Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer

Aryl hydrocarbon receptor (AHR) plays an important role in tumor development. However, its function in cervical cancer has not been fully elucidated. We evaluated the ten genes that are predicted to associate with AHR protein interaction. The comprehensive scores were: CYP1A1, ARNT2, HSP90AA1, ARNT, AIP, PTGES3, HSP90AB1, CYP1B1, ESR1, MAF, respectively. In addition, we showed that levels of AHR and its related genes were correlated with the immune infiltration and expression of immuno-regulators (immunoinhibitors, immunostimulators, MHC molecules) levels in cervical cancer. High expression of AHR, CYP1A1, HSP90AA1, and HSP90AB1 and low expression of ESR1 were negatively correlated with the prognoses of cervical cancer patients. The Cox multivariate regression showed that high expression of AHR (HR = 1.874, 95% CI = 1.069–3.285, P= 0.028) and CYP1A1 (HR = 1.822, 95%CI = 1.077–3.080, P= 0.025) were risk factors for prognosis in patients with cervical cancer. IHC results indicated that AHR and CYP1A1 were widely expressed in cervical cancer. These findings suggest that AHR and CYP1A1 may serve as prognostic biomarkers for determining prognosis and immune infiltration in cervical cancer.</p

Presentation1_Shale Reservoir 3D Structural Modeling Using Horizontal Well Data: Main Issues and an Improved Method.pdf

Shale oil and gas fields usually contain many horizontal wells. The key of 3D structural modeling for shale reservoirs is to effectively utilize all structure-associated data (e.g., formation tops) in these horizontal wells. The inclination angle of horizontal wells is usually large, especially in the lateral section. As a result, formation tops in a horizontal well are located at the distinct lateral positions, while formation tops in a vertical well are usually stacked in the same or similar lateral position. It becomes very challenging to estimate shale layer thickness and structural map of multiple formation surfaces using formation tops in horizontal wells. Meanwhile, the large inclination angle of horizontal wells indicates a complicated spatial relation with shale formation surfaces. The 3D structural modeling using horizontal well data is much more difficult than that using vertical well data. To overcome these new challenges in 3D structural modeling using horizontal well data, we developed a method for 3D structural modeling using horizontal well data. The main process included 1) adding pseudo vertical wells at formation tops to convert the uncoupled formation tops to coupled formation tops as in vertical wells, 2) estimating shale thickness by balancing the shale thickness and dip angle change of a key surface, and 3) detecting horizontal well segments landing in the wrong formations and adding pseudo vertical wells to fix them. We used our improved method to successfully construct two structural models of Longmaxi–Wufeng shale reservoirs at a well pad scale and a shale oil/gas field scale. Our research demonstrated that 3D structural modeling could be improved by maximizing the utilization of horizontal well data, thus optimizing the quality of the structural model of shale reservoirs.</p

Unadjusted and adjusted factors associated with all-cause mortality among HIV-positive injection drug users initiating highly active antiretroviral therapy in British Columbia, between June 1998 and Sept 2011 (n = 254).

1<p>Hazard Ratio</p>2<p>95% Confidence Interval</p>3<p>Adjusted Hazard Ratio</p>4<p>Highly active antiretroviral therapy</p>5<p>Protease Inhibitor</p>6<p>Within the last 12 months of interview</p

Adjusted cumulative incidence of all-cause mortality among HIV-positive injection drug users initiating antiretroviral therapy in British Columbia, stratified by hunger status.

<p>Adjusted cumulative incidence of all-cause mortality among HIV-positive injection drug users initiating antiretroviral therapy in British Columbia, stratified by hunger status.</p

Adjusted cumulative incidence of all-cause mortality among HIV-positive injection drug users initiating antiretroviral therapy in British Columbia, stratified by food security status.

<p>Adjusted cumulative incidence of all-cause mortality among HIV-positive injection drug users initiating antiretroviral therapy in British Columbia, stratified by food security status.</p

Baseline characteristics among HIV-positive injection drug users initiating antiretroviral therapy across British Columbia, by food security status, between June 1998 and Sept 2011 (n = 254).

1<p>Inter-quartile range</p>2<p>Highly active antiretroviral therapy use</p>3<p>Protease Inhibitor-based regimen</p>4<p>Within last 12 months of interview</p

Data_Sheet_1_Effects of Electroacupuncture Combined With Psychological Intervention on Depressive Status and Contingent Negative Variation in Patients With Internet Addiction Disorder: A Randomized Controlled Trial.PDF

Background: Depressive symptoms often accompany people with Internet addiction syndrome (IAD). Acupuncture has been found to have significant advantages in improving the severity and depressive symptoms of IAD. Contingent negative variation (CNV) is a common method to explore the mechanism of neurophysiology.Objective: The purpose of this study was to observe the efficacy of electroacupuncture (EA), psychological intervention (PI), and comprehensive intervention (CI) in the treatment of depression in Internet addiction disorder (IAD), and to observe the changes of contingent negative variation (CNV) in each group.Methods: One hundred and twenty subjects diagnosed with IAD were randomly assigned to the EA group, the PI group, or the CI group. They received EA, PI, or a combination of EA and PI for 40 days. The Internet Addiction Test (IAT), the Zung Self-rating Depression Scale (SDS), and the Hamilton Depression Scale (HAMD) were evaluated for all subjects at baseline, 20th, and 40th days of treatment, while CNV data were collected at baseline and 40th days of treatment.Results: Three treatments effectively reduced IAT, SDS, and HAMD scores, and the intergroup comparison showed that CI was superior to EA, while EA was superior to PI. CNV results indicated that the CNV amplitude increased in all three groups of IAD patients after treatment. The CNV latency of point A and A-S2' wave area of the EA group and the CI group did not change significantly after treatment. Only the A-S2' wave area of the PI group increased significantly compared with the baseline period. In addition, IAD's IAT score was positively correlated with SDS and HAMD score at baseline but negatively correlated with CNV latency. After treatment, only the change of HAMD score in the CI group was negatively correlated with amplitude.Conclusion: Our results demonstrate the efficacy of acupuncture and psychological intervention in the treatment of IAD from an electrophysiological perspective. Simultaneously, the increase in CNV amplitude might be the underlying neurophysiological mechanism by which CI improves depression and cognitive function in IAD patients.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT02362698.</p