26 research outputs found
Divergent Synthesis of Benzene Derivatives: Brønsted Acid Catalyzed and Iodine-Promoted Tandem Cyclization of 5,2-Enyn-1-ones
Highly substituted benzene derivatives, including alkoxy-,
iodoalkoxy-,
and diiodo-substituted benzenes, can be selectively synthesized via
Brønsted acid catalyzed and iodine-promoted tandem carbocyclization
respectively. This reaction involved a direct process for C–C
bond formation from 5,2-enyn-1-ones, and different reaction systems
(Brønsted acids/electrophiles with solvents) afforded different
substituted benzenes. Furthermore, the halogenated moiety and alkoxy
group can be readily introduced into the benzene in a position which
has not been easily obtained previously
Gold-Catalyzed Tandem [3,3]-Propargyl Ester Rearrangement Leading to (<i>E</i>)‑1<i>H</i>‑Inden-1-ones
An efficient method for the synthesis
of (<i>E</i>)-1<i>H</i>-inden-1-ones using gold-catalyzed
tandem [3,3]-propargyl
ester rearrangement followed by Michael addition under mild reaction
conditions has been developed. The resulting products are important
frameworks found in numerous natural products and pharmaceutically
active compounds, as well as being valuable intermediates in organic
synthesis
Gold-Catalyzed Tandem [3,3]-Propargyl Ester Rearrangement Leading to (<i>E</i>)‑1<i>H</i>‑Inden-1-ones
An efficient method for the synthesis
of (<i>E</i>)-1<i>H</i>-inden-1-ones using gold-catalyzed
tandem [3,3]-propargyl
ester rearrangement followed by Michael addition under mild reaction
conditions has been developed. The resulting products are important
frameworks found in numerous natural products and pharmaceutically
active compounds, as well as being valuable intermediates in organic
synthesis
Gold-Catalyzed Tandem [3,3]-Propargyl Ester Rearrangement Leading to (<i>E</i>)‑1<i>H</i>‑Inden-1-ones
An efficient method for the synthesis
of (<i>E</i>)-1<i>H</i>-inden-1-ones using gold-catalyzed
tandem [3,3]-propargyl
ester rearrangement followed by Michael addition under mild reaction
conditions has been developed. The resulting products are important
frameworks found in numerous natural products and pharmaceutically
active compounds, as well as being valuable intermediates in organic
synthesis
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
TMSCl-Mediated Synthesis of α,β-Unsaturated Amides via C–C Bond Cleavage and C–N Bond Formation of Propargyl Alcohols with Trimethylsilyl Azide
A new
method with high efficiency for the synthesis of α,β-unsaturated
amides from the easily prepared propargyl alcohols and TMSN<sub>3</sub> using TMSCl as an acid promoter is developed. A wide variety of
α,β-unsaturated amides were produced in moderate to excellent
yields. Mechanistic studies indicate that this transformation involves TMSCl-mediated
allenylazide intermediate formation, C–C bond cleavage, and
C–N bond formation. Significantly, this reaction shows good
functional group compatibility and high regioselectivity, with a relatively
short reaction time and inexpensive reagents
Copper-Catalyzed Three-Component CyanoÂtrifluoroÂmethylaÂtion/AzidoÂtrifluoroÂmethylaÂtion and CarboÂcycliÂzation of 1,6-Enynes
A novel three-component
strategy for the cyanoÂtrifluoroÂmethylaÂtion/azidoÂtrifluoroÂmethylaÂtion
and carbocyclization of 1,6-enynes is developed. The reaction proceeds
smoothly under a moderate temperature by using a copper catalyst,
which provides a rapid and concise access to addition–carbocyclization
products. Furthermore, the products obtained can be useful building
blocks in discoveries of lead compounds and other biologically active
CF<sub>3</sub>-containing heterocycles