3 research outputs found

    Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles

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    A simple combination of CuI/LiO<i>t</i>Bu/DMF enables the tandem Huisgen [3 + 2] cycloaddition/amidation reaction of terminal alkynes and sulfonyl azides to 5-sulfamide-1-(<i>N</i>-sulfonyl)-1,2,3-triazoles <b>I</b>, which can undergo an alkylation/desulfonation sequence to deliver highly substituted aminotriazoles <b>II</b> by one-pot or one-pot, two-step procedures

    Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles

    No full text
    A simple combination of CuI/LiO<i>t</i>Bu/DMF enables the tandem Huisgen [3 + 2] cycloaddition/amidation reaction of terminal alkynes and sulfonyl azides to 5-sulfamide-1-(<i>N</i>-sulfonyl)-1,2,3-triazoles <b>I</b>, which can undergo an alkylation/desulfonation sequence to deliver highly substituted aminotriazoles <b>II</b> by one-pot or one-pot, two-step procedures

    Coupling and Decoupling Approach Enables Palladium-Catalyzed Aerobic Bimolecular Carbocyclizations of Enediynes to 2,6-Diacylnaphthalenes

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    A formal palladium-catalyzed aerobic bimolecular carbocyclization reaction of (<i>Z</i>)-hexa-1,5-diyn-3-ene scaffolds has been successfully developed for the construction of 2,6-diacylnaphthalenes, wherein copper salts play a critical role in accomplishing the oxygenative homo- and hetero-dimerization processes of readily accessible enediyne–carboxylic acids and esters, respectively. The enediyne dimerization protocol provides a flexible and regiospecific approach to a variety of functionalized naphthalenes with up to six differentiated substituents in good yields by using a directing-group-assisted coupling and decoupling strategy. Mechanistic studies indicated that the two oxygen atoms being selectively incorporated into the crossover-annulation products of enediynecarboxylic acid and ester directly originate from atmospheric molecular oxygen and H<sub>2</sub>O, respectively
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