30 research outputs found
Forest plot for association of dual null genotype of GSTM1/GSTT1 and HCC risk.
<p>Forest plot for association of dual null genotype of GSTM1/GSTT1 and HCC risk.</p
Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis.
<p>Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis.</p
Meta-analysis of GSTM1 null genotype associated with HCC.
<p>Meta-analysis of GSTM1 null genotype associated with HCC.</p
The Association between <em>KCNQ1</em> Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis
<div><h3>Background</h3><p>KCNQ1 (potassium voltage-gated channel KQT-like sub-family, member 1) encodes a pore-forming subunit of a voltage-gated K<sup>+</sup> channel (KvLQT1) that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport in epithelial tissues. Recently, genome-wide association studies have identified KCNQ1 as a type 2 diabetes (T2D) susceptibility gene in populations of Asian descent. After that, a number of studies reported that the rs2237892 and rs2237895 polymorphism in KCNQ1 has been implicated in T2D risk. However, studies on the association between these polymorphism and T2D remain conflicting. To investigate this inconsistency, we performed this meta-analysis.</p> <h3>Methods</h3><p>Databases including Pubmed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression.</p> <h3>Results</h3><p>A total of 25 articles involving 70,577 T2D cases and 99,068 controls were included. Overall, the summary odds ratio of C allele for T2D was 1.32 (95% CI 1.26β1.38; P<10β5) and 1.24 (95% CI: 1.20β1.29; P<10β5) for KCNQ1 rs2237892 and rs2237895 polymorphisms, respectively. Significant results were also observed using co-dominant, dominant and recessive genetic models. After stratifying by ethnicity, sample size, and diagnostic criteria, significant associations were also obtained.</p> <h3>Conclusions</h3><p>This meta-analysis suggests that the rs2237892 and rs2237895 polymorphisms in KCNQ1 are associated with elevated type 2 diabetes susceptibility.</p> </div
Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma
<div><h3>Background</h3><p>A number of case-control studies were conducted to investigate the association of glutathione S-transferase (GST) genetic polymorphisms and hepatocellular carcinoma (HCC) risk. However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and HCC.</p> <h3>Methodology/Prinicpal Findings</h3><p>PubMed, EMBASE, ISI web of science and the CNKI databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression. Funnel plots and Eggerβs linear regression were used to test publication bias among the articles. A total of 34 studies including 4,463 cases and 6,857 controls were included in this meta-analysis. In a combined analysis, significantly increased HCC risks were found for null genotype of GSTM1 (ORβ=β1.29, 95% CI: 1.06β1.58; Pβ=β0.01) and GSTT1 (ORβ=β1.43, 95% CI: 1.22β1.68; P<10<sup>β5</sup>). Potential sources of heterogeneity were explored by subgroup analysis and meta-regression. Significant results were found in East Asians and Indians when stratified by ethnicity; whereas no significant associations were found among Caucasians and African populations. By pooling data from 12 studies that considered combinations of GSTT1 and GSTM1 null genotypes, a statistically significant increased risk for HCC (ORβ=β1.88, 95% CI: 1.41β2.50; P<10<sup>β4</sup>) was detected for individuals with combined deletion mutations in both genes compared with positive genotypes.</p> <h3>Conclusions/Significance</h3><p>This meta-analysis suggests that the GSTM1 and GSTT1 null genotype may slightly increase the risk of HCC and that interaction between unfavourable GSTs genotypes may exist.</p> </div
Meta-analysis of the <i>KCNQ1</i> rs2237892 polymorphism on type 2 diabetes risk.
<p>P(Z): Z test used to determine the significance of the overall OR.</p><p>P(Q): Cochranβs chi-square Q statistic test used to assess the heterogeneity in subgroups.</p
Meta-analysis of the association between KCNQ1 rs2237892 polymorphism and the risk for type 2 diabetes mellitus.
<p>Meta-analysis of the association between KCNQ1 rs2237892 polymorphism and the risk for type 2 diabetes mellitus.</p
Meta-analysis of the <i>KCNQ1</i> rs2237895 polymorphism on type 2 diabetes risk.
<p>NA: Not Available.</p><p>P(Z): Z test used to determine the significance of the overall OR.</p><p>P(Q): Cochranβs chi-square Q statistic test used to assess the heterogeneity in subgroups.</p
Characteristics of the studies included in the meta-analysis.
<p>NA: Not Available, WHO: World Health Organization, ADA: American Diabetes Association.</p