180 research outputs found

    Research on Brain and Mind Inspired Intelligence

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    To address the problems of scientific theory, common technology and engineering application of multimedia and multimodal information computing, this paper is focused on the theoretical model, algorithm framework, and system architecture of brain and mind inspired intelligence (BMI) based on the structure mechanism simulation of the nervous system, the function architecture emulation of the cognitive system and the complex behavior imitation of the natural system. Based on information theory, system theory, cybernetics and bionics, we define related concept and hypothesis of brain and mind inspired computing (BMC) and design a model and framework for frontier BMI theory. Research shows that BMC can effectively improve the performance of semantic processing of multimedia and cross-modal information, such as target detection, classification and recognition. Based on the brain mechanism and mind architecture, a semantic-oriented multimedia neural, cognitive computing model is designed for multimedia semantic computing. Then a hierarchical cross-modal cognitive neural computing framework is proposed for cross-modal information processing. Furthermore, a cross-modal neural, cognitive computing architecture is presented for remote sensing intelligent information extraction platform and unmanned autonomous system

    A semi-analytical method for nonlinear vibration of Euler-Bernoulli beams with general boundary conditions

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    This paper presents a new semianalytical approach for geometrically nonlinear vibration analysis of Euler-Bernoulli beams with different boundary conditions. The method makes use of Linstedt-Poincaré perturbation technique to transform the nonlinear governing equations into a linear differential equation system, whose solutions are then sought through the use of differential quadrature approximation in space domain and an analytical series expansion in time domain. Validation of the present method is conducted in numerical examples through direct comparisons with existing solutions, showing that the proposed semianalytical method has excellent convergence and can give very accurate results at a long time interval

    4,8-Dimeth­oxy­furo[2,3-b]quinoline (γ-fagarine)

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    The title mol­ecule, C13H11NO3, a natural compound extracted from Phellodendron chinense, exhibits a near planar framework: the mean deviations from the furo[2,3-b]quinoline ring system and from the whole mol­ecule (not including the H atoms) are 0.006 and 0.062 Å, respectively

    Preventive maintenance optimization policy based on a three-stage failure process in finite time horizon

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    In this paper, a preventive maintenance optimization policy based on a three-stage failure process in finite time horizon is proposed. The lifetime of system is divided into three stages by the concept of three-stage failure process, which is corresponding to the three color scheme commonly used in industry. The subsequent inspection interval is halved when the minor defective stage is identified. Once identifying the severe defective stage, maintenance action is carried out. A numerical example is presented to demonstrate the efficiency of the proposed models

    A joint optimal policy of inspection and age based replacement based on a three-stage failure process

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    Preventive maintenance (PM) and condition-based maintenance (CBM) are two dominant maintenance policies in industrial applications. Inspection activities are the foundation of PM and CBM policies as to provide the operating information of system through processing the collected vibration data. Age based replacement is one of the most used preventive maintenance policy aiming at avoiding unplanned downtime and higher failure loss. This paper proposes a joint optimal policy of inspection and age based replacement based on a three-stage failure process for a single component system. The three-stage failure process, which is closer to reality, divides the failure process of system into three stages: namely normal, minor defective and severe defective. When the severe defective stage is identified, maintenance action is carried out immediately. The system is replaced once it reaches certain age. However, two potential actions are considered and analyzed in this paper when the minor defective stage is identified: halving the subsequent inspection interval or replacing the item immediately. As inspection may not be perfect because of the complexity of plant items, both perfect and imperfect inspection cases are considered. Finally, a case study is presented to demonstrate the efficiency of the proposed models

    A Signal Processing Algorithm Based on 2D Matched Filtering for SSAR

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    This study discusses a smart radar antenna scanning mode that combines features of both the sector-scan mode used for conventional radar and the line-scan mode used for synthetic aperture radar (SAR) and achieves an application of the synthetic aperture technique in the conventional sector-scan (mechanically scanned) radar, and we refer to this mode as sector-scan synthetic aperture radar (SSAR). The mathematical model is presented based on the principle of SSAR, and a signal processing algorithm is proposed based on the idea of two-dimensional (2D) matched filtering. The influences of the line-scan range and speed on the SSAR system are analyzed, and the solution to the problem that the target velocity is very high is given. The performance of the proposed algorithm is evaluated through computer simulations. The simulation results indicate that the proposed signal processing algorithm of SSAR can gather the signal energy of targets, thereby improving the ability to detect dim targets

    An availability model based on a three-stage failure process under age based replacement

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    This paper proposes a joint optimal policy of inspection and age based replacement based on a three-stage failure process to jointly optimize the inspection and replacement intervals. The three-stage failure process divides the failure process of system into three stages: namely normal, minor defective and severe defective. When the minor defective stage is identified, the subsequent inspection interval is halved. Once identifying the severe defective stage, the maintenance action is carried out immediately. The system is replaced once it reaches the certain age. Finally, a numerical example is presented to demonstrate the efficiency of the proposed model

    A non-invasive measurement of tongue surface temperature

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    Oral temperature, tongue specifically, is a key factor affecting oral sensation and perception of food flavour and texture. It is therefore very important to know how the tongue temperature is affected by food consumption. Unfortunately, traditional methods such as clinical thermometers and thermocouples for oral temperature measurement are not most applicable during food oral consumption due to its invasive nature and interference with food. In this study, infrared thermal (IRT) imager was investigated for its feasibility for the measurement of tongue surface temperature. The IRT technique was firstly calibrated using a digital thermometer (DT). The technique was then used to measure tongue surface temperature after tongue was stimulated by (1) water rinsing at different temperatures (0-45℃); and (2) treated with capsaicin solutions (5, 10, and 20 ppm). For both cases, tongue surface temperature showed significant changes as a result of the physical and chemical stimulation. Results confirm that IRT is feasible for tongue temperature measurement and could be a useful supporting tool in future for the study of food oral processing and sensory perception

    Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

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    It has been reported that lactoferrin (LF) participates in the host immune response against Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) invasion by enhancing NK cell activity and stimulating neutrophil aggregation and adhesion. We further investigated the role of LF in the entry of SARS pseudovirus into HEK293E/ACE2-Myc cells. Our results reveal that LF inhibits SARS pseudovirus infection in a dose-dependent manner. Further analysis suggested that LF was able to block the binding of spike protein to host cells at 4°C, indicating that LF exerted its inhibitory function at the viral attachment stage. However, LF did not disrupt the interaction of spike protein with angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV. Previous studies have shown that LF colocalizes with the widely distributed cell-surface heparan sulfate proteoglycans (HSPGs). Our experiments have also confirmed this conclusion. Treatment of the cells with heparinase or exogenous heparin prevented binding of spike protein to host cells and inhibited SARS pseudovirus infection, demonstrating that HSPGs provide the binding sites for SARS-CoV invasion at the early attachment phase. Taken together, our results suggest that, in addition to ACE2, HSPGs are essential cell-surface molecules involved in SARS-CoV cell entry. LF may play a protective role in host defense against SARS-CoV infection through binding to HSPGs and blocking the preliminary interaction between SARS-CoV and host cells. Our findings may provide further understanding of SARS-CoV pathogenesis and aid in treatment of this deadly disease

    The binding pocket properties were fundamental to functional diversification of the GDSL-type esterases/lipases gene family in cotton

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    Cotton is one of the most important crops in the world. GDSL-type esterases/lipases (GELPs) are widely present in all kingdoms and play an essential role in regulating plant growth, development, and responses to abiotic and biotic stresses. However, the molecular mechanisms underlying this functional diversity remain unclear. Here, based on the identification of the GELP gene family, we applied genetic evolution and molecular simulation techniques to explore molecular mechanisms in cotton species. A total of 1502 GELP genes were identified in 10 cotton species. Segmental duplication and differences in evolutionary rates are the leading causes of the increase in the number and diversity of GELP genes during evolution for ecological adaptation. Structural analysis revealed that the GELP family has high structural diversity. Moreover, molecular simulation studies have demonstrated significant differences in the properties of the binding pockets among cotton GELPs. In the process of adapting to the environment, GELPs not only have segmental duplication but also have different evolutionary rates, resulting in gene diversity. This diversity leads to significant differences in the 3D structure and binding pocket properties and, finally, to functional diversity. These findings provide a reference for further functional analyses of plant GELPs
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