991 research outputs found

    The role of autoimmune reactions in formation and progressing of Sjogren’s syndrome as systemic damage of organism

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    The purpose of the research was the identification of association of organs and systems damage in Sjogren’s syndrome with the presence of organ-specific and organnonspecific autoantibodies. On the basis of complex examination of 21 patients with Sjogren’s syndrome (women age 53,5 ± 0,9 years old) and content determination of wide spectrum of organ-specific and organ-nonspecific autoantibodies we estimated the existence of association between presence of these autoantibodies and clinical manifestations of Sjogren’s syndrome. The received results demonstrate the relationship between the expressiveness of inflammatory manifestations and the content of antibodies to DNA. The expressiveness of salivary glands injuries is associated with content of autoantibodies to salivary glands. The presence of associated diseases is also associated with existence of particular autoantibodies. As in all examined patients with Sjogren’s syndrome was present the digestive tract pathology, it can be assumed that changes in digestive tract wall lead to damage of immune system structures and polyclonal uncontrollable activation of antibodies production

    The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer

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    Colorectal cancer (CRC) ranks 2nd in the structure of mortality from malignant neoplasms (MN). One of the criteria for the prognosis of CRC may be a tumor stroma, which has not been widely used in clinical practice. The aim was to determine the main morphological features of the stroma CRC T3N0-2M0 and search for prognostic criteria for their recurrence and lethal outcome according to the operating material and autopsy. Materials and methods. Group I included primary CRC without recurrence. The average recurrence-free period was 5 years (62.5±16.5 months). Group II – primary CRC with recurrence; IIA – with recurrences within 5 years from the date of tumor removal that did not lead to death; IIB – with the appearance of recurrence and lethal consequence of the generalization of the tumor process within 5 years from the moment of removal of the primary tumor. CRC micropreparations made according to the standard method with G + E staining were studied; immunohistochemical study was performed using monoclonal antibodies to smooth muscle actin alpha. Results. Stromal-parenchymal ratio >50 % is a prognostic criterion for recurrence (p<0.05) and shorter recurrence-free survival (p<0.001) of patients with stage IIA-IIIB CRC. Immature stroma type CRC stage IIA-IIIB is associated with the presence of tumor budding (p<0.001), G3 differentiation (p<0.01), shorter recurrence-free survival (p<0.001); among recurrent CRCs, the immature type of stroma is associated with the lethal outcome of patients (p<0.05). Expressed levels of tumor-activated fibroblasts are one of the criteria for immature CRC stroma (p<0.003), but as an independent prognostic criterion has limited prognostic value. Conclusions. TSR and immature type of stroma are prognostic criteria for recurrence and recurrence period of CRC pT3N0-2M0, more typical of tumors of patients with recurrence and lethal outcome with the same ratio of tumors by differentiation

    Assessment of Nighttime Airborne Visual ASW Capability

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    NPS NRP Project PosterHaving an unmanned aircraft to investigate possible surface and underwater contacts ahead of a transiting strike group is considered a valuable and urgently needed tool to complement other available sensors to identify a threat (in the case of Anti-Submarine Warfare (AFW)) and/or avoid collision. The hypothesis evaluated in this study is whether modern commercial off-the-shelf (COTS) small unmanned aerial system (sUAS) equipped with a miniaturized COTS low-light night-vision (LLNV) imagers could ultimately provide this capability. Ideally, this study would benefit from using a highly efficient electric vertical takeoff and landing fixed-wing COTS sUAS which can be launched even from a small ship deck, including those operated by Monterey Bay Aquarium Research Institute (MBARI). This sUAS features extremely low noise emission, can stay in the area for 90+ minutes, carry wide range of high precision sensors and cover large areas. It can transmit telemetry at up to 7 km C2 range, and can potentially provide encoded live video stream at 5mb/s (using an encrypted broadband mesh IP network). However, many constrains associated with cyber security, ship operations, airspace may prevent from employing sUAS in this study. The envisioned alternative platform to be used to evaluate feasibility of the overall concept is a general aviation aircraft equipped to collect low-light imagery. The research questions this study may address are as follows: 1. What are the limits of the current airborne LLNV sensors for nighttime detection of underwater objects? 2. Would the use of spectral, spatial and temporal filters would enhance target signature enough to create image database and use it for identification purposes? 3. What are the atmospheric / water condition contributing to emission of light from living organisms? 4. Whether it is feasible to integrate a COTS wavelength-optimized LLNV sensor with a COTS sUAS to provide a viable nighttime detection capability for shallow-swimming biologics and objects? The study will present the overall concept, discuss integration issues and issues associated with operating in the National airspace, specifically within the Monterey Bay area at nighttime; followed by assessing shallow-swimming whale imagery coming out of a typical COTS LLNV sensor. Based on the quality, quantity and variety of the collected samples, this study may include creating an image database and artificial-intelligence based qualifier to distinguish different objects (species) based on their bioluminescent signature. It is expected to collaborate with several external organizations; involve SE, OC and MR students; and summarize all the findings in the final report.Naval Surface and Mine Warfighting Development Center (SMWDC)U.S. Fleet Forces Command (USFF)This research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.
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