Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1)

Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1. We delineate the PKD1 binding sites on HSP20 and show for the first time HSP20 is a substrate for PKD1. Phosphorylation of HSP20 by PKD1 is diminished by pharmacological or siRNA reduction of PKD1 activity and is enhanced following PKD1 activation. Our results suggest that both PKA and PKD1 can both phosphorylate HSP20 on serine 16 but that PKA is the most dominant

Resummation of High Order Corrections in ZZ Boson Plus Jet Production at the LHC

We study the multiple soft gluon radiation effects in $Z$ boson plus jet production at the LHC. By applying the transverse momentum dependent factorization formalism, the large logarithms introduced by the small total transverse momentum of the $Z$ boson plus jet final state system, are resummed to all orders in the expansion of the strong interaction coupling at the accuracy of Next-to-Leading Logarithm(NLL). We also compare the prediction of our resummation calculation to the CMS data by employing a reweighting procedure to estimate the effect from imposing kinematic cuts on the leptons from $Z$ boson decay, and find good agreement for both the imbalance transverse momentum and the azimuthal angle correlation of the final state $Z$ boson and jet system, for $pp\to Z+jet$ production at the LHC.Comment: 7 pages, published versio