sj-pdf-1-jso-10.1177_23971983231197268 – Supplemental material for Are there more acute cardiac hospitalizations in winter in patients with systemic sclerosis? An analysis from the National Inpatient Sample

Supplemental material, sj-pdf-1-jso-10.1177_23971983231197268 for Are there more acute cardiac hospitalizations in winter in patients with systemic sclerosis? An analysis from the National Inpatient Sample by Yiming Luo, Laura Ross, Jiayi Zheng and Elana J Bernstein in Journal of Scleroderma and Related Disorders</p

Characterization of the first complete chloroplast genome of <i>Amaranthus hybridus</i> (Caryophyllales: Amaranthaceae) with phylogenetic implications

In the present study, the complete chloroplast genome of Amaranthus hybridus was sequenced and assembled. The complete chloroplast genome of Amaranthus hybridus is 150,709 in size, with the GC content of 36.56%. The chloroplast genome of Amaranthus hybridus contained 86 protein-coding genes (PCGs), eight ribosomal RNA (rRNA) genes, and 37 transfer RNA (tRNA) genes. Phylogenetic analysis based on combined chloroplast gene dataset indicated that the Amaranthus hybridus exhibited a close relationship with A. hypochondriacus and A. caudatus.</p

Meta-analysis of the overall response rate in the PD-1 antibody monotherapy groups and the other treatment groups.

PD-1 antibody treatment was associated with a higher overall response rate.</p

Meta-analysis of the overall treatment-related adverse events associated with pembrolizumab.

<p>Subgroup analysis of patients treated with different doses of pembrolizumab revealed a dose-dependent increase in adverse events.</p

DataSheet1_Sedimentary CaCO3 Accumulation in the Deep West Pacific Ocean.pdf

Distribution of calcium carbonate (CaCO3) in marine sediment has been studied over the last century, and influence by multiple factors with regard to dissolution and dilution of sedimentary CaCO3 has long been established. There is still lack of quantification on the influence of those factors, so it remains elusive to determine which specific process is driving the down-core variation of CaCO3 content (wtCaCO3%) records. Here, based on a newly compiled CaCO3 data set and a carbonate model, depth-profiles of sedimentary wtCaCO3% from the West Pacific Ocean can be well illustrated, and influence from different factors on their distribution features can be quantified. The deep ocean circulation is found to largely shape the inter-basin disparity in sedimentary wtCaCO3% distribution between the equatorial regions (e.g., the Western Equatorial Pacific Ocean and the Central Pacific Ocean) and the north–west regions (the Philippine Sea and the Northwest Pacific Ocean) in our study region. Moreover, the slow carbonate dissolution rate in the deep Central Pacific Ocean guarantees better accumulation of CaCO3 at depth compared to that in other regions. However, enhanced dilution by non-carbonate materials of sedimentary CaCO3 on a topographic complex can potentially obstruct the dissolution profiles constituted by sedimentary wtCaCO3% in the pelagic ocean. The aforementioned assertion suggests that changes of wtCaCO3% accumulation in marine sediment in the West Pacific Ocean can be used to dictate past changes of the deep ocean circulation (2,500 to 3,000 m) in this area but constraint on the non-carbonate flux, especially on the topographic complex, should be necessary.</p

PD-1 Antibody Monotherapy for Malignant Melanoma: A Systematic Review and Meta-Analysis

<div><p>Antibodies targeting programmed death 1 (PD-1) help prevent tumor cells from escaping immune-mediated destruction. We conducted this systematic review and meta-analysis to gain insight into the efficacy of PD-1 antibodies for the treatment of melanoma. Five trials involving 2,828 adult patients were included in this meta-analysis. In patients with previously untreated or refractory melanoma, treatment with PD-1 antibodies significantly improved the six-month progression-free survival (PFS) (HR 0.55, 95% CI 0.50–0.60, P<0.00001) and the overall response rate (OR 3.89, 95% CI 3.12–4.83, P<0.00001). This meta-analysis indicated that anti-PD-1 treatment might provide a significant survival benefit in patients with melanoma. In addition, we found that patients treated with nivolumab reported significantly fewer treatment-related adverse events (OR 0.74, 95% CI 0.57–0.97, P = 0.03) than those treated with other agents, but there was a dose-dependent increase in the frequency of adverse events in patients treated with pembrolizumab.</p></div

Risk of bias graph.

<p>The overall risk of bias was rated as low in all eligible studies.</p

Meta-analysis of the overall treatment-related adverse events associated with nivolumab.

<p>Patients treated with nivolumab had a lower incidence of adverse events.</p

Descriptive summary of treatment-related adverse events.

<p>Descriptive summary of treatment-related adverse events.</p

Descriptive summary of the included patients and randomized trials.

<p>Descriptive summary of the included patients and randomized trials.</p