Integrin α_vβ₃‑Targeted C‑Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors

With a cocktail formulation of soybean milk as a green carbon source and TTDDA as a capping agent, integrin α_vβ₃-targeted C-dot nanocomposites (MB-CDs@NH-RGD) have been successfully fabricated via a facile microwaving protocol. Modification of the surface coating and RGD-conjugation endow their superior biocompatibility as well as highly specific targeting profile to α_vβ₃-overexpressed cell lines of MDA-MB231 and B16 as representative superficial malignant tumors. Meanwhile, the significant photothermal effect has been generated on irradiation of these targeted C-dot nanocomposites by a pulsed laser, which proved their eligibility for potential thermal ablation therapy. In vivo photoacoustic imaging using these C-dot nanocomposites as novel imaging probes verified their excellent targeting sensitivity and contrast enhancement. This exciting evidence implies a promising strategy to utilize them for multifunctional nanotheranostic purposes in combination with precision diagnosis and photothermal treatment against superficial malignant tumors

Comparison of the Kato-Katz methods and ELISA for diagnosis <i>Clonorchis sinensis</i> infection in Heilongjiang Province.

<p>The Kappa value between the two methods was 0.564, <i>P</i><0.001.</p

Prevalence of Clonorchis sinensis infection in different age group by Kato-Katz and ELISA examinations.

<p>Prevalence of Clonorchis sinensis infection in different age group by Kato-Katz and ELISA examinations.</p

Flowchart for the diagnosis of 2359 patients.

<p>KK = Kato-Katz technique.</p

Regional distribution of <i>Clonorchis sinensis</i> infection in Heilongjiang Province by Kato-Katz and ELISA examinations.

<p>A. by Kato-Katz B. by ELISA.</p

Test properties of the Kato-Katz methods and ELISA as estimated by Bayesian analysis.

*<p>CI, credibility intervals.</p

Supplemental Material - Knowledge, attitudes, and practices of Jamaican healthcare workers on nosocomial infection control

Supplemental Material for Knowledge, attitudes, and practices of Jamaican healthcare workers on nosocomial infection control by Pauline Jolly, Yihong Li, Avanelle Thomas, Andrew Braun, Luz Padilla, Symone Thompson, and Maung Aung in Journal of Infection Prevention.</p

Values of priors and corresponding beta distributions used to estimate the test parameters in the diagnosis of <i>Clonorchis sinensis</i>.

<p>Se = sensitivity.</p><p>Sp = specificity.</p

Prevalence of clonorchiasis in different patient populations.

<p>A. Gender. B. History of treatment. C. Environment. D. Occupation. E. Habit of eating raw fish. F. Season. <b>*</b>P<0.05, compared at the same time point of prevalence of <i>Clonorchis sinensis</i> infection in different patient populations. ﹟P<0.05, 2009 vs 2012, 2010 vs 2012, 2011 vs 2012; †p<0.05, 2009 vs 2012, 2010 vs 2012; § p<0.05, 2010 vs 2012, 2011 vs 2012; ☆p<0.05, 2011 vs 2012; ¶ p<0.05, 2009vs 2011, 2010 vs 2011; ‡p<0.05, 2010 vs 2011; ＆p<0.05, 2010vs 2009, 2011 vs 2009; ※p<0.05, 2010vs 2009, 2012vs 2009.</p

Adjusted odds ratios for gastric precancerous lesions in relation to selected periodontal pathogen DNA levels and stratified by periodontal disease severity¹.

<p>PD = Pocket Depth, CAL = Clinical Attachment Loss.</p>1<p>Cut-points for periodontal disease severity were determined at the median.</p>2<p>ORs estimated in relation to a standard deviation increase in the log-transformed bacterial DNA levels and adjusted for gender, age, race, smoking status, educational attainment, BMI, and <i>H. pylori</i> status.</p>3<p>Cumulative bacterial burden is a summary measure estimated by standardizing each bacterial DNA level (dividing each person-specific value by the log-transformed population standard deviation) and summing these values across all four species.</p>4<p>P-value for the cross-product term of each log-transformed bacterial DNA level and each periodontal index entered as continuous variables.</p