10 research outputs found

    Visualization1.avi

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    A video of 10 high-speed frames with depth map for Fig. 3 in the main paper. Reconstruction of a backward-moving ball

    Visualization2.avi

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    An 800fps 3D video is reconstructed from 80fps measurements shown in Fig.4 in the main paper

    Visualization 1: High-speed compressive range imaging based on active illumination

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    Reconstructed high-speed 3D video Originally published in Optics Express on 03 October 2016 (oe-24-20-22836

    Highly Iso-Selective and Active Catalysts of Sodium and Potassium Monophenoxides Capped by a Crown Ether for the Ring-Opening Polymerization of <i>rac</i>-Lactide

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    Sodium and potassium complexes supported by a bulky monophenoxy with one xanthenyl group at the ortho-position and 18-crown-6 or 15-crown-5 as an auxiliary ligand were synthesized and characterized. These complexes are highly iso-selective and active catalysts for the controlled ring-opening polymerization of <i>rac</i>-lactide. The best isotacticity (<i>P</i><sub>m</sub>) achieved was 0.86, which is the highest iso-selectivity reported to date for an alkali-metal complex. In addition, the corresponding polymer exhibited a high <i>T</i><sub>m</sub> of 182 °C. Furthermore, the polymerization looks like an anti-Arrhenius reaction, which is slower at high temperatures than at low temperatures

    Alkali-Metal Monophenolates with a Sandwich-Type Catalytic Center as Catalysts for Highly Isoselective Polymerization of <i>rac</i>-Lactide

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    Highly isoselective ring-opening polymerization (ROP) of <i>rac</i>-lactide is a challenge for sodium and potassium complexes under mild conditions. In this work, three sodium and potassium complexes with a sandwich-type catalytic center are highly active catalysts for the polymerization of <i>rac</i>-lactide and show high isoselectivities with <i>P</i><sub><i>m</i></sub> values of 0.72–0.82. The best isoselectivity of <i>P</i><sub><i>m</i></sub> = 0.82 is the highest value for alkali-metal complexes under mild conditions. The molecular weights of the obtained PLA are close to the theoretical values, and the molecular weight distributions are narrow

    Alternating Sequence Controlled Copolymer Synthesis of α‑Hydroxy Acids via Syndioselective Ring-Opening Polymerization of <i>O</i>‑Carboxyanhydrides Using Zirconium/Hafnium Alkoxide Initiators

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    The ring-opening polymerization (ROP) of <i>O</i>-carboxyanhydrides (OCAs) can give diverse poly­(α-hydroxy acid)­s (PAHAs) with different functional groups because of easy modification of the side group of OCAs, which can extend applications of PAHAs widely. The stereoselective polymerization of <i>O</i>-carboxyanhydrides and further sequence controlled alternating copolymerization of OCAs were still big challenges until now for lack of suitable catalysts/initiators. In this work, a highly syndioselective ROP of OCAs system as the first stereoselective example in this area is reported using zirconium/hafnium alkoxides as initiators with the highest <i>P</i><sub>r</sub> value up to 0.95. Furthermore, these initiators were successfully applied in the precisely alternating sequence controlled copolymerization of PheOCA and Tyr­(Bn)­OCA, and alternating copolymerization of LacOCA and PheOCA was also achieved

    Stereoselective Alkali-Metal Catalysts for Highly Isotactic Poly(<i>rac</i>-lactide) Synthesis

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    A high degree of chain end control in the isoselective ring-opening polymerization (ROP) of <i>rac-</i>lactide is a challenging research goal. In this work, eight highly active sodium and potassium phenolates as highly isoselective catalysts for the ROP of <i>rac-</i>lactide are reported. The best isoselectivity value of <i>P</i><sub>m</sub> = 0.94 is achieved. The isoselective mechanism is chain-end control through the analysis of the stereoerrors in the microstructure of a final polymer; thus, isotactic multiblock structure polymers are obtained, and the highest melt point can reach 192.5 °C. The donating group in phenolate can clearly accelerate the ROP reaction, potassium complexes are more active than the analogous sodium complexes, and the big spacial hindrance of the ligand can decrease the activity. The high isoselectivities of these complexes mostly result from their sandwich structure constructed by the plane of the crown and the plane of the anthryl group

    Iso-Selective Ring-Opening Polymerization of <i>rac</i>-Lactide Catalyzed by Crown Ether Complexes of Sodium and Potassium Naphthalenolates

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    Two crown ether complexes of sodium and potassium naphthalenolates were synthesized and entirely characterized. The two complexes can iso-selectively catalyze the ring-opening polymerization (ROP) of <i>rac</i>-lactide at room temperature and afford polylactides with desired molecular weights and narrow PDIs; the best isotacticity (<i>P</i><sub>m</sub>) achieved was 0.73

    Data_Sheet_1_Dcf1 Deficiency Attenuates the Role of Activated Microglia During Neuroinflammation.pdf

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    <p>Microglia serve as the principal immune cells and play crucial roles in the central nervous system, responding to neuroinflammation via migration and the execution of phagocytosis. Dendritic cell-derived factor 1 (Dcf1) is known to play an important role in neural stem cell differentiation, glioma apoptosis, dendritic spine formation, and Alzheimer’s disease (AD), nevertheless, the involvement of the Dcf1 gene in the brain immune response has not yet been reported. In the present paper, the RNA-sequencing and function enrichment analysis suggested that the majority of the down-regulated genes in Dcf1<sup>-/-</sup> (Dcf1-KO) mice are immune-related. In vivo experiments showed that Dcf1 deletion produced profound effects on microglial function, increased the expression of microglial activation markers, such as ionized calcium binding adaptor molecule 1 (Iba1), Cluster of Differentiation 68 (CD68) and translocator protein (TSPO), as well as certain proinflammatory cytokines (Cxcl1, Ccl7, and IL17D), but decreased the migratory and phagocytic abilities of microglial cells, and reduced the expression levels of some other proinflammatory cytokines (Cox-2, IL-1β, IL-6, TNF-α, and Csf1) in the mouse hippocampus. Furthermore, in vitro experiments revealed that in the absence of lipopolysaccharide (LPS), the majority of microglia were ramified and existed in a resting state, with only approximately 10% of cells exhibiting an amoeboid-like morphology, indicative of an activated state. LPS treatment dramatically increased the ratio of activated to resting cells, and Dcf1 downregulation further increased this ratio. These data indicated that Dcf1 deletion mediates neuroinflammation and induces dysfunction of activated microglia, preventing migration and the execution of phagocytosis. These findings support further investigation into the biological mechanisms underlying microglia-related neuroinflammatory diseases, and the role of Dcf1 in the immune response.</p
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