with RH ranges of 25–45 and 45–95%, respectively. In addition, the prepared E-skins were applied in the fields of intelligent robotics and wearable devices. Robotic intelligence and wireless health monitoring were successfully realized

Flexible, Wearable, and Ultralow-Power-Consumption Electronic Skins Based on a Thermally Reduced Graphene Oxide/Carbon Nanotube Composite Film

Based on a thermally reduced graphene oxide (rGO)/carbon nanotube (CNT) composite film, two kinds of flexible, wearable, and ultralow-power-consumption electronic skins (E-skins) are prepared. They have been used to successfully perceive the signals of stretch, flexion, temperature, and pressure, and their gauge factors (GFs) are 233, 2.37 rad–1, 5.53 × 10–4 °C–1, and 1.58 kPa–1, as the mass fraction of graphene is 20% in the composite film. Compared with the E-skins based on pure rGO film, our E-skins have larger stretching stain (ε) and bending angle (θ) ranges and higher temperature- and pressure-based GF values. Furthermore, the prepared E-skins have been successfully applied in various fields, and their ultralow power consumption has also been confirmed to be below 72 nW in wearable device applications

Table_1_Relationship between self-care compliance, trust, and satisfaction among hypertensive patients in China.pdf

IntroductionHypertension is a growing public health concern worldwide. It is a leading risk factor for all-cause mortality and may lead to complications such as cardiovascular disease, stroke, and kidney failure. Poor compliance of hypertensive patients is one of the major barriers to controlling high blood pressure. Compliance is not ideal among Chinese patients, and increasing patient self-care compliance with hypertension is necessary.MethodsThis article analyzes the status of self-care compliance, trust, and satisfaction among Chinese hypertensive patients using cross-sectional data from Zhejiang Province. We use a multi-group structural equation model (MGSEM) to compare the interrelationships across genders.ResultsThe study's findings show that the average trust, satisfaction, and compliance scores are 3.92 ± 0.55, 3.98 ± 0.61, and 3.33 ± 0.41, respectively. Female patients exhibit higher average total scores for trust and compliance than male patients. The SEM results indicate that trust has a direct positive association with compliance [β = 0.242, 95% CI: (0.068, 0.402)] and satisfaction [β = 0.260, 95% CI: (0.145, 0.367)], while their satisfaction is not directly associated with compliance. The results of MGSEM show that trust has an indirect effect on compliance in the male group through satisfaction [β = 0.051, P DiscussionThis study reveals the mechanisms of self-care compliance, trust, and satisfaction among Chinese hypertensive patients. Its findings may serve as a reference for guiding primary healthcare providers to improve hypertension patients' compliance and implement gender-targeted health interventions.</p