Estimate of the MR analysis for the white blood cells and HbA1c.

Estimate of the MR analysis for the white blood cells and HbA1c.</p

Estimate of the MR analysis for the white blood cells and FG.

Estimate of the MR analysis for the white blood cells and FG.</p

MR analyses testing the effects of five WBC subtypes on T2D.

The result of univariable MR obtained using four MR approaches (IVW, MR-Egger, Weighted-median, and weighted mode) and multivariable MR obtained using two MR approaches (IVW and MR-Egger) of Model 3. Causal estimates were presented as a heatmap. All results indicated no statistically significance.</p

Estimate of the univariable MR analysis for the white blood cells and risk of T2D.

Estimate of the univariable MR analysis for the white blood cells and risk of T2D.</p

Heterogeneity and pleiotropy test of the causal effect of white blood cells on FPG, HbA1c, and HOMA-IR.

Heterogeneity and pleiotropy test of the causal effect of white blood cells on FPG, HbA1c, and HOMA-IR.</p

Results of heterogeneity and pleiotropy tests of the causal effect of WBC on T2D.

Results of heterogeneity and pleiotropy tests of the causal effect of WBC on T2D.</p

MR analyses testing the effect of five WBC subtypes on glycemic traits.

Results obtained using 4 MR approaches (IVW, MR-Egger, Weighted-median and weighted-mode) were presented as a heatmap representing causal estimate. All results indicated no statistically significance.</p

Forest plot, scatter plot, funnel plot, and leave-one-out analysis of univariable MR analysis for the causal effect of WBC subtypes on T2D.

Forest plot, scatter plot, funnel plot, and leave-one-out analysis of univariable MR analysis for the causal effect of WBC subtypes on T2D.</p

Reverse MR analysis of the causal effect of T2D on white blood cells.

Reverse MR analysis of the causal effect of T2D on white blood cells.</p

Detailed information on the IVs used in the MR analyses for the causal effect of T2D on WBC subtypes.

Detailed information on the IVs used in the MR analyses for the causal effect of T2D on WBC subtypes.</p