1 research outputs found
Naphthomycins L–N, Ansamycin Antibiotics from <i>Streptomyces</i> sp. CS
Previous analyses of the naphthomycin biosynthetic gene
cluster
and a comparison with known naphthomycin-type products from <i>Streptomyces</i> sp. CS have suggested that new products can
be found from this strain. In this study, screening by LC-MS of <i>Streptomyces</i> sp. CS products formed under different culture
conditions revealed several unknown peaks in the product spectra of
extracts derived from oatmeal medium cultures. Three new naphthomycins,
naphthomycins L (<b>1</b>), M (<b>2</b>), and N (<b>3</b>), and the known naphthomycins A (<b>4</b>), E (<b>5</b>), and D (<b>6</b>) were obtained. The structures were
elucidated using spectroscopic data from 1D and 2D NMR and HRESIMS
experiments