Significantly different species analysis on the family level and genus level.

A: Analysis of significantly different species at the family level; B: Analysis of significantly different species at the genus level (*, P < 0.05; **, P <0 .01; ***, P <0 .001).</p

Formula of high cellulose feed.

(DOCX)</p

High-fiber diet can reduce lung inflammation and related cytokine production.

A: The pulmonary inflammation in the AS group was significantly worse than that in the N group, but the situation was alleviated in the HF group. B: The IL-4 level in the AS group was significantly higher than that in the N group (P<0.05), while the IL-4 level in the HF group was significantly reduced (P<0.01). C: The IgE level in the AS group was higher than that in the N group (P<0.05), while the IL-4 level in the HF group was significantly reduced (P<0.05).</p

Fecal microbial composition analysis and beta-diversity analysis.

A, B: analysis of the fecal microbial composition of the three groups on the family level and genus level; B, C: PCA analysis is used to explore the correlation of the composition of the microbiome on the family level and genus level of each group; C, D: ANOSIM analysis compares differences between groups and within groups (C:P <0.001, D: P<0.001).</p

Formula of regular feed.

(DOCX)</p

Analysis of short-chain fatty acid content in feces.

A-H: Quantitative analysis of short-chain fatty acids in mouse feces.</p

S1 File -

(RAR)</p

The Alpha diversity analysis of microbiome in feces.

The Alpha diversity analysis of microbiome in feces.</p