Fatigue of a polycrystalline nickel based superalloy: numerical simulation and physical experiment

Thermo-mechanical fatigue of a polycrystalline nickel based superalloy was studied by numerical simulation and physical experiment in order to understand effects of temperature, applied stress, and processing residual stress on microstructure degeneration and mechanical deterioration of key components in aircraft engine

DataSheet_1_A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis.zip

Background and aimsPrimary biliary cholangitis (PBC) is a progressive chronic autoimmune cholestatic liver disease characterized by the destruction of small intrahepatic bile ducts leading to biliary cirrhosis. Liver biopsy is required in the diagnosis of Antimitochondrial antibody-negative patients. Therefore, novel biomarkers are needed for the non-invasive diagnosis of PBC. To identify novel biomarkers for PBC, we conducted large-scale plasma proteome Mendelian randomization (MR).MethodsA total of 21,593 protein quantitative trait loci (pQTLs) for 2297 circulating proteins were used and classified into four different groups. MR analyses were conducted in the four groups separately. Furthermore, the results were discovered and replicated in two different cohorts of PBC. Colocalization analysis and enrichment analysis were also conducted.ResultsThree plasma proteins (ficolin-1, CD40 and protein FAM177A1) were identified and replicated as being associated with PBC. All of them showed significant protective effects against PBC. An increase in ficolin-1 (OR=0.890 [0.843-0.941], p=3.50×10-5), CD40 (OR=0.814 [0.741-0.895], p=1.96×10-5) and protein FAM177A1 (OR=0.822 [0.754-0.897], p=9.75×10-6) reduced the incidence of PBC. Ficolin-1 (PP4 = 0.994) and protein FAM177A1 (PP4 = 0.995) colocalized with the expression of the genes FCN1 and FAM177A1 in whole blood, respectively. Furthermore, CD40 (PP4 = 0.977) and protein FAM177A1 (PP4 = 0.897) strongly colocalized with PBC.ConclusionsWe expand the current biomarkers for PBC. In total, three (ficolin-1, CD40, and protein FAM177A1) plasma proteins were identified and replicated as being associated with PBC in MR analysis. All of them showed significant protective effects against PBC. These proteins can be potential biomarkers or drug targets for PBC.</p

MOESM1 of A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease

Additional file 1: Table S1. Questions of the frequency of scale for the symptoms of GERD (FSSG). Table S2. Newcastle-Ottawa Scale of the Cohort Studies Included in the Meta-analysis. Table S3. Quality assessment of the cross-sectional studies Included in the Meta-analysis by Agency for Healthcare Research and Quality (AHRQ) *. Figure S1. Funnel plot of meta-analysis. Figure S2. Forest plot of mean difference of frequency of exacerbation in COPD patients with and without GERD under fixed model

Components of the 3D ear acqusition system.

<p>Components of the 3D ear acqusition system.</p

3D ear acquisition system: (a) Our developed 3D ear acquisition device, (b) 2D ear images with laser lines on them, and (c) 3D ear points cloud sample

<p>3D ear acquisition system: (a) Our developed 3D ear acquisition device, (b) 2D ear images with laser lines on them, and (c) 3D ear points cloud sample</p

Illustration of one-step rotation in laser scanning.

<p>Illustration of one-step rotation in laser scanning.</p

3D ear acquisition system: (a) Our developed 3D ear acquisition device, (b) 2D ear images with laser lines on them, and (c) 3D ear points cloud sample

<p>3D ear acquisition system: (a) Our developed 3D ear acquisition device, (b) 2D ear images with laser lines on them, and (c) 3D ear points cloud sample</p

Specifications of core components.

<p>Specifications of core components.</p

Performance Comparison with commercial scanner (Vivid 910).

<p>Performance Comparison with commercial scanner (Vivid 910).</p

Illustration of parameters variation with different subdivision numbers.

<p>Illustration of parameters variation with different subdivision numbers.</p