3 research outputs found
Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles
A simple
combination of CuI/LiO<i>t</i>Bu/DMF enables
the tandem Huisgen [3 + 2] cycloaddition/amidation reaction of terminal
alkynes and sulfonyl azides to 5-sulfamide-1-(<i>N</i>-sulfonyl)-1,2,3-triazoles <b>I</b>, which can undergo an alkylation/desulfonation sequence
to deliver highly substituted aminotriazoles <b>II</b> by one-pot
or one-pot, two-step procedures
Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles
A simple
combination of CuI/LiO<i>t</i>Bu/DMF enables
the tandem Huisgen [3 + 2] cycloaddition/amidation reaction of terminal
alkynes and sulfonyl azides to 5-sulfamide-1-(<i>N</i>-sulfonyl)-1,2,3-triazoles <b>I</b>, which can undergo an alkylation/desulfonation sequence
to deliver highly substituted aminotriazoles <b>II</b> by one-pot
or one-pot, two-step procedures
Coupling and Decoupling Approach Enables Palladium-Catalyzed Aerobic Bimolecular Carbocyclizations of Enediynes to 2,6-Diacylnaphthalenes
A formal
palladium-catalyzed aerobic bimolecular carbocyclization
reaction of (<i>Z</i>)-hexa-1,5-diyn-3-ene scaffolds has
been successfully developed for the construction of 2,6-diacylnaphthalenes,
wherein copper salts play a critical role in accomplishing the oxygenative
homo- and hetero-dimerization processes of readily accessible enediyne–carboxylic
acids and esters, respectively. The enediyne dimerization protocol
provides a flexible and regiospecific approach to a variety of functionalized
naphthalenes with up to six differentiated substituents in good yields
by using a directing-group-assisted coupling and decoupling strategy.
Mechanistic studies indicated that the two oxygen atoms being selectively
incorporated into the crossover-annulation products of enediynecarboxylic
acid and ester directly originate from atmospheric molecular oxygen
and H<sub>2</sub>O, respectively