Construction of Ru–N Single Sites for Effective Acetylene Hydrochlorination: Effect of Polyethyleneimine Modifiers

Several single-site catalysts have been synthesized through the chelation of polyethyleneimine (PEI) with Ru precursors because of the lack of durable active sites in Ru catalysts for acetylene hydrochlorination. Proper thermal activation successfully constructed the local active domains of Ru–N. Ru species were stabilized in their active states by coordinating N in PEI with the central atom Ru in the Ru/activated carbon (AC) catalyst. The metal and highly electronegative heteroatomic sites in the Ru–N domains augmented the activation ability of reactant molecules synergistically. The synthetic strategy developed led to the dispersion of active metal at the level of a single site. Additionally, more Ru–N–C interfaces formed after appropriate pyrolysis of the catalyst (Ru/AC@PEI-T), increasing the contact area to reactants and improving the catalytic efficiency. The modified Ru/AC@PEI catalyst has significantly enhanced catalytic stability over time, allowing for possible industrial applications

DataSheet_1_[18F]AlF-NOTA-ADH-1: A new PET molecular radiotracer for imaging of N-cadherin-positive tumors.docx

BackgroundThe cell adhesion molecule (CAM) N-cadherin has become an important target for tumor therapy. The N-cadherin antagonist, ADH-1, exerts significant antitumor activity against N-cadherin-expressing cancers.MethodsIn this study, [18F]AlF-NOTA-ADH-1 was radiosynthesized. An in vitro cell binding test was performed, and the biodistribution and micro-PET imaging of the probe targeting N-cadherin were also studied in vivo.ResultsRadiolabeling of ADH-1 with [18F]AlF achieved a yield of up to 30% (not decay-corrected) with a radiochemical purity of >97%. The cell uptake study showed that Cy3-ADH-1 binds to SW480 cells but weakly binds to BXPC3 cells in the same concentration range. The biodistribution results demonstrated that [18F]AlF-NOTA-ADH-1 had a good tumor/muscle ratio (8.70±2.68) in patient-derived xenograft (PDX) tumor xenografts but a lower tumor/muscle ratio (1.91±0.69) in SW480 tumor xenografts and lowest tumor/muscle ratio (0.96±0.32) in BXPC3 tumor xenografts at 1 h post-injection (p.i.) These findings were in accordance with the immunohistochemistry results. The micro PET imaging results revealed good [18F]AlF-NOTA-ADH-1 tumor uptake in pancreatic cancer PDX xenografts with strong positive N-calcium expression, while lower tumor uptake in SW480 xenografts with positive expression of N-cadherin, and significantly lower tumor uptake in BXPC3 xenografts with low expression of N-cadherin, which was consistent with the biodistribution and immunohistochemistry results. The N-cadherin-specific binding of [18F]AlF-NOTA-ADH-1 was further verified by a blocking experiment involving coinjection of a non radiolabeled ADH-1 peptide, resulting in a significant reduction in tumor uptake in PDX xenografts and SW480 tumor.Conclusion[18F]AlF-NOTA-ADH-1 was successfully radiosynthesized, and Cy3-ADH-1 showed favorable N-cadherin-specific targeting ability by in vitro data. The biodistribution and microPET imaging of the probe further showed that [18F]AlF-NOTA-ADH-1 could discern different expressions of N-cadherin in tumors. Collectively, the findings demonstrated the potential of [18F]AlF-NOTA-ADH-1 as a PET imaging probe for non-invasive evaluation of the N-cadherin expression in tumors.</p

Video_1_Case report: Ultrasound-guided needle knife technique for carpal ligament release in carpal tunnel syndrome treatment.MP4

Carpal tunnel syndrome (CTS) is a common peripheral neuropathy of the hand, mainly manifesting as sensory disturbances, motor dysfunctions, and pain in the fingers and hand. The pathogenesis of the disease is associated with fibrosis of the transverse carpal ligament in the carpal tunnel, which compresses median nerve. In our case, we demonstrate an ultrasound-guided needle knife technique to treat CTS. We guided the patient to a supine position on the examination table. The skin of the wrist area was sterilized for the procedure. After the skin was dry, we positioned sterile drapes, located the median nerve and compression, and marked the compression point. Local anesthesia was administered. An ultrasound-guided needle knife was inserted. The needle knife was advanced under ultrasound guidance. The carpal ligament was incised. A gradual release of pressure on the median nerve was observed on the ultrasound monitor. After treatment, the patient’s finger sensation and motor function can significantly improve, and pain symptoms are markedly reduced, this case demonstrates that small needle-knife treatment can serve as a safe and effective minimally invasive therapeutic method.</p

Image_2_Clinical characteristics and management experience of schwannoma in extremities: Lessons learned from a 10-year retrospective study.TIF

IntroductionSchwannomas are the most common neoplastic lesions of the peripheral nerves when growing on the extremities, they usually have adverse effects on patients due to the exposed and functional nature of the region.MethodsIn the present single-center retrospective study, we included all patients with pathologically confirmed schwannoma located in extremities between 2011 and 2021 totaling 183 patients. Data on gender, age, duration history, clinical presentation, occurrence region, nerve affiliation, imaging data, modus operation, mass volume, immunohistochemistry, postoperative neurological function, and recurrence were collected.ResultsAs in previous studies, patients were predominantly middle-aged with a mean age of 49.5, without gender preference and a male-to-female ratio of 1.2:1. Most patients are first seen for this disease, and only five of them are recurrent. The majority presented with an isolated (91.26%), asymptomatic (37.7%) mass, with tenderness (34.97%) being the second frequent complaint. 60% of lesions occurred in the upper extremity, more commonly on the left side (55.26%) than the right. The average duration of onset was 47.50 months. MRI is more sensitive for neurogenic tumors than ultrasound, as it owns 78.93% correct. In immunohistochemistry, the top three markers for positive labeling schwannoma are S-100 (98.95%), Ki67 (98.68%) and β-Catenin. 98.36% of patients underwent complete resection of the lesion, of which 14.44% required partial sacrifice of the nerve fibers. Thanks to the application of intraoperative peripheral nerve microscopic operation, only 6 patients showed symptoms of postoperative nerve injury, and 3 of them received second surgery. Intraoperative microscopic manipulation, preservation of the main nerve, and the need for reconstruction of the affected nerve fibers are some of the points worth noting.DiscussionIn summary, the possibility of schwannoma should not be overlooked in the identification of masses that occur in the upper extremities of the middle-aged population. Preoperative ultrasound and MR are useful for determining the nature of the mass, and S100, Ki67, and β-Catenin are sensitive to it. Surgical resection can achieve satisfying functional results and a low risk of nerve injury.</p

Construction of Highly Dispersed Cu–P/Cl Active Sites Using Methyldiphenyloxophosphine for Efficient Acetylene Hydrochlorination

To overcome the disadvantages of Cu-based catalysts, such as the low dispersion of active components and insufficient active species, several 15% Cu-Lx/AC catalysts for acetylene hydrochlorination were synthesized based on strong interactions between a ligand and CuCl2 precursors. The introduction of the methyldiphenyloxophosphine (MDPO) ligand effectively modulated the electronic properties of the metal centers, which contributed to the construction of a highly dispersed Cu–P/Cl local structure with Cu1+/Cu2+ as a plausible active center. The sintering of active components in the catalyst may be one of the main reasons for the decrease in catalytic performance. Meanwhile, the enhanced adsorption and activation of the catalyst for C2H2 and HCl molecules resulted in improved coking resistance. The most active catalyst (15% Cu8MDPO1/AC) could achieve a stable acetylene conversion of 97% at 180 °C, a gas hourly space velocity (GHSV) (C2H2) of 180 h–1, and a feed volume ratio (VHCl/VC2H2) of 1.15, outperforming the benchmark catalyst. The excellent activity and stability in a 300 h laboratory test at a high GHSV and a 3414 h industrial sideline test at an industrial GHSV render the 15% Cu8MDPO1/AC catalyst as a reference for the construction of other catalysts from an environmental, economic, and application prospect perspective

Image_1_Clinical characteristics and management experience of schwannoma in extremities: Lessons learned from a 10-year retrospective study.TIF

IntroductionSchwannomas are the most common neoplastic lesions of the peripheral nerves when growing on the extremities, they usually have adverse effects on patients due to the exposed and functional nature of the region.MethodsIn the present single-center retrospective study, we included all patients with pathologically confirmed schwannoma located in extremities between 2011 and 2021 totaling 183 patients. Data on gender, age, duration history, clinical presentation, occurrence region, nerve affiliation, imaging data, modus operation, mass volume, immunohistochemistry, postoperative neurological function, and recurrence were collected.ResultsAs in previous studies, patients were predominantly middle-aged with a mean age of 49.5, without gender preference and a male-to-female ratio of 1.2:1. Most patients are first seen for this disease, and only five of them are recurrent. The majority presented with an isolated (91.26%), asymptomatic (37.7%) mass, with tenderness (34.97%) being the second frequent complaint. 60% of lesions occurred in the upper extremity, more commonly on the left side (55.26%) than the right. The average duration of onset was 47.50 months. MRI is more sensitive for neurogenic tumors than ultrasound, as it owns 78.93% correct. In immunohistochemistry, the top three markers for positive labeling schwannoma are S-100 (98.95%), Ki67 (98.68%) and β-Catenin. 98.36% of patients underwent complete resection of the lesion, of which 14.44% required partial sacrifice of the nerve fibers. Thanks to the application of intraoperative peripheral nerve microscopic operation, only 6 patients showed symptoms of postoperative nerve injury, and 3 of them received second surgery. Intraoperative microscopic manipulation, preservation of the main nerve, and the need for reconstruction of the affected nerve fibers are some of the points worth noting.DiscussionIn summary, the possibility of schwannoma should not be overlooked in the identification of masses that occur in the upper extremities of the middle-aged population. Preoperative ultrasound and MR are useful for determining the nature of the mass, and S100, Ki67, and β-Catenin are sensitive to it. Surgical resection can achieve satisfying functional results and a low risk of nerve injury.</p

sj-pdf-1-ajs-10.1177_03635465231208843 – Supplemental material for Fibroblast Activation Protein–Targeted PET/CT with Al18F-NODA-FAPI-04 for In Vivo Imaging of Tendon Healing in Rat Achilles Tendon Injury Models

Supplemental material, sj-pdf-1-ajs-10.1177_03635465231208843 for Fibroblast Activation Protein–Targeted PET/CT with Al18F-NODA-FAPI-04 for In Vivo Imaging of Tendon Healing in Rat Achilles Tendon Injury Models by Zhenfeng Liu, Haiying Zhou, Pengfei Li, Zewei Wang, Tian Tu, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Ahmad Alhaskawi, Yanzhao Dong, Yuqiao Huang, Mengjie Dong, Xinhui Su and Hui Lu in The American Journal of Sports Medicine</p