Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine

Described is a method for the transformation of a cyclic vinylogous ester to the corresponding polyarylated product. We found a catalytic system comprising palladium diacetate and tris­(1-adamantyl)­phosphine is quite effective in promoting a set of controlled cascade arylations. As a result, a range of novel (hetero)­aryl-containing scaffolds was synthesized with a high level of efficiency

Additional file 1 of The effect of antifibrotic agents on acute respiratory failure in COVID-19 patients: a retrospective cohort study from TriNetX US collaborative networks

Supplementary Material

Additional file 1 of TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

Additional file 1: Figure S1. Respiratory chain complex II SHDA is involved in TSLP-induced mitophagy. A The knockdown efficiency of SHDA was determined by western blot. B Mitophagy detection dye to quantify THP-1 cell mitophagy showed significantly increased fluorescence upon treatment with 40 ng/mL TSLP in the nontargeting control. When SHDA was knocked down, the increased fluorescence intensity of TSLP-induced mitophagy was inhibited. *p < 0.05, **p < 0.01 and ***p < 0.001 between THP-1 cells with and without TSLP treatment

Additional file 2 of TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

Additional file 2: Figure S2. The effects of TSLP on hypoxia-inducible factor (HIF)-1-BCL2-interacting protein 3 (BINP3) signaling

Additional file 1 of Effects of health-promoting school strategy on dental plaque control and preventive behaviors in schoolchildren in high-caries, rural areas of Taiwan: a quasi-experimental design

Additional file 1. Items of knowledge, attitude, self-efficacy and behavio

Additional file 2 of Effects of health-promoting school strategy on dental plaque control and preventive behaviors in schoolchildren in high-caries, rural areas of Taiwan: a quasi-experimental design

Additional file 2. Intervention strategies based on health-promoting school mode

Individual Species-Area Relationship of Woody Plant Communities in a Heterogeneous Subtropical Monsoon Rainforest

<div><p>The spatial structure of species richness is often characterized by the species-area relationship (SAR). However, the SAR approach rarely considers the spatial variability of individual plants that arises from species interactions and species’ habitat associations. Here, we explored how the interactions of individual plants of target species influence SAR patterns at a range of neighborhood distances. We analyzed the data of 113,988 woody plants of 110 species from the Fushan Forest Dynamics Plot (25 ha), northern Taiwan, which is a subtropical rainforest heavily influenced by typhoons. We classified 34 dominant species into 3 species types (i.e., accumulator, repeller, or no effect) by testing how the individual species-area relationship (i.e., statistics describing how neighborhood species richness changes around individuals) of target species departs (i.e., positively, negatively, or with no obvious trend) from a null model that accounts for habitat association. Deviation from the null model suggests that the net effect of species’ interactions increases (accumulate) or decreases (repel) neighborhood species richness. We found that (i) accumulators were dominant at small interaction distances (<10–30 m); (ii) the detection of accumulator species was lower at large interaction distances (>30 m); (iii) repellers were rarely detected; and (iv) large-sized and abundant species tended to be accumulators. The findings suggest that positive species interactions have the potential to accumulate neighborhood species richness, particularly through size- and density-dependent mechanisms. We hypothesized that the frequently disturbed environment of this subtropical rainforest (e.g., typhoon-driven natural disturbances such as landslides, soil erosion, flooding, and windthrow) might create the spatial heterogeneity of species richness and promote positive species interactions.</p></div

Species abundance rank distributions in relation to species types for various neighborhood distance classes.

<p>(A) Homogeneous and (B) heterogeneous Poisson null models. Solid circles, open circles, and open triangles represent positive, negative, and no deviation from conventional SAR in (A) and indicate accumulator, repeller, and no effect types in (B), respectively. Panels are arranged in order of increasing neighborhood distance from top to bottom: 1–10 m, 11–20 m, 21–30 m, 31–40 m, and 41–50 m.</p

Proportion of species types along neighborhood distances.

<p>(A) Homogeneous and (B) heterogeneous Poisson null models for “large-large relationships” and (C) heterogeneous Poisson null model for “large-small relationships.” The broken, dotted, and solid lines indicate the positive, negative, and no deviation from conventional SAR in (A) and the accumulator, repeller, and no effect types in (B, C), respectively.</p

Data_Sheet_1_Relationship Between Weight Status and Self-Image Mediated by Pubertal Timing and Athletic Competence: A Cohort Study With Taiwanese Adolescents.pdf

BackgroundSelf-image reflects overall self-acceptance in developing adolescents. Using a representative cohort of Taiwanese youth, this study aims to explore the relationship between weight status, pubertal timing, athletic competence, and adolescent self-image.MethodsData come from the Taiwan Youth Project that comprised a longitudinal cohort of adolescents (N = 2690, 51% males, Mage = 13.3 ± 0.5 years) surveyed annually from seventh grade. Self-image was measured by perceived satisfaction with appearance and physique. Weight status was proxied by self-reported body mass index (BMI; kg/m2). Pubertal timing was defined using the Pubertal Developmental Scale, which mainly measured physical changes in puberty. Athletic competence was assessed by experiences with participation in competitive sports and self-perceived talent for sports. Linear regression analysis was applied to test for an association between BMI and self-image. In order to test for mediating roles of pubertal timing and athletic competence, Hayes' PROCESS macro on SPSS was conducted applying 5,000 bootstrap resamples with 95% confidence intervals of the indirect effect.ResultsBMI was inversely associated with self-image in both males (β = −0.074, [−0.095, −0.053]) and females (β = −0.095, [−0.122, −0.069]). The boot-strapped 95% confidence intervals indicated statistically significant mediating effects of pubertal timing (β = −0.008, [−0.015, −0.001]) and athletic competence (β = −0.006, [−0.011, −0.002]) in the link between BMI and self–image in females, whilst only athletic competence mediated this association (β = −0.006, [−0.009, −0.002]) in males. Moreover, BMI at baseline were also associated with long-term self-image in males (β = −0.037, [−0.057, −0.017]) and females (β = 0.132, [0.073, 0.190]).ConclusionsUnderstanding the mediating factors may help enhance adolescents' self-image by providing guidance on healthy weight and physical activity behaviors according to different stages of pubertal progression.</p