Tabernacles of the Spirit

In the classic tradition of the exploratory essay, George Gammack examines the theme of community in this paper. He details varied aspects of the creation of community among those who are retired, taking as its focus the Men’s Sheds movement. The paper explores the relationship between persons and community in later years, looking in particular at how those with a lifetime’s worth of skills and knowledge can continue to contribute to the life of a community. Along the way we are introduced to the work of authors such as Charles Taylor, Richard Niebuhr, Primo Levi, Seamus Heaney and Richard Sennett on the subject of work and what comes after it.Publisher PD

Demographic data and clinical characteristics of the study subjects.

Demographic data and clinical characteristics of the study subjects.</p

Cumulative incidence of atrial fibrillation or flutter rates in patients with periodontitis and in individuals without periodontitis.

Cumulative incidence of atrial fibrillation or flutter rates in patients with periodontitis and in individuals without periodontitis.</p

Risk of Atrial Fibrillation or Flutter Associated with Periodontitis: A Nationwide, Population-Based, Cohort Study

<div><p>Objective</p><p>To investigate the risk of atrial fibrillation or atrial flutter in patients with periodontitis (PD) in comparison with individuals without PD.</p><p>Methods</p><p>We used the 1999–2010 Taiwanese National Health Insurance Research Database to identify cases of PD in the year 2000 matching (1:1) with persons without PD during 1999–2000 according to sex and individual age as the control group. Using Cox proportional regression analysis adjusting for potential confounders, including age, sex, and comorbidities at baseline, and average annual number of ambulatory visits and dental scaling frequency during the follow-up period, we estimated hazard ratios (HRs) with 95% confidence intervals (CIs) to examine the risk of atrial fibrillation or flutter in PD patients in comparison with the control group. Subgroup analyses according to age, gender, or comorbidities were conducted to study the robustness of the association and investigate possible interaction effects.</p><p>Results</p><p>We enrolled 393,745 patients with PD and 393,745 non-PD individuals. The incidence rates of atrial fibrillation or flutter were 200 per 10⁵ years among the PD group and 181 per 10⁵ years in the non-PD group (incidence rate ratio, 1.10; 95% CI, 1.06–1.14). After adjusting for potential confounders, we found an increased risk of atrial fibrillation or flutter in the PD group compared with the non-PD group (HR, 1.31; 95% CI, 1.25–1.36). The greater risk of atrial fibrillation or flutter in the PD group remained significant across all disease subgroups except hyperthyroidism and sleep apnea.</p><p>Conclusion</p><p>The present study results indicate an increased risk of atrial fibrillation or flutter in patients with PD. Lack of individual information about alcohol consumption, obesity, and tobacco use was a major limitation.</p></div

Univariate and multivariate analyses of the risk of atrial fibrillation or flutter associated with each variable shown as hazard ratio with 95% confidence intervals.

<p>Univariate and multivariate analyses of the risk of atrial fibrillation or flutter associated with each variable shown as hazard ratio with 95% confidence intervals.</p

Incidence rates of atrial fibrillation and flutter according to periodontitis status.

<p>Incidence rates of atrial fibrillation and flutter according to periodontitis status.</p

Colorimetric Detection of Lysozyme Based on Electrostatic Interaction with Human Serum Albumin-Modified Gold Nanoparticles

In this study, an aqueous solution of 13-nm gold nanoparticles (AuNPs) covalently bonded with human serum albumin (HSA) was used for sensing lysozyme (Lys). HSA molecules were good stabilizing agents for AuNPs in high-salt solution and exhibited the ability to bond with Lys electrostatically. The aggregation of HSA-AuNPs was achieved upon the addition of high-pI proteins, such as Lys, α-chymotrypsinogen A, and conalbumin. Not the same was achieved, however, when low-pI proteins such as ovalbumin, bovine serum albumin, and α-lactalbumin were added. Matrix-assisted desorption/ionization mass spectrometry was used to demonstrate the interaction between HSA-AuNPs and Lys. It was found that the sensitivity of HSA-AuNPs for Lys was highly dependent on the HSA concentration. The Lys-induced aggregation of HSA-AuNPs was suggested based on the London−van der Waals attractive force. We further improved the selectivity of the probe by adjusting the pH solution to 8.0. Under the optimum conditions, the selectivity of this system for Lys over other proteins in high-salt solutions was remarkably high, even when their pI was very close to the Lys. The lowest detectable concentration of Lys in this approach was 50 nM. The applicability of the method was validated through the analyses of Lys in chicken egg white

Risk of atrial fibrillation or flutter associated with periodontitis in the subgroups as stratified by other covariates.

<p>Adjusted variables included age, gender, average annual number of outpatient visits, and dental scaling frequency during the observation period and comorbidities.</p

Additional file 1 of Impact of systemic lupus erythematosus on the 5-year survival of critically ill septic patients

Additional file 1: Supplemental table 1. Patients with sepsis categorised by presence of SLE, admission to ICU, and requirment of mechanical ventilator. Supplemental table 2. Crude and adjusted hazard ratios for the association between variable and the risk for 5-year mortality among 2,565 enrolled subjects including SLE and matched non-SLE control subjects. Supplemental table 3. Crude and adjusted hazard ratios for the association between variable and the risk for 6-month mortality among 2,565 enrolled subjects including SLE and matched non-SLE control subjects. Supplemental table 4 . Crude and adjusted hazard ratios for the association between variable and the risk for 1-year mortality among 2,565 enrolled subjects including SLE and matched non-SLE control subjects. Supplemental table 5. Demographic data and clinical characteristics among 513 critically ill lupus patients categorised by the use of hydroxychloroquine. Supplemental table 6. Mortality in the 513 critically ill lupus patients who survived from sepsis with and without the use of hydroxychloroquine. Supplemental table 7. Crude and adjusted hazard ratios for the association between variable and the risk for 5-year mortality among 513 critically ill lupus patients who survived from sepsis

Transalkylation via C–N Bond Cleavage of Amines Catalyzed by Super Organophotoreductant CBZ6

The super organoreductant CBZ6-catalyzed tandem transalkylation–cyclization using amines as traceless radical donors and stabilizer is reported. The later-stage breaking of an N–C bond enables the transalkylation with a secondary amine as the leaving moiety. A wide range of tertiary amines were used as alkyl radical donors for the C1–C8 alkyls. This traceless stabilizer also enabled the transalkylation with methyl radical, which is normally not possible because of the instability of methyl radical