4 research outputs found
Direct Access to Nitrogen Bi-heteroarenes via Iridium-Catalyzed Hydrogen-Evolution Cross-Coupling Reaction
Through cooperative
actions of iridium catalyst and NaOTf additive
we report a new direct access to nitrogen bi-heteroarenes via hydrogen-evolution
cross-coupling of the β-site of indoles/pyrrole with the α-site
of <i>N</i>-heteroarenes. The reaction proceeds in an atom-
and redox-economic fashion together with the merits of an easily available
catalyst system, broad substrate scope, excellent functional tolerance,
and no need for external oxidants, offering a practical way to create
Ï€-conjugated systems
Iridium-Catalyzed Dehydrogenative α‑Functionalization of (Hetero)aryl-Fused Cyclic Secondary Amines with Indoles
Herein, by employing
dehydrogenation as a substrate-activating
strategy, a new iridium-catalyzed direct α-functionalization
of (hetero)Âaryl-fused cyclic secondary amines with indoles has been
demonstrated, which proceeds with merits that include high step- and
atom-efficiency, readily available feedstocks, a simple catalyst system,
good functional group tolerance, and operational simplicity
Aerobic Copper-Catalyzed Synthesis of Benzimidazoles from Diaryl- and Alkylamines via Tandem Triple C–H Aminations
Through
radical-induced tandem triple C–H aminations with
free amines as the aminating agents, we herein present a precedent
on aerobic copper-catalyzed synthesis of 5-diarylamino benzimidazoles,
a class of optoelectronic device analogues by combining two molecules
of diarylamines and one molecule of alkylamine in one single operation.
The developed chemistry proceeds with the merits of a natural abundant
copper/O<sub>2</sub> catalyst system, readily available feedstocks,
broad substrate scope, good functional group tolerance, exclusive
regio- and chemoselectivity, high step and atom efficiency, which
offers an important basis for further construction of functional products
that are inaccessible or difficult to prepare with the existing methods
by employing catalytic tandem C–H amination strategy
In Situ Activation of Azaarenes and Terminal Alkynes to Construct Bridged Polycyclic Compounds Containing Isoquinolinones
A copper-catalyzed
[4+2] cyclization reaction of isoquinolines
and alkynes is developed for the one-step construction of isoquinolinone
derivatives with multisubstituted bridging rings. The unique feature
of this three-component tandem cyclization reaction is the functionalization
of the C1, N2, C3, and C4 positions of 3-haloisoquinolines via the
construction of new C–N, CO, and C–C bonds.
This dearomatization strategy for the synthesis of structurally complex
isoquinolinone-bridged cyclic compounds offers good chemoselectivity,
broad functional group compatibility, greenness, and high step economy