Photocured Materials with Self-Healing Function through Ionic Interactions for Flexible Electronics

Photocured materials with self-healing function have the merit of long lifetime and environmentally benign preparation process and thus find potential applications in various fields. Herein, a novel imidazolium-containing photocurable monomer, (6-(3-(3­(2-hydroxyethyl)-1<i>H</i>-imidazol-3-ium bromide)­propanoyloxy)­hexyl acrylate, IM-A), was designed and synthesized. Self-healing polymers were prepared by fast photocuring with IM-A, isobornyl acrylate, 2-(2-ethoxyethoxy)­ethyl acrylate, and 2-hydroxyethyl acrylate as the monomers. The mechanical and self-healing properties of the polymers were tuned by varying the contents of IM-A and other monomers. The as-prepared self-healing polymer IB7-IM5 exhibited a tensile strength of 3.1 MPa, elongation at break of 205%, healing efficiency of 93%, and a wide healing temperature range from room temperature to 120 °C. The self-healing polymer was also employed as a flexible substrate to fabricate a flexible electronic device, which could be healed and completely restore its conductivity after the device was damaged

Photocured Materials with Self-Healing Function through Ionic Interactions for Flexible Electronics

Photocured materials with self-healing function have the merit of long lifetime and environmentally benign preparation process and thus find potential applications in various fields. Herein, a novel imidazolium-containing photocurable monomer, (6-(3-(3­(2-hydroxyethyl)-1<i>H</i>-imidazol-3-ium bromide)­propanoyloxy)­hexyl acrylate, IM-A), was designed and synthesized. Self-healing polymers were prepared by fast photocuring with IM-A, isobornyl acrylate, 2-(2-ethoxyethoxy)­ethyl acrylate, and 2-hydroxyethyl acrylate as the monomers. The mechanical and self-healing properties of the polymers were tuned by varying the contents of IM-A and other monomers. The as-prepared self-healing polymer IB7-IM5 exhibited a tensile strength of 3.1 MPa, elongation at break of 205%, healing efficiency of 93%, and a wide healing temperature range from room temperature to 120 °C. The self-healing polymer was also employed as a flexible substrate to fabricate a flexible electronic device, which could be healed and completely restore its conductivity after the device was damaged

Photocured Materials with Self-Healing Function through Ionic Interactions for Flexible Electronics

Photocured materials with self-healing function have the merit of long lifetime and environmentally benign preparation process and thus find potential applications in various fields. Herein, a novel imidazolium-containing photocurable monomer, (6-(3-(3­(2-hydroxyethyl)-1<i>H</i>-imidazol-3-ium bromide)­propanoyloxy)­hexyl acrylate, IM-A), was designed and synthesized. Self-healing polymers were prepared by fast photocuring with IM-A, isobornyl acrylate, 2-(2-ethoxyethoxy)­ethyl acrylate, and 2-hydroxyethyl acrylate as the monomers. The mechanical and self-healing properties of the polymers were tuned by varying the contents of IM-A and other monomers. The as-prepared self-healing polymer IB7-IM5 exhibited a tensile strength of 3.1 MPa, elongation at break of 205%, healing efficiency of 93%, and a wide healing temperature range from room temperature to 120 °C. The self-healing polymer was also employed as a flexible substrate to fabricate a flexible electronic device, which could be healed and completely restore its conductivity after the device was damaged

Synthetic Strategy and Performances of a UV-Curable Poly Acryloyl Phosphinate Flame Retardant by Carbene Polymerization

<div><p>GRAPHICAL ABSTRACT</p><p></p></div

Synthesis and Performances of UV-Curable Polysiloxane–Polyether Block Polyurethane Acrylates for PVC Leather Finishing Agents

A series of multifunctional UV-curable polysiloxane–polyether block polyurethane acrylates prepolymers (TSi¹E⁹PUA, TSi³E⁷PUA, TSi⁵E⁵PUA, TSi⁷E³PUA, and TSi⁹E¹PUA) used for polyvinyl chloride (PVC) leather finishing agents have been prepared and characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR), and gel permeation chromatography (GPC). All five multifunctional prepolymers exhibited excellent photopolymerization efficiency and good yellowing resistance. And the content of polysiloxane in prepolymers obviously affected the viscosity, thermal stability, tensile strength, elongation at break, and surface hydrophobicity of the photopolymerization systems. The system with the prepolymer containing more polysiloxane segments presented a high viscosity, and UV-cured film had relatively good thermal stability, elongation at break, and surface hydrophobicity accordingly. The properties of the prepolymers well satisfied the application requirements for leather finishing agents. Furthermore, surface microstructures of UV-cured films were characterized by scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS). More importantly, the PVC leather finishing agents designed based on the multifunctional polysiloxane–polyether block polyurethane acrylates possessed excellent comprehensive performances

Real-Time Imaging of Single-Molecule Enzyme Cascade Using a DNA Origami Raft

The dynamics of enzymes are directly associated with their functions in various biological processes. Nevertheless, the ability to image motions of single enzymes in a highly parallel fashion remains a challenge. Here, we develop a DNA origami raft-based platform for in-situ real-time imaging of enzyme cascade at the single-molecule level. The motions of enzymes are rationally controlled via different tethering modes on a two-dimensional (2D) supported lipid bilayer (SLB). We construct an enzyme cascade by anchoring catalase on cholesterol-labeled double-stranded (ds) DNA and glucose oxidase on cholesterol-labeled origami rafts. DNA functionalized with cholesterol can be readily incorporated in SLB via the cholesterol–lipid interaction. By using a total internal reflection fluorescence microscope (TIRFM), we record the moving trajectory of fluorophore-labeled single enzymes on the 2D surface: the downstream catalase diffuses freely in SLB, whereas the upstream glucose oxidase is relatively immobile. By analyzing the trajectories of individual enzymes, we find that the lateral motion of enzymes increases in a substrate concentration-dependent manner and that the enhanced diffusion of enzymes can be transmitted via the cascade reaction. We expect that this platform sheds new light on studying dynamic interactions of proteins and even cellular interactions

Data_Sheet_1_Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.pdf

IntroductionAge is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.Methods: In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent memory impairment and explore the potential mechanisms. Here, D-galactose was used to produce a conventional aging model resulting in memory dysfunction.ResultsCirc-Vps41 was significantly downregulated in D-galactose-induced aging in vitro and in vivo. The overexpression of circ-Vps41 could upregulate synaptophysin (Syp), thereby promoting the synaptic plasticity and alleviating cognitive impairment in aging mice. Mechanistically, we found that circ-Vps41 upregulated Syp expression by physically binding to miR-24-3p. Moreover, the miR-24-3p mimics reversed the circ-Vps41 overexpression-induced increase in Syp expression.DiscussionOverexpression of circ-Vps41 alleviated the synaptic plasticity and memory dysfunction via the miR-24-3p/Syp axis. These findings revealed circ-Vps41 regulatory network and provided new insights into its potential mechanisms for improving aging-related learning and memory impairment.</p

Additional file 5 of A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis

Additional file 5: Figure S4. Metabolite KEGG pathway enrichment map. Each bubble in the graph represents a KEGG Pathway. The X-axis represents the relative importance of metabolites in the pathway in terms of impact value; the Y-axis represents the enrichment significance of metabolite involvement in the pathway—log10(P value). The size of the bubble represents the Impact value. The larger the bubble, the greater the importance of the pathway. KEGG, Kyoto Encyclopedia of Genes and Genomes

Additional file 2 of A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis

Additional file 2: Figure S1. S-C represents gastric mucosa derived from the control group, and S-LC represents gastric mucosa derived from the liver cirrhosis group. (A) Fig A is the flow chart of the study. (B) Validation of the PLS-DA model using permutation testing. (C) The difference in species composition at the specie level. *p < 0.05, **p < 0.01, and ***p < 0.001

Additional file 3 of A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis

Additional file 3: Figure S2. S-C represents gastric mucosa derived from the control group, and S-LC represents gastric mucosa derived from the treatment group. Wilcoxon rank-sum test bar plot on phylum level. **p < 0.01, and ***p < 0.001. S-C, gastric mucosa in the control group; S-LC, gastric mucosa in patients with cirrhosis