Pyridineselenolate Complexes of Copper and Indium: Precursors to CuSe<i>_x</i> and In₂Se₃

The pyridineselenolate (2-Se-NC5H4, (SePy)) and the 3-(trimethylsilyl)pyridineselenolate (3-Me3Si-2-Se-NC5H4 (SePy*)) ligands form air-stable homoleptic coordination compounds of Cu(I) { [Cu(SePy)]4 (1) and [Cu(SePy*)]4 (2)} and In(III) {In(SePy)3 (3) and In(SePy*)3 (4)}. Mass spectroscopic characterization of the Cu(I) compounds indicated a tetrametallic core, and this was confirmed with a single-crystal X-ray structural characterization of crystalline 1 and 2, which both contain a tetrametallic cluster of Cu(I) ions bound to two doubly bridging Se atoms and a pyridine nitrogen. The Cu coordination sphere is completed with two strong Cu−Cu bonds and one weaker Cu−Cu interaction. The indium compounds 3 and 4 are each distorted fac-octahedral molecules with chelating SePy ligands. These compounds are useful low-temperature precursors to the binary selenides. Both 3 and 4 sublime intact; 3 thermally decomposes to give In2Se3. The Cu clusters do not sublime intact but still decompose to give metal selenide phases:  2 decomposes to give pure α-CuSe at low temperatures and increasing amounts of Cu2-xSe at elevated temperatures, while 3 decomposes to give a mixture of CuSe phases at all temperatures. Crystal data (Mo Kα:  1, 153(5) K; 2−4, 293(2) K) are as follows:  1, monoclinic space group C2/c, a = 20.643(5) Å, b = 16.967(2) Å, c = 16.025(2) Å, β = 114.16(2)°, Z = 8; 2, tetragonal space group I41/a, a = 14.756(3) Å, c = 19.925(3) Å, Z = 4; 3, trigonal space group P3̄c1, a = 13.352(2) Å, c = 13.526(2) Å, Z = 4; 4, monoclinic space group P21/c, a = 9.793(1) Å, b = 20.828(6) Å, c = 16.505(1) Å, β = 96.69(1)°, Z = 4

sj-tif-2-jdr-10.1177_00220345211051594 – Supplemental material for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation

Supplemental material, sj-tif-2-jdr-10.1177_00220345211051594 for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation by W. Cai, Y. Ji, L. Han, J. Zhang, Y. Ni, Y. Cheng and Y. Zhang in Journal of Dental Research</p

sj-docx-1-jdr-10.1177_00220345211051594 – Supplemental material for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation

Supplemental material, sj-docx-1-jdr-10.1177_00220345211051594 for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation by W. Cai, Y. Ji, L. Han, J. Zhang, Y. Ni, Y. Cheng and Y. Zhang in Journal of Dental Research</p

sj-tif-3-jdr-10.1177_00220345211051594 – Supplemental material for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation

Supplemental material, sj-tif-3-jdr-10.1177_00220345211051594 for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation by W. Cai, Y. Ji, L. Han, J. Zhang, Y. Ni, Y. Cheng and Y. Zhang in Journal of Dental Research</p

sj-tif-4-jdr-10.1177_00220345211051594 – Supplemental material for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation

Supplemental material, sj-tif-4-jdr-10.1177_00220345211051594 for METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation by W. Cai, Y. Ji, L. Han, J. Zhang, Y. Ni, Y. Cheng and Y. Zhang in Journal of Dental Research</p

Media 1: Optical pacing of the adult rabbit heart

Originally published in Biomedical Optics Express on 01 September 2013 (boe-4-9-1626

DC Breakdown voltage tests may not be a good indicator of long-Term ageing behaviour: A study of silica - XLPE nanocomposites

Legacy description not available</p

SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids

Oxidative stress and mitochondrial dysfunction are hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Silent information regulator 1 (SIRT1) attenuates oxidative stress and improves mitochondrial biogenesis in numerous mitochondrial-related diseases; however, a functional role for SIRT1 in chronic liver cholestasis, characterized by increased levels of toxic bile acids, remains unknown. We show decrease in SIRT1 levels and its activity and impairment of mitochondrial biogenesis in the liver of patients with extrahepatic cholestasis. Moreover, we found that glycochenodeoxycholic acid (GCDCA) stimulated cytotoxicity, disrupted the mitochondrial membrane potential, increased reactive oxygen species production, and decreased mitochondrial mass and mitochondrial DNA content in L02 cells. Consistent with this finding, GCDCA was found to decrease SIRT1 protein expression and activity, thus promoting the deacetylation of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α), a key enzyme involved in mitochondrial biogenesis and function. Conversely, GCDCA-induced mitochondrial injury was efficiently attenuated by SIRT1 overexpression. In summary, these findings indicate that the loss of SIRT1 may play a crucial role in the pathogenesis of liver damage observed in patients with extrahepatic cholestasis. The findings also indicate that genetic supplementation of SIRT1 can ameliorate GCDCA-induced hepatotoxicity through the activation of PGC-1α-dependent mitochondrial biogenesis.</p

DC Breakdown voltage tests may not be a good indicator of long-Term ageing behaviour: A study of silica - XLPE nanocomposites

Legacy description not available</p

Comparison of Elemental Carbon in Lake Sediments Measured by Three Different Methods and 150-Year Pollution History in Eastern China

Concentrations of elemental carbon (EC) were measured in a 150 yr sediment record collected from Lake Chaohu in Anhui Province, eastern China, using three different thermal analytical methods: IMPROVE_A thermal optical reflectance (TOR), STN_thermal optical transmittance (TOT), and chemothermal oxidation (CTO). Distribution patterns for EC concentrations are different among the three methods, most likely due to the operational definition of EC and different temperature treatments prescribed for each method. However, similar profiles were found for high-temperature EC fractions among different methods. Historical sootTOR (high-temperature EC fractions measured by the IMPROVE_A TOR method) from Lake Chaohu exhibited stable low concentrations prior to the late 1970s and a sharp increase thereafter, corresponding well with the rapid industrialization of China in the last three decades. This may suggest that high-temperature thermal protocols are suitable for differentiating between soot and other carbon fractions. A similar sootTOR record was also obtained from Lake Taihu (∼200 km away), suggesting a regional source of soot. The ratio of charTOR (low-temperature EC fraction measured by the IMPROVE_A TOR method, after correction for pyrolysis) to sootTOR in Lake Chaohu shows an overall decreasing trend, consistent with gradual changes in fuel use from wood burning to increasing fossil fuel combustions. Average higher charTOR/sootTOR was observed in Lake Taihu than in Lake Chaohu in the past 150 years, consistent with the longer and more extensive industrialization around the Taihu region