DataSheet1_Extracting geological and alteration information and predicting antimony ore based on multisource remote sensing data in Huangyangling, Xinjiang.docx

Introduction: China has the world’s largest amount of antimony resources and plays a vital role in the global antimony industry. The Huangyangling area in Xinjiang belongs to the Lazhulong-Huangyangling antimony mineralization belt; this area is rich in antimony ore resources, with potential for discovery of additional ore. This high-elevation mountainous area is located in the northwestern region of the northern Tibetan Plateau, with a harsh natural environment and poor transportation access; thus, the use of traditional geological exploration methods is limited, and remote sensing technology provides unique advantages.Methods: Using Landsat 8 OLI and Gaofen-6 (GF-6) data, we extracted stratigraphic, lithologic and fault information from the study area through information enhancement processing of the images. Based on Landsat 8 OLI, Sentinel-2 and ASTER images and the use of remote sensing image preprocessing and interference information masking, the spectral characteristics of limonite, as well as hydroxyl, carbonate, and silicified alteration minerals were utilized; the characteristics included reflection or absorption in specific spectral bands. The spectral characteristics were then combined with principal component analysis (PCA) and the band ratio method to extract the alteration information for the study area.Results: The stratigraphy and boundaries between stratigraphic and lithologic units extracted in this study were defined, and numerous small faults were identified based on a comparison with 1:250,000 geologic maps. And the overall distribution trends of the indicators of alteration extracted in this study were located along fault zones; additionally, the hydroxyl and carbonate alteration anomalies matched well with known deposits (occurrences). Thus, the alteration information is a good indication of antimony ore bodies. Based on the geological interpretation, alteration information extraction and geochemical exploration data, four prospecting areas were identified.Discussion: The method of extracting geological and hydrothermal alteration information by remote sensing has practical significance because it provides the possibility for geological work and mineral exploration in difficult high-elevation environments.</p

<i>Let-7b</i> repletion selectively chemosensitizes <i>KRAS</i> mutant tumor cells.

<p>NSCLC cells A549 (<i>KRAS</i> mutant) and NIH-H1975 (<i>KRAS</i> wild-type), PDAC cells Panc-1 (<i>KRAS</i> mutant) and BxPC-3 (<i>KRAS</i> wild-type) were transfected with <i>let-7b</i> mimic (50 nM) or the scramble control (SCR, 50 nM) for 6 hours. The cells were then treated with paclitaxel (PTX, 0.1–50 nM) or gemcitabine (GEM, 5–150 nM or 5–150 μM) for 48 hours. Cell viability was assessed by the crystal violet assay. Each experiment was carried out at least 3 times. Data represent the mean ±SEM.</p

<i>Let-7b</i> selectively downregulates mutant KRAS expression.

<p>The endogenous levels of <i>let-7b</i> (A), KRAS mRNA (B) and KRAS protein (C) in NIH-H1975, A549, BxPC-3 and Panc-1 cells. The expression of <i>let-7b</i> (D), KRAS protein (E) and KRAS mRNA (F) in the cells transfected with <i>let-7b</i> mimic alone or in combination with PTX or GEM. Each experiment was carried out at least 3 times. Data represent the mean ±SEM. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01.</p

<i>Let-7b</i>/cytotoxin combination reduces migration and invasion of <i>KRAS</i> mutant tumor cells.

<p>A, the effect of <i>let-7b</i> mimic, paclitaxel or gemcitabine on cell migration was evaluated in A549 and Panc-1 cells at 0, 12 and 24 hours following the scratch wound (images, left panel). The area of wound healing was quantified by ImageJ (right panel). B, the matrigel invasion assay was conducted to evaluate the effect of <i>let-7b</i> mimic, paclitaxel or gemcitabine on the invasiveness of A549 and Panc-1 cells. Images were acquired using an inverted microscope at × 40 magnification. C, Protein levels of HMGA2, Snail 1, E-cadherin and vimentin in A549 and Panc-1 cells were assessed by Western blotting. Each experiment was carried out at least 3 times. Data represent the mean ± SEM. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01.</p

<i>Let-7b</i>/cytotoxin combination blocks cell cycle progression and inhibits colony formation of <i>KRAS</i> mutant tumor cells.

<p>The effect of <i>let-7b</i> mimic, paclitaxel or gemcitabine on cell cycle progression in A549 (A) and Panc-1 cells (B) was evaluated by flow cytometry. The effect of <i>let-7b</i> mimic, paclitaxel or gemcitabine on colony formation of A549 (C) and Panc-1 cells (D) was visualized by crystal violet staining. Each experiment was carried out at least 3 times. Data represent the mean ± SEM. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01.</p

<i>Let-7b</i>/cytotoxin combination blocks mutant KRAS signaling and promotes apoptosis.

<p>The effect of <i>let-7b</i> mimic, paclitaxel or gemcitabine on the phosphorylation of MEK, ERK1/2, and AKT in <i>KRAS</i> mutant A549 (A) and Panc-1 cells (B). The apoptotic cells were detected by flow cytometry using Annexin V-FITC and PI dual staining, and the apoptotic protein markers caspase-3, PARP and BCL-2 were assessed by Western blotting in A549 (C) and Panc-1 cells (D). Each experiment was carried out at least 3 times.</p

sj-docx-1-spp-10.1177_19485506241234093 – Supplemental material for Spillover Between Daily Marital Interactions and Parenting Practices: Sensory Processing Sensitivity as Moderators

Supplemental material, sj-docx-1-spp-10.1177_19485506241234093 for Spillover Between Daily Marital Interactions and Parenting Practices: Sensory Processing Sensitivity as Moderators by Ni Yan, Xin Dai, Xiaoqin Ding and Shuang Bi in Social Psychological and Personality Science</p

Design and Control of Dividing-Wall Column for the Synthesis of <i>n</i>‑Propyl Propionate by Reactive Distillation

In this work, a reactive dividing-wall column (R-DWC) for the synthesis of <i>n</i>-propyl propionate was investigated by demonstrating its design and control. Sensitivity analysis of whether the vapor split ratio (α_v) can maintain the product purities was studied before the minimum TAC was established. The results show that the R-DWC can save 12.4% of the energy consumption and 16.4% of the minimum total annual cost (TAC) compared with the two-column design. After that, two control structures for the R-DWC as a three-column model were considered. The improved control structure can solve the problem of disturbances and maintain the product purities close to the set points with small deviations and short settling times

Catalytic and Atom-Economic Intermolecular Amidoselenenylation of Alkenes

A method for the simple, efficient, and atom-economic amidoselenenylation of simple alkenes under mild conditions using TiCl₄ as a catalyst and <i>N</i>-(phenylseleno)­phthalimide as both a nitrogen and selenium source was developed. A broad range of olefins can be applied to afford vicinal amidoselenides in good yield and with high regioselectivity and diastereoselectivity

Catalytic Selenium-Promoted Intermolecular Friedel–Crafts Alkylation with Simple Alkenes

A method for conducting selenium-promoted intermolecular Friedel–Crafts (F–C) alkylation reactions has been developed with simple alkenes using trimethylsilyl trifluoromethanesulfonate as a catalyst and <i>N</i>-phenylselenophthalimide as an efficient selenium source. Electron-rich arenes smoothly underwent F–C alkylation with a variety of alkenes to afford alkylated products in good yield and with high regioselectivity and diastereoselectivity. The regioselectivity and stereoselectivity of arenes and alkenes as well as a preliminary mechanism of the F–C alkylation reaction are discussed