Characterization of Cell Glycocalyx with Mass Spectrometry Methods.

The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function. Crucial intercellular processes, such as signal transduction and immune protection, are mediated by cell surface glycosylation, which is comprised of large biomolecules, including glycoproteins and glycosphingolipids. Because perturbations in glycosylation could result in dysfunction of cells and are related to diseases, the analysis of surface glycosylation is critical for understanding pathogenic mechanisms and can further lead to biomarker discovery. Different mass spectrometry-based techniques have been developed for glycan analysis, ranging from highly specific, targeted approaches to more comprehensive profiling studies. In this review, we summarized the work conducted for extensive analysis of cell membrane glycosylation, particularly those employing liquid chromatography with mass spectrometry (LC-MS) in combination with various sample preparation techniques

The long-term optical behavior of MRK421

All data available in B band for the BL Lac object MRK421 from 22 publications are used to construct a historical light curve, dating back to 1900. It is found that the light curve is very complicated and consists of a set of outbursts with very large duration. The brightness of MRK421 varies from 11.6 magnitude to more than 16 magnitude. Analyses with Jurkevich method of computing period of cyclic phenomena reveal in the light curve two kinds of behaviors. The first one is non-periodic with rapid, violent variations in intensity on time scales of hours to days. The second one is periodic with a possible period of $23.1\pm 1.1$ years. Another possible period of $15.3\pm 0.7$ years is not very significant. We have tested the robustness of the Jurkevich method. The period of about one year found in the light curves of MRK421 and of other objects is a spurious period due to the method and the observing window. We try to explain the period of $23.1 \pm1.1$ years under the thermal instability of a slim accretion disk around a massive black hole of mass of $2 *10^6 M_\odot$.Comment: Tex, 14 pages, 5 Postscript figures. Accepted for publication in A&A Supplement Serie

Nonperturbative signatures in pair production for general elliptic polarization fields

The momentum signatures in nonperturbative multiphoton pair production for general elliptic polarization electric fields are investigated by employing the real-time Dirac-Heisenberg-Wigner formalism. For a linearly polarized electric field we find that the positions of the nodes in momenta spectra of created pairs depend only on the electric field frequency. The polarization of external fields could not only change the node structures or even make the nodes disappear but also change the thresholds of pair production. The momentum signatures associated to the node positions in which the even-number-photon pair creation process is forbid could be used to distinguish the orbital angular momentum of created pairs on the momenta spectra. These distinguishable momentum signatures could be relevant for providing the output information of created particles and also the input information of ultrashort laser pulses.Comment: 8 pages, 4 figures, submitted to Europhysics Letter

Money, moral transgressions, and blame

Two experiments tested participants' attributions for others' immoral behaviors when conducted for more versus less money. We hypothesized and found that observers would blame wrongdoers more when seeing a transgression enacted for little rather than a lot of money, and that this would be evident in observers' hand-washing behavior. Experiment 1 used a cognitive dissonance paradigm. Participants (N = 160) observed a confederate lie in exchange for either a relatively large or a small monetary payment. Participants blamed the liar more in the small (versus large) money condition. Participants (N = 184) in Experiment 2 saw images of someone knocking over another to obtain a small, medium, or large monetary sum. In the small (versus large) money condition, participants blamed the perpetrator (money) more. Hence, participants assigned less blame to moral wrong-doers, if the latter enacted their deed to obtain relatively large sums of money. Small amounts of money accentuate the immorality of others' transgressions