Behavior and activity scores.

<p>Behavior and activity scores.</p

Double labeling of ferritin with CD31(endothelial marker), SWA (a pericyte marker), GFAP (an astrocyte marker), Iba-1 (a microglia marker) and NeuN (a neuron marker)in the cortex at day 3 after subarachnoid hemorrhage.

Scale bar = 20 μm.</p

Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage - Fig 3

<p><b>(A</b>) Occludin immunoreactivity and protein levels in cortex after sham or subarachnoid hemorrhage induction with deferoxamine (DFX) treatment or vehicle at day 3, scale bar = 20μm. Values are mean ± SD; n = 3 for each group, #p<0.01, *p<0.05 vs. SAH+vehicle group at day 3. <b>(B)</b> ZO-1 immunoreactivity and protein levels in cortex after sham or subarachnoid hemorrhage induction with deferoxamine (DFX) treatment or vehicle at day 3, scale bar = 20μm. Values are mean ± SD; n = 3 for each group, #p<0.01 vs. SAH+vehicle group at day 3. <b>(C)</b> Claudin-5 immunoreactivity and protein levels in cortex after sham or subarachnoid hemorrhage induction with deferoxamine (DFX) treatment or vehicle at day 3, scale bar = 20μm. Values are mean ± SD; n = 3 for each group, *p<0.05 vs. SAH+vehicle group at day 3.</p

Ferritin immunoreactivity, and the ferritin heavy chain (FTH) and light chain (FTL) protein levels in cortex at day 3 after sham or subarachnoid hemorrhage induction with deferoxamine (DFX) treatment or vehicle, scale bar = 20μm.

<p>Values are mean ± SD; n = 3 for each group, #p<0.01 vs. SAH+vehicle group at day 3.</p

Biomass-Based N, P, and S Self-Doped Porous Carbon for High-Performance Supercapacitors

Biomass-based hierarchically porous carbon is green and eco-friendly, which exhibits a wide potential for energy storage due to its large specific surface area and multiheteroatoms codoping. Herein, nitrogen (N), phosphorus (P), and sulfur (S) self-doped hierarchically porous carbon (N–P–S-HPC) has been prepared by a one-step method from a peanut meal for the first time. The as-prepared N–P–S-HPC possesses a typical hierarchically porous framework (micropores, mesopores, and macropores) with an extremely large specific surface area (2090 m2 g–1) and N (11.2 atomic %), P (0.82 atomic %), and S (0.64 atomic %) doping. N–P–S-HPC as an electrode for supercapacitors displays an ultrahigh specific capacitance of 525 F g–1 (1 A g–1) with the contributions of electrical double layer capacitance (EDLC) and pseudocapacitance (PC). Remarkably, the capacitance retention of N–P–S-HPC reaches up to 68% (10 A g–1). The N–P–S-HPC//N–P–S-HPC symmetrical supercapacitor delivers a maximum energy density (24.9 Wh kg–1 at 400 W kg–1). After 6000 cycles at 300 mV s–1, the capacitance loss is only 10%, indicating excellent cycling stability of the peanut meal converted N–P–S-HPC, which enables it to be a promising candidate for energy storage and renewable delivery devices

Effect of Ash on Coal Combustion Performance and Kinetics Analysis

In order to explain the influence of the coal ash on the combustion characteristics of coal, the physical and chemical structures of pulverized coal with different ash contents were compared and analyzed, and the combustion characteristics and kinetics of pulverized coal were systematically studied by non-isothermal thermogravimetric analysis. The results show that the physical and chemical structure of the deashed coal is not significantly changed compared with the raw coal. The combustion process of the deashed coal gradually moves to the high temperature zone, and the combustion performance is obviously weakened. The comprehensive combustion characteristic parameters of the three samples can be arranged as: raw coal > primary deashed coal > secondary deashed coal. In this study, the RNGM model was used to analyze the combustion kinetics of pulverized coal, and the fitting effect is good. And there is a significant kinetic compensation effect in the combustion process. After calculation, the activation energy value of the samples is between 16.15~29.51 kJ/mol. The RNGM model can effectively characterize the various stages of the combustion reaction and validate the experimental results.</p

Association of clinicopathologic variables and molecular biomarkers with <i>ERG</i> rearrangement.

<p>Values not available for all 190 cases.</p

Antipermeability Strategy to Achieve Extremely High Specificity and Ultralong Imaging of Diverse Cell Membranes Based on Restriction-Induced Emission of AIEgens

Long-term in situ cell membrane-targeted bioimaging is of great significance for studying specific biological processes and functions, but currently developed membrane probes are rarely simultaneously used to image the plasma membrane of animal and plant cells, and these probes lack sufficiently high long-term targeting ability. Herein, we proposed an antipermeability strategy to achieve highly specific and long-term imaging of plasma membranes of both human and plant cells using the steric hindrance effect and restriction-induced emission of AIE-active probes based on an updated membrane model. A certain degree of rigidity of plasma membrane containing a large ratio of rigid cholesterol molecules in the updated membrane model provides a promising opportunity to design antipermeable probes by introducing a rigid steric hindrance group in the probe. The designed antipermeable probes can anchor inside plasma membrane for a long term relying on the combination of the steric hindrance effect and the electrostatic and hydrophobic interactions between the probe and the membrane, as well as light up the membrane via the restriction-induced emission mechanism. The excellent performance in imaging completeness and specificity for both human cells and plant cells clearly shows that these designed probes possess outstanding antipermeability to achieve long-term specific imaging of membrane. These probes also show some advanced features such as ultrafast staining, wash-free merit, favorable biocompatibility, good photostability, and effective resistance to viscosity and pH alteration. This work also provides a valuable design principle for membrane probes of plant cells that the designed probes require a suitable molecular size favoring the penetration of small pores of cell walls

Kaplan-Meier survival analysis of PCa patients in relation to <i>ERG</i> rearrangement status.

<p>(A) low ki-67 LI (<10%) subgroup, (B) high ki-67 LI (≥10%) subgroup.</p