Table_1_The effect of basic medical insurance on the changes of primary care seeking behavior: An application of hierarchical age-period-cohort analysis.docx

In order to encourage residents to go to primary care facilities, China has set up differentiated basic medical insurance reimbursement ratios. The study aims to use the dynamic point of view of longitudinal data to examine the changes in the impact of basic medical insurance on primary care. The data for this study comes from the Chinese Family Panel Study (CFPS) in 2010, 2012, 2014, 2016, and 2018. We adopted Hierarchal Age-period-cohort-Cross-Classified Random Effects Models (HAPC-CCREM) to examine the changes in the impact of basic medical insurance on primary care. Compared with non-insured groups, participants of the New Rural Cooperative Medical System (coefficient = 0.730) have a relatively high incidence of primary care seeks, while Urban Residents' Basic Medical Insurance (coefficient = −0.482) and Urban Employees' Basic Medical Insurance (coefficient = −0.663) are lower, respectively. Age, period over time and cohort have a more obvious moderating effect on primary care seeks. The study of primary care behavior is an important direction for the construction of a hierarchical medical system. As basic medical insurance is the source of power for the hierarchical medical system, we can provide certain direction for policy formulation on the changes of basic medical insurance in primary care behavior.</p

Reaction Mechanisms of Photoinduced Quinone Methide Intermediates Formed via Excited-State Intramolecular Proton Transfer or Water-Assisted Excited-State Proton Transfer of 4‑(2-Hydroxyphenyl)pyridine

Femtosecond and nanosecond transient absorption spectroscopies combined with theoretical calculations were performed to investigate the formation mechanisms of quinone methides (QMs) from 4-(2-hydroxyphenyl)­pyridine (1). In acetonitrile (ACN), the singlet excited state of 1 (1(S1)) with the cis-form underwent a thermodynamically favorable and ultrafast ESIPT to produce the singlet excited state QM, which could either relax first into highly vibrational states of its ground state followed by hydrogen transfer to return to the starting compound or alternatively may undergo a dehydrogenation to produce a radical species (1-R). In ACN–H2O, 1(S1) interacted with water molecules to form a solvated species, which induced water-assisted ESPT to the pyridine nitrogen to generate the singlet excited state QM in a concerted asynchronous manner that was initiated by deprotonation of the phenolic OH. These results provide deeper insights into the formation mechanisms of QMs in different solvent environments, which is important in the application of QMs in biological and chemical systems as well as in the design of molecules for efficient QM formation

Intramolecular Photoredox Reaction Mechanism of Naphthoquinone Compounds: Combined Time-Resolved Spectroscopies and DFT Calculations

Time-resolved spectroscopies and DFT calculations were utilized to investigate the photoredox mechanisms of naphthoquinone compounds. 5-Methoxy-8-tetrahydropyrane-1,4-naphthoquinone (NQ) and 2-methyl-3-(3-methylbut-2-en-1-yl) 1,4-naphthoquinone (MNQ) were excited to singlet excited species (labeled NQ­(S1) and MNQ­(S1), respectively). NQ­(S1) underwent intersystem crossing to produce a triplet NQ, which further underwent hydrogen atom transfer to form a biradical intermediate. The biradical underwent electron transfer to form a zwitterion, followed by cyclization and proton transfer to generate a photoproduct. MNQ­(S1) underwent a 1,4-proton transfer process to produce a quinone methide intermediate (1,3-QM) with zwitterionic character, which tautomerized to 1,2-QM. Then, 1,2-QM underwent electrocyclization. The substituent on the parent naphthoquinone is the key factor leading to the different reaction processes for NQ and MNQ

Overcoming the strength-ductility trade-off in metastable dual-phase heterogeneous structures using variable temperature rolling and annealing

A novel variable temperature rolling (VTR) and annealing process was conducted on a metastable austenitic stainless steel. Strain softening occurred during tensile straining in both cold rolled and cryogenic rolled-annealed steels, leading to low uniform elongations of only 2-3%. In contrast, thanks to the metastable dual-phase heterogeneous lamellar structure achieved via the VTR process, a ultra-high strength of over 1 GPa was obtained, and strain hardening led to a remarkable increase of uniform elongation up to 10%. The high strength and ductility are attributed to the significant work-hardening derived from the superior heterogeneous deformation-induced hardening and sustained transformation-induced plasticity effect. We identify a new variable temperature rolling and annealing process to achieve a metastable dual-phase heterogeneous lamellar structure, which overcomes strength-ductility trade-off by coupling of HDI hardening and TRIP effect.</p

3D Chiral Energy-Absorbing Structures with a High Deformation Recovery Ratio Fabricated via Selective Laser Melting of the NiTi Alloy

Excellent energy-absorbing structures have been highly sought after in engineering applications to improve devices and personal safety. The ideal energy absorption mechanism should exhibit characteristics such as lightweight, high energy absorption capacity, and efficient reusability. To address this demand, a novel three-dimensional (3D) chiral lattice structure with compression-twist coupling deformation is fabricated by combining the left and right chiral units. The proposed structure was fabricated in NiTi shape memory alloys (SMAs) by using laser powder bed fusion technology. The compression experiment result indicates that the shape recovery ratio is as high as 94% even when the compression strain is over 80%. Additionally, the platform strain reaches as high as 66%, offering high-level specific energy absorption, i.e., 213.02 J/g. The obtained results are of great significance for basic research and engineering applications of energy-absorbing structures with high deformation recovery ratios

3D Chiral Energy-Absorbing Structures with a High Deformation Recovery Ratio Fabricated via Selective Laser Melting of the NiTi Alloy

Excellent energy-absorbing structures have been highly sought after in engineering applications to improve devices and personal safety. The ideal energy absorption mechanism should exhibit characteristics such as lightweight, high energy absorption capacity, and efficient reusability. To address this demand, a novel three-dimensional (3D) chiral lattice structure with compression-twist coupling deformation is fabricated by combining the left and right chiral units. The proposed structure was fabricated in NiTi shape memory alloys (SMAs) by using laser powder bed fusion technology. The compression experiment result indicates that the shape recovery ratio is as high as 94% even when the compression strain is over 80%. Additionally, the platform strain reaches as high as 66%, offering high-level specific energy absorption, i.e., 213.02 J/g. The obtained results are of great significance for basic research and engineering applications of energy-absorbing structures with high deformation recovery ratios

Dual-Modulated Polyamide Membranes Based on Vapor–Liquid Interfacial Polymerization for CO₂ Separation

Polyamide (PA) membranes show great application potential in the CO2 separation study. However, the PA membranes prepared by the traditional interfacial polymerization (IP) have a dense microstructure and a singularity of functional groups, making it difficult to exhibit both high CO2 permeance and selectivity. Herein, we report a new dual-modulation strategy by preparation method optimization and filler modification to improve the CO2 separation performance of the PA membranes. The PA membranes prepared by vapor–liquid IP have a loose microstructure, which greatly improves the gas permeance. The introduction of mono-(6-ethanediamine-6-deoxy)-beta-cyclodextrin (CD) can better loosen the PA microstructure, and the CO2-philic groups in the CD boost the CO2 selectivity by the facilitated transport effect. Ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate is further sealed into PA membranes to remedy the possible microvoids or defects and CD cavities of the membrane microstructure. The prepared membranes display excellent CO2 separation performance with CO2/H2, CO2/CH4, and CO2/N2 selectivity of 8.2, 45.5, and 116.9, as well as a CO2 permeance of about 320 GPU. The proposed strategy provides a facile and effective route to dual-modulated PA membranes for the study of CO2 separation and can be expanded to other macrocyclic molecules and ionic liquid systems

Image_1_Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation.pdf

With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars. Hub genes that determine the phenotypes of CRC become essential for targeted therapy. In the present study, the importance of cyclin-dependent kinases (CDKs) on the occurrence of CRC was identified by data mining of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The results showed that the gene expression levels of CDK1, CDK4, and CDK6 were obviously changed in different stages of CRC. Among the CDKs, CDK4 was suggested as an independent risk factor for CRC based on Cox analysis. Furthermore, chondroitin sulfate (CS), a kind of dietary supplement to treat osteoarthritis, was predicted to treat CRC based on its chemical structure and GEO datasets. Cell assay experiments with the human CRC cell line HCT-116 also verified this prediction. CS inhibited the gene and protein expression levels of CDKs and increased the ratios of apoptotic or dead HCT-116 cells by regulating mitogen-activated protein (MAP) kinase pathways. Our data highlight the essential roles of CDKs in CRC carcinogenesis and the effects of CS on treating CRC, both of which will contribute to the future CRC treatment.</p

3D Chiral Energy-Absorbing Structures with a High Deformation Recovery Ratio Fabricated via Selective Laser Melting of the NiTi Alloy

Excellent energy-absorbing structures have been highly sought after in engineering applications to improve devices and personal safety. The ideal energy absorption mechanism should exhibit characteristics such as lightweight, high energy absorption capacity, and efficient reusability. To address this demand, a novel three-dimensional (3D) chiral lattice structure with compression-twist coupling deformation is fabricated by combining the left and right chiral units. The proposed structure was fabricated in NiTi shape memory alloys (SMAs) by using laser powder bed fusion technology. The compression experiment result indicates that the shape recovery ratio is as high as 94% even when the compression strain is over 80%. Additionally, the platform strain reaches as high as 66%, offering high-level specific energy absorption, i.e., 213.02 J/g. The obtained results are of great significance for basic research and engineering applications of energy-absorbing structures with high deformation recovery ratios

Table_1_Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation.pdf

With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars. Hub genes that determine the phenotypes of CRC become essential for targeted therapy. In the present study, the importance of cyclin-dependent kinases (CDKs) on the occurrence of CRC was identified by data mining of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The results showed that the gene expression levels of CDK1, CDK4, and CDK6 were obviously changed in different stages of CRC. Among the CDKs, CDK4 was suggested as an independent risk factor for CRC based on Cox analysis. Furthermore, chondroitin sulfate (CS), a kind of dietary supplement to treat osteoarthritis, was predicted to treat CRC based on its chemical structure and GEO datasets. Cell assay experiments with the human CRC cell line HCT-116 also verified this prediction. CS inhibited the gene and protein expression levels of CDKs and increased the ratios of apoptotic or dead HCT-116 cells by regulating mitogen-activated protein (MAP) kinase pathways. Our data highlight the essential roles of CDKs in CRC carcinogenesis and the effects of CS on treating CRC, both of which will contribute to the future CRC treatment.</p