Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B

<p>Lauroside B, a megastigmane sesquiterpene glycoside isolated from <i>L. nobilis</i> leaves, has the potential effect of inducing apoptosis of several highly aggressive malignant melanoma cell lines. To promote the potential development of lauroside B as a possible chemotherapeutic agent to treat human melanoma, the structure and activity relationship studies should be of great importance. In this work, two diastereomers of lauroside B were synthesized through a straightforward approach and the details of the key steps were investigated, which would provide useful information for developing an efficient method toward the synthesis of lauroside B and its structural analogs.</p

Additional file 1 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

Additional file 1. RoB-2 evaluation

Additional file 2 of Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease

Additional file 2. Publication bias