4 research outputs found

    Direct Access to Nitrogen Bi-heteroarenes via Iridium-Catalyzed Hydrogen-Evolution Cross-Coupling Reaction

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    Through cooperative actions of iridium catalyst and NaOTf additive we report a new direct access to nitrogen bi-heteroarenes via hydrogen-evolution cross-coupling of the β-site of indoles/pyrrole with the α-site of <i>N</i>-heteroarenes. The reaction proceeds in an atom- and redox-economic fashion together with the merits of an easily available catalyst system, broad substrate scope, excellent functional tolerance, and no need for external oxidants, offering a practical way to create π-conjugated systems

    Iridium-Catalyzed Dehydrogenative α‑Functionalization of (Hetero)aryl-Fused Cyclic Secondary Amines with Indoles

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    Herein, by employing dehydrogenation as a substrate-activating strategy, a new iridium-catalyzed direct α-functionalization of (hetero)­aryl-fused cyclic secondary amines with indoles has been demonstrated, which proceeds with merits that include high step- and atom-efficiency, readily available feedstocks, a simple catalyst system, good functional group tolerance, and operational simplicity

    Aerobic Copper-Catalyzed Synthesis of Benzimidazoles from Diaryl- and Alkylamines via Tandem Triple C–H Aminations

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    Through radical-induced tandem triple C–H aminations with free amines as the aminating agents, we herein present a precedent on aerobic copper-catalyzed synthesis of 5-diarylamino benzimidazoles, a class of optoelectronic device analogues by combining two molecules of diarylamines and one molecule of alkylamine in one single operation. The developed chemistry proceeds with the merits of a natural abundant copper/O<sub>2</sub> catalyst system, readily available feedstocks, broad substrate scope, good functional group tolerance, exclusive regio- and chemoselectivity, high step and atom efficiency, which offers an important basis for further construction of functional products that are inaccessible or difficult to prepare with the existing methods by employing catalytic tandem C–H amination strategy

    In Situ Activation of Azaarenes and Terminal Alkynes to Construct Bridged Polycyclic Compounds Containing Isoquinolinones

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    A copper-catalyzed [4+2] cyclization reaction of isoquinolines and alkynes is developed for the one-step construction of isoquinolinone derivatives with multisubstituted bridging rings. The unique feature of this three-component tandem cyclization reaction is the functionalization of the C1, N2, C3, and C4 positions of 3-haloisoquinolines via the construction of new C–N, CO, and C–C bonds. This dearomatization strategy for the synthesis of structurally complex isoquinolinone-bridged cyclic compounds offers good chemoselectivity, broad functional group compatibility, greenness, and high step economy
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