59 research outputs found

    Long-term effects of reclamation on A) SOC, B) TN, and C) TP of the coastal marsh.

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    <p>* and ** indicate significant difference at <i>p</i><0.05 and <i>p</i><0.01 level, respectively.</p

    Long-term influences of reclamation on stratification ratios of A) SOC, B) TN, and C) TP.

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    <p>* and ** indicate significant difference at <i>p</i><0.05 and <i>p</i><0.01 level, respectively.</p

    IL-17A activates NF-κB pathway in AGS cells.

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    <p>(A) Western blotting analysis was used to detect overall p50, p65, p52, c-Rel and RelB expression in AGS cells treated with IL-17A (50 ng/ml) at indicated time points. (B) Quantification of the protein levels of overall p50, p65, p52, c-Rel and RelB. (C) Western blotting analysis was used to detect nuclear p50, p65, p52, c-Rel and RelB expression in AGS cells treated with IL-17A (50 ng/mL) at indicated time points. (D) Quantification of the protein levels of nuclear p50, p65, p52, c-Rel and RelB. (E) The relative ratio of nuclear to overall fraction of p50, p65, p52, c-Rel and RelB. Values represent the means ± SD of three independent experiments performed in triplicate. **<i>p</i><0.01, compared with the control group.</p

    Long-term effects of reclamation on A) EC, B) salinity, and C) pH of coastal soils.

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    <p>* and ** indicate significant difference at <i>p</i><0.05 and <i>p</i><0.01 level, respectively.</p

    Nitrogen and phosphorus inputs of organic and chemical fertilizer applications in 2007 (source from the reference [24]).

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    <p>Nitrogen and phosphorus inputs of organic and chemical fertilizer applications in 2007 (source from the reference <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093727#pone.0093727-Zhu1" target="_blank">[24]</a>).</p

    Interleukin 17A Promotes Gastric Cancer Invasiveness via NF-κB Mediated Matrix Metalloproteinases 2 and 9 Expression

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    <div><p>Interleukin 17A (IL-17A), as a pro-inflammatory cytokine, is involved in pathology of inflammatory diseases and tumor microenvironment. The aim of this study is to investigate the effect of IL-17A on the invasiveness of gastric cancer (GC). In the study, we found that IL-17A could promote the migration and invasion of GC cells. Furthermore, after treated with IL-17A, the expressions and activities of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated, while the expressions of TIMP-1 and TIMP-2 were downregulated. Moreover, the nuclear/overall fractions of p65 and p50 were dramatically elevated by IL-17A. Pretreatment with helenalin, a nuclear factor-κB (NF-κB) inhibitor, was proved to abolish the promoting effect of IL-17A on the invasion ability of GC cells and upregulation of MMP-2 and MMP-9. In conclusion, our findings illustrated that IL-17A could promote the invasion of GC cells by activating NF-κB pathway, and subsequently upregulating the expression of MMP-2 and MMP-9. These results may lead to the identification of new diagnostic markers and therapeutic targets of GC.</p></div

    Long-term effects of agricultural cultivation on the compositions of A) cations and B) anions.

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    <p>Long-term effects of agricultural cultivation on the compositions of A) cations and B) anions.</p

    Organic and chemical fertilizer applications during 1950s–1990s (source from the reference [23]).

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    <p>Organic and chemical fertilizer applications during 1950s–1990s (source from the reference <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093727#pone.0093727-Liu1" target="_blank">[23]</a>).</p

    IL-17A promotes gastric cancer cell migration and invasion.

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    <p>(A) IL-17A treated GC cells (AGS, BGC-823 and SGC-7901) showed higher motility in a wound-healing assay, compared with cells without IL-17A treatment. (B) The percent migration rate is expressed as a percentage of the beginning area. (C) Effect of IL-17A on cell invasion was detected by transwell assay. Representative pictures of cells migrated through Matrigel-coated transwell were shown. (D) Total invasive cell number in each chamber was summarized as a percentage of control. Values represent the means ± SD of three independent experiments performed in triplicate. *<i>p</i><0.05 and **<i>p</i><0.01 compared with the control group.</p
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