Monitoring inflammation injuries in the progression of atherosclerosis with contrast enhanced ultrasound molecular imaging - Fig 3

<p>A. Molecular imaging signal intensity (mean±SEM) for VCAM-1 and for control nontargeted microbubbles. Examples of molecular imaging of the ascending aorta and arch in a 32 weeks of age ApoE-/- mouse with (B) VCAM-1–targeted, (C) control microbubbles. * P<0.05 versus control microbubble and compared to corresponding data in wild-type mice.</p

Frequencies of derived haplotypes (≥1%) from six examined polymorphisms of <i>RAC1</i> gene in cases and controls.

<p>Frequencies of derived haplotypes (≥1%) from six examined polymorphisms of <i>RAC1</i> gene in cases and controls.</p

Masson trichrome stains of the ascending aorta in ApoE-/- mice.

<p>(A) Image from ApoE-/- mice at 8 weeks showed mild intimal thickening and sparse monocytes adhesion to the endothelium; (B) Small plaques was detected at 16 weeks; (C) Typical plaques with lipid core formation at 24 weeks; (D) Big plaques with lipid-rich core, necrosis region and inflammatory cells infiltration at 32 weeks. (E) Mean (±SEM) plaque area (ratio to the vessel area) increased with age for ApoE-/- mice (Spearman rank correlation coefficient 0.92; P<0.001). * P<0.05 versus ApoE-/- 8WK. #P<0.05 versus ApoE-/- 16WK. △P<0.05 versus ApoE-/- 24WK. †P<0.05 versus ApoE-/- 32WK.</p

Schematic presentation of the structure of RAC1 gene indicating locations of the analyzed variants (rs836488, rs702482, rs10951982, rs702483, rs6954996, and rs9374).

<p>The RAC1 gene consists of 7 exons (I-VII).</p

Genotype and allele distribution of <i>RAC1</i> gene in renal transplant recipients and healthy subjects.

<p>Genotype and allele distribution of <i>RAC1</i> gene in renal transplant recipients and healthy subjects.</p

Serum lipid profile data (Mean±SD).

<p>Serum lipid profile data (Mean±SD).</p

Stratification analysis of <i>RAC1</i> polymorphisms in renal transplant recipients and healthy subjects.

<p>Stratification analysis of <i>RAC1</i> polymorphisms in renal transplant recipients and healthy subjects.</p

Representative figures of direct sequencing for the six SNPs of <i>RAC1</i> gene.

<p>(A) rs836488, (B) rs702482, (C) rs10951982, (D) rs702483, (E) rs6954996, and (F) rs9374. Allelic variants were indicated by boxes.</p

Linkage disequilibrium results among the six SNPs in <i>RAC1</i> gene.

<p>Linkage disequilibrium results among the six SNPs in <i>RAC1</i> gene.</p

Smart Magnetic Interaction Promotes Efficient and Green Production of High-Quality Fe₃O₄@Carbon Nanoactives for Sustainable Aqueous Batteries

Efficient and green production of monodispersed Fe₃O₄@carbon (C) nanoactives for commercial aqueous battery usage still remains a great challenge due to issues related to tedious hybrid fabrication and purification procedures. Herein, we put forward an interesting applicable synthetic strategy via a general polymeric process and simple magnetic purification treatments, enabling low-cost and massive production of high-quality Fe₃O₄@C hybrids. In such core–shell configurations, all Fe₃O₄ nanoparticles are tightly encapsulated in permeable <i>N</i>-doped C nanoreactors, showing notable nanostructured superiorities as feasible anodes for aqueous batteries. When tested, the Fe₃O₄@C nanoactives exhibit outstanding anodic performance comprising pretty high electrochemical activity/capacity, greatly prolonged cyclic lifespan in contrast to bare Fe₃O₄ counterparts, and prominent rate capabilities. The as-assembled Ni/Fe full cells can even deliver a high energy/power density up to ∼135 Wh kg^–1/11.5 kW kg^–1, further demonstrating their good potential in practical applications. Our smart magnetic purification strategy may hold great promise in addressing critical issues of producing high-quality and affordable Fe₃O₄@C hybrids, not only for energy-storage fields but also in other broad ranges covering catalysts and biosensors