Some Statistical Issues in the LHCb Experiment

This paper describes statistical issues that are of particular importance and interest to the LHCb experiment in probing new physics beyond the Standard Model through study of CP violation and rare phenomena in B decays. A wish list for statistical methods and tools that will help LHCb to exploit its full physics potential is given at the end

CP violation in heavy-flavour decays

The CKM matrix is the only source of CP violation in the Standard Model.Heavy-flavour decays provide an ideal laboratory to test the CKM mechanism. Some recent highlights in CP violation in heavy-flavour decays from the LHCb and Belle II experiments are presented, including updated measurements of the CKM angles $\beta$, $\gamma$ and $\phi_s$, and new results in CP violation in charm decays.Comment: Proceedings for the 31st International Symposium on Lepton Photon Interactions at High Energie

Information Extraction from Research Papers based on Conditional Random Field Model

With the increasing use of CiteSeer academic search engines, the accuracy of such systems has become more and more important. The paper adopts the improved particle swarm optimization algorithm for training conditional random field model and applies it into the research papers’ title and citation retrieval. The improved particl swarm optimization algorithm  brings the particle swarm aggregation to prevent particle swarm from being plunged into local convergence too early, and uses the linear inertia factor and learning factor to update particle rate. It can control algorithm in infinite iteration by the iteration between particle relative position change rate. The results of which using the standard research papers’ heads and references to evaluate the trained conditional random field model shows that compared with traditionally conditional random field model and Hidden Markov Model, the conditional random field model ,optimized and trained by improved particle swarm, has been better ameliorated in the aspect of F1 mean error and word error rate. DOI: http://dx.doi.org/10.11591/telkomnika.v11i3.218

Activation of hedgehog signaling is not a frequent event in ovarian cancers

The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression by in-situ hybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors