Nyelv, nyelvtörvény, nyelvtudomány

<p>4a, Forest plot on the associations between DM and bile leakage after hepatectomy. 4b, Forest plot on the associations between DM and ascites after hepatectomy. 4c, Forest plot on the associations between DM and liver decompensation after hepatectomy. DM, diabetes mellitus. The boxes and lines indicate the relative ratios (RRs) and their confidence intervals (CIs) on a log scale for each study. The pooled RR is represented by a diamond. The size of the black squares indicates the relative weight of each estimate.</p

Data for: Towards high-efficient industrial p-type mono-like Si PERC solar cells

all the data based on the origin.ex

Chemical constituents from <i>Oldenlandia diffusa</i> and their cytotoxic effects on human cancer cell lines

Oldenlandia diffusa is an important Chinese traditional medicine with various biological activities such as anti-tumor, anti-inflammatory, anti-oxidant, antibacterial, neuroprotective and hepatoprotective effects. During our course of finding novel compounds from O. diffusa, two new alternariol derivatives named 9-O-(trans-p-coumaroyl)-alternariol (1), 9-O-(trans-caffeoyl)-alternariol (2), together with six known compounds (3-8) were isolated. Their structures were established on the basis of spectroscopic and physicochemical analysis. All isolates were evaluated for in vitro cytotoxic activities on MCF-7, HepG2, A549 and A2780 cancer cells. As a result, new compounds 1 and 2 exhibited potent cytotoxic activities on A2780 cancer cells with IC50 values of 3.1 and 9.4 μM, respectively. And a conclusion was deduced that the p-coumaroyl or caffeoyl moiety could greatly increased the cytotoxic activity of alternariol on cancer cells.</p

Engineering Ratiometric Persistent Luminous Sensor Arrays for Biothiols Identification

Thiols play vital roles in mediating physiological processes. However, it is difficult to discriminate one thiol from another because of the similarities among structures and reactivities of thiols. In light of the ultralow background and impressive discrimination power, a persistent luminescence-based sensing array has attracted increasing attention but still remains a huge challenge. Herein, we have thoroughly studied the chemistry involving dual-emission persistent luminescence nanoparticles (D-PLNPs) with metal ions (MIs) and for the first time proposed an MIs-triggered ratiometric persistent luminescence (R-PersL) sensor array for the discrimination of six thiols. To extract data-rich outputs from a single sensor element, three representative D-PLNPs with a core–shell structure and subsequent carboxyl functionalizations (CSD-PLNPs) were rationally fabricated. Interestingly, MIs revealed the different regulating efficiencies for the two main emission bands of CSD-PLNPs, resulting from MI-triggered R-PersL signal transductions. Inspired by the crucial roles of thiols in vivo, a proof-of-concept sensor array through the ensemble of CSD-PLNPs-COOH and certain MIs was developed and demonstrated aR-PersL “fingerprint“ pattern identification for six thiols. Remarkably, because of the autofluorescence-free background and high-throughput signal output, this sensing array system enabled a highly sensitive and differentiable detection of thiols at various concentrations in human blood serums, paving a new way to develop multiparameters sensing for complex analytes

Evaluating the Band Gaps of Semiconductors by Cataluminescence

A rapid and efficient methodology for the evaluation of band gaps of semiconductors is highly desirable to analyze and assess the intrinsic properties and extending application scopes of semiconductor materials. Here, the negative correlation of the cataluminescence (CTL) signal in the presence of H2S and the band gap of Aurivillius-type perovskite oxide Bi4+nFenTi3O12+3n (n = 1–4) was confirmed, where the H2S-induced CTL signal acts as a probe to evaluate the band gaps of semiconductor materials. The related mechanism shows that the thermal energy obtained by heating makes the electrons in the valence band more easily excite into the conduction band of a narrower band gap material and further promotes electron transfer between the gaseous compounds and semiconductor materials, causing acceleration of the catalytic oxide process. In addition, the extensibility was further verified by exploring the layered perovskite containing other insertion structures, including Bi4+nConTi3O12+3n (n = 1–4), Bi5NiTi3O15, and Bi5MnTi3O15, which was also consistent with the results characterized by UV diffuse reflectance spectroscopy. The established CTL probe for band gap evaluation shows rapid response, is simple to operate, and is of low cost, which is expected to become an innovative alternative to the conventional band gap assessment approach

Turn-on Persistent Luminescence Probe Based on Graphitic Carbon Nitride for Imaging Detection of Biothiols in Biological Fluids

Herein, we present a novel strategy based on a “turn-on” persistent luminescence imaging chemical system of graphitic carbon nitride for detecting biothiols in biological fluids. Graphitic carbon nitride (g-C₃N₄) as persistent luminescence probe is fabricated via a new procedure based on pyrolysis of guanidine hydrochloride under ambient atmospheric conditions. The prepared g-C₃N₄ nanosheets give intensively long-persistent luminescence that can avoid interference from biological media such as tissue autofluorescence and scattering light. The original persistent luminescence of g-C₃N₄ turns off due to the adsorption of silver ion (Ag⁺) onto g-C₃N₄ materials with an electron transfer process. The presence of biothiols induces the onset of persistent luminescence emission by interrupting the quenching interaction, thereby turning on the imaging probe. The approach exhibits high specificity and high sensitivity to biothiols with low detection limit for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) with 6.4, 8.1, and 9.6 nM, respectively. It is also successfully applied for imaging detection of biothiols in human urine, plasma, and cell lysates, demonstrating its great value of practical application in biological systems

Carbon Nitride Quantum Dots: A Novel Chemiluminescence System for Selective Detection of Free Chlorine in Water

A facile one-step microwave-assisted approach for the preparation of strong fluorescent carbon nitride quantum dots (g-CNQDs) by using guanidine hydrochloride and EDTA as the precursors was developed. Strong chemiluminescence (CL) emission was observed when NaClO was injected into the prepared g-CNQDs, and a novel CL system for direct detection of free chlorine was established. Free residual chlorine in water was sensitively detected with a detection limit of 0.01 μM and had a very wide detection range of 0.02 to 10 μM. On the basis of CL spectral, UV–visible absorption spectral, and electron spin resonance (ESR) spectral studies, as well as investigations on the effects of various free radical scavengers, a possible CL mechanism was proposed. It was suggested that the radiative recombination of oxidant-injected holes and electrons in the g-CNQDs accounted for the CL emission. Meanwhile, 1O2 on the surface of g-CNQDs, generated from some reactive oxygen species in the g-CNQDs-NaClO system, could transfer energy to g-CNQDs and thus further enhance the CL emission. The CL system is highly sensitive and differentiable, opening a new field for the development of novel CL-emitting species, but also expanding the conventional optical utilizations of g-CNQDs

Multiplex DNA Walking Machines for Lung Cancer-Associated miRNAs

Biomimetic DNA walking machines have gained great success in scrutinizing the microscopic world and sensitive biosensing of disease biomarkers. Despite superb achievements, the research on DNA walking machines for simultaneous detection of multiple analytes is still rare, while the design and realization of multiplexing are considered as an important bottleneck. The multiplex detection of biomarkers can not only improve the specificity of bioassays but also avoid the squander of valuable biological specimens. Herein, we reported multiplex three-dimensional (3D) DNA walking machines based on high-resolution inductively coupled plasma mass spectrometry (HR-ICPMS) for lung cancer-associated miRNA detection. In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS. The recovery test of target miRNAs in human serum and the simultaneous monitoring experiment of three miRNAs in human lung cancer cell line (A549) and normal cell line (HBE) specimens display satisfactory analysis capabilities for complex biological samples. Thanks to the vast potential of lanthanide tags and the modular design, the proposed bioassay might flexibly detect different miRNA combinations with corresponding sets of DNA walking machines to meet the requirements of various tasks

Lanthanide Nanoprobes for the Multiplex Evaluation of Breast Cancer Biomarkers

Metal stable isotope tagging has demonstrated great and unique success in the multiplex and ratiometry-based accurate detection of biomolecules and single cells, while its sensitivity is regarded as an Achilles’ heel. Although lanthanide nanoparticles remain the most promising tags for elemental mass spectrometry, there is no report on the lanthanide nanoparticle-based multiplex immunoassay of disease markers in clinical serum samples because of their tough synthesis and bioconjugation and a complex physiological sample matrix. Herein, to fill this gap, multiple lanthanide nanoparticle tags (NaEuF4, NaTbF4, and NaHoF4) were delicately designed and facilely synthesized with a one-pot solvothermal method for the multiplex evaluation of breast cancer biomarkers carcinoembryonic antigen (CEA), CA153, and CA125 in human serum samples. The proposed method exhibited wide linear ranges and low levels of the detection limit for all biomarkers. The test results were consistent with the routine electrochemiluminescence results in clinical serum samples, which proved the possibility of the early prognosis of breast cancer as well as improving the surgical outcome prediction