Ruthenium-Catalyzed Direct C–H Amidation of Arenes: A Mechanistic Study

We report mechanistic studies of C–H activitation/amidation reactions using azides as the amino source catalyzed by [RuCl₂(<i>p</i>-cymene)]₂. We have achieved two intermediates in the catalytic cycle (C₅H₄NC₆H₄)­Ru­(<i>p</i>-cymene)Cl and (C₅H₄NC₆H₄)­NArRu­(<i>p</i>-cymene)Cl (Ar = NO₂C₆H₄SO₂). Furthermore, the process from (C₅H₄NC₆H₄)­Ru­(<i>p</i>-cymene)Cl to (C₅H₄NC₆H₄)­NArRu­(<i>p</i>-cymene)Cl was monitored by ¹⁹F NMR and a ruthenium–imido species was proposed to explain the formation of the azacyclopropane analogue

Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF₃-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry

Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF₃-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry