Regioisomeric Spirobifluorene CANAL Ladder Polymers and Their Gas Separation Performance

We synthesized and characterized two isomeric microporous hydrocarbon ladder polymers from catalytic arene norbornene annulation (CANAL) of regioisomeric bis-norbornene fused spirobifluorenes, where the ladder chains are connected either through the same fluorene unit or across two different fluorene units in spirobifluorene. This pair of isomeric polymers was used to investigate the effect of ladder macromolecular structures on the microporosity and transport properties. Both polymers form mechanically intact films with thermal stability up to 480 °C and relatively high BET surface areas. The polymer formed from 2,7-dibromospirobifluorene showed higher BET surface area and higher gas permeability than the polymer from 2,2′-dibromospirobifluorene despite similar intersegmental spacing as indicated by X-ray scattering. The aging behavior for both polymers followed the same trend as the previously reported CANAL-fluorene polymers, with dramatically increased permselectivities over time, resulting in gas separation performance above the 2008 upper bounds for H2/CH4 and O2/N2

Importance of Macromonomer Quality in the Ring-Opening Metathesis Polymerization of Macromonomers

Various macromonomers (MMs) were synthesized using controlled radical polymerization (CRP) by either directly growing from a norbornene-functionalized initiator or chain transfer agent (“direct-growth” or DG method) or coupling a norbornenyl group to preformed polymers (“growth-then-coupling” or GC method). The degree of control for the ring-opening metathesis polymerization (ROMP) of these MMs was found to be dependent on which synthetic method was used for the MMs. Narrowly dispersed brush polymers were consistently obtained from the GC-MMs. In contrast, the DG-MMs resulted in brush polymers with a small high-molecular weight (MW) shoulder or broader molecular weight distribution (MWD). Matrix-assisted laser desorption ionization time-of-flight mass spectrometry of DG-MMs showed the presence of a small amount of α,ω-dinorbornenyl telechelic species resulting from the biradical combination during polymerization. A control study further revealed that even the presence of 1 mol % α,ω-norbornenyl telechelic polymer in the MM resulted in broadening of MWD. Our surprising findings suggest the importance of MM quality and the absence of dinorbornenyl telechelic polymers in achieving the best control for high-MW brush polymers via efficient ROMP of MMs

Living Alternating Ring-Opening Metathesis Polymerization Based on Single Monomer Additions

By judiciously modulating the ring strain and sterics, we developed a class of disubstituted cyclopropenes that selectively underwent single monomer addition in ring-opening metathesis but readily underwent alternating ring-opening metathesis polymerization with low-strain cyclic olefins in a living fashion. The substituents on cyclopropenes effectively inhibited homoaddition and prevented secondary metathesis on the polymer backbone. The resulting polymers had controllable molecular weights and end groups, very low dispersities, and high regularity in microstructure under optimized conditions. ¹H and ¹³C NMR spectroscopy and MALDI-TOF MS showed a rigorously alternating sequence. Interestingly, disubstituted cyclopropenes were found to present zero-order kinetics, indicating their rapid single addition and the rate-determining ring opening of the low-strain olefin

Efficient and Facile End Group Control of Living Ring-Opening Metathesis Polymers via Single Addition of Functional Cyclopropenes

Living ROMP has become an important technique for preparing well-controlled, highly functional polymers; however, installing functional groups at the end of living ROMP polymers is not as straightforward as ROMP itself. We report a simple, efficient strategy to introduce functionalities at the chain end of living polynorbornenes via highly selective single addition of disubstituted 1,1-cyclopropenes (CPEs) with no homopropagation. Unlike many other methods for ROMP chain end functionalization, our method does not result in catalyst termination, allowing for further functionalization after CPE addition. The remarkable reactivity of such CPEs allowed for quantitative chain end functionalization to install a variety of useful functionalities, including halides, aldehydes, ketones, amines, and dyes, without using a large excess of CPEs. These polymer chain ends can be readily modified using a range of postpolymerization modifications

sj-docx-1-bhd-10.1177_01987429231179890 – Supplemental material for Behavior Management Training for Newly Graduated Teachers: A Randomized-Controlled Trial

Supplemental material, sj-docx-1-bhd-10.1177_01987429231179890 for Behavior Management Training for Newly Graduated Teachers: A Randomized-Controlled Trial by Stacy N. McGuire, Hedda Meadan and Yan Xia in Behavioral Disorders</p

Synthesis of Cyclobutadienoid-Fused Phenazines with Strongly Modulated Degrees of Antiaromaticity

The streamlined synthesis of a series of regioisomeric azaacene analogues containing fused phenazine and antiaromatic cyclobutadienoids (CBDs), using a catalytic arene–oxanorbornene annulation, followed by aromatization is reported. Controlling the fusion patterns allowed strong modulation of local antiaromaticity. Enhancing antiaromaticity in these regioisomeric azaacenes led to stabilized LUMO, reduced band gap, and quenched fluorescence. This synthetic strategy provides a facile means to fuse CBDs with variable degrees of antiaromaticity onto <i>N</i>-heteroarenes to tune their optoelectronic properties

Molecular Design of a Minimal Peptide Nanoparticle

Nanoparticles are getting a great deal of attention in the rapidly developing field of nanomedicine. For example they can be used as drug delivery systems, for imaging applications, or as carriers for synthetic vaccines. Protein-based nanoparticles offer the advantage of biocompatibility and biodegradability thus avoiding some of the major toxicity concerns with nanoparticle associated approaches. Our group has developed self-assembling peptide/protein nanopartices (SAPNs) that are built up from two coiled-coil oligomerization domains joined by a linker region and used them to design subunit vaccines. For drug delivery approaches the SAPNs need to be as small as possible to avoid strong immune responses that could possibly even lead to anaphylaxis. Here we used a computational and biophysical approach to minimize the size of the SAPNs for their use as drug delivery system. We tested different charge distributions on the pentameric and trimeric coiled-coils in silico with molecular dynamics simulations to down-select an optimal design. This design was then investigated in vitro by biophysical methods and we were able to engineer a minimal SAPN of only 11 nm in diameter. Such minimal-sized SAPNs offer new avenues for a safer development as drug delivery systems or other biomedical applications

Functionalized Rigid Ladder Polymers from Catalytic Arene-Norbornene Annulation Polymerization

Rigid ladder polymers represent a unique polymer architecture but have limited synthetic accessibility and structural diversity. Using catalytic arene-norbornene annulation (CANAL) polymerization, we synthesized ladder polymers consisting of rigid and kinked norbornyl benzocyclobutene backbones and bearing various functional groups, such as alcohol, amine, ester, carbamate, amide, benzyl bromide, azide, and heterocycles. The incorporation of functional groups was achieved by either copolymerization of functionalized ladder-type dinorbornenes or postpolymerization functionalization. Functionalization of ladder polymers allows modification of their solubility, compatibility, and other properties, expanding their utilities. These ladder polymers remain microporous and highly glassy, which are desirable for separation and high-temperature applications

Regioselective Synthesis of [3]Naphthylenes and Tuning of Their Antiaromaticity

Polycyclic conjugated hydrocarbons containing four-membered cyclobutadienoids (CBDs) are of great fundamental and technical interest due to the antiaromaticity brought by CBD circuits. However, their synthesis has been challenging, hampering the exploration and understanding of such systems. We report efficient synthesis of a series of unprecedented [3]­naphthylene regioisomers in high yields, where three naphthalenoids are fused through two CBDs in linear, angular, and bent regioconnectivity. Their synthesis was enabled by exclusively regioselective catalytic arene–norbornene annulation (CANAL) between dibromonaphthalenes and benzooxanorbornadienes, followed by aromatization. [3]­Naphthylene regioisomers exhibited distinct optoelectronic properties. Nucleus-independent chemical shift calculations, NMR spectroscopy, and X-ray crystallography revealed the strong effect of the fusion pattern on the local antiaromaticity and aromaticity in fused CBDs and naphthalenoids, respectively. Thus, our synthetic strategy allows facile access to extended CBD-fused π-systems with tunable local antiaromaticity and aromaticity