MOESM2 of A technical appraisal of guidelines for the management of skin rash in patients on chemotherapy and targeted therapy

Additional file 2. Internet list

MOESM1 of A technical appraisal of guidelines for the management of skin rash in patients on chemotherapy and targeted therapy

Additional file 1. Search method

Biomimetic Ag/ZnO@PDMS Hybrid Nanorod Array-Mediated Photo-induced Enhanced Raman Spectroscopy Sensor for Quantitative and Visualized Analysis of Microplastics

Microplastics are persistent pollutants that accumulate in the environment and can cause serious toxicity to mammals. At present, few technologies are able to quantitatively detect chemicals and provide morphological information simultaneously. Herein, we developed a dragonfly-wing-mimicking ZnO nanorod array decorated with AgNPs on polydimethylsiloxane (PDMS) as a surface-enhanced Raman spectroscopy (SERS) and photo-induced enhanced Raman spectroscopy (PIERS) substrate for trace analysis of microplastics. The Ag/ZnO@PDMS hybrid nanorod array endows the sensor with high sensitivity and signal repeatability (RSD ∼ 5.89%), ensuring the reliable quantitative analysis of microplastics. Importantly, when the noble metal–semiconductor substrate was pre-radiated with ultraviolet light, a surprising PIERS was attained, achieving an additional enhancement of 11.3-fold higher than the normal SERS signal. By combining the PIERS technology with the “coffee ring effect”, the sensor successfully discerned microplastics of polyethylene (PE) and polystyrene (PS) at a trace level of 25 μg/mL even with a portable Raman device. It was capable of identifying PS microspheres in contaminated tap water, lake water, river water, and seawater with detection limits of 25, 28, 35, and 60 μg/mL, respectively. The recovery rates of PS microspheres in four water environments ranged from 94.8 to 102.4%, with the RSD ranging from 2.40 to 6.81%. Moreover, quantitative and visualized detection of microplastics was readily realized by our sensor. This portable PIERS sensor represents a significant step toward the generalizability and practicality of quantitative and visual sensing technology

Additional file 1 of Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy

Additional file 1: Figure S1. Large scale demethylation is initiated by DAC. Figure S2. Dynamic expression changes of important immune related genes. Figure S3. Tsne analysis of T cells in peripheral blood and spleen after Runx3 conditional knockout in CD8+T cell. Figure S4. Tsne analysis of T cells in peripheral blood and spleen after PD-1 and DAC+PD-1 treatment in Runx3flfl mice. Figure S5. CD8+ level did not changed when treated with PD-1 or DAC/PD-1. Table 1. Patient charcateristics. Table 2. Primer sequences for mRNA quantification. Table 3. Antibodies for flow cytometry. Table 4. Antibodies for Mass cytometry