sj-docx-1-rse-10.1177_07419325221147699 – Supplemental material for Improving Social Interactions for Young Children on the Autism Spectrum Through Parent-Mediated LEGO Play Activities

Supplemental material, sj-docx-1-rse-10.1177_07419325221147699 for Improving Social Interactions for Young Children on the Autism Spectrum Through Parent-Mediated LEGO Play Activities by Gabrielle T. Lee, PhD, Yitong Jiang, MA and Xiaoyi Hu, PhD in Remedial and Special Education</p

sj-docx-2-rse-10.1177_07419325221147699 – Supplemental material for Improving Social Interactions for Young Children on the Autism Spectrum Through Parent-Mediated LEGO Play Activities

Supplemental material, sj-docx-2-rse-10.1177_07419325221147699 for Improving Social Interactions for Young Children on the Autism Spectrum Through Parent-Mediated LEGO Play Activities by Gabrielle T. Lee, PhD, Yitong Jiang, MA and Xiaoyi Hu, PhD in Remedial and Special Education</p

Theoretical Investigations on the Hydroxyl-Initialized Oxidation of Hexafluoro-2-butyne in the Presence of Oxygen

Hexafluoro-2-butyne (C4F6) is a potential eco-friendly alternative gas in plasma, refrigerants, and electrical insulation applications. Mechanisms for the reactions of C4F6 with OH/O2 have been revealed in detail using various theoretical methods including ROCBS-Q, RCCSD­(T), multireference RS2C, and extrapolations to the complete basis-set limit with Aug-cc-pVnZ (n = T, Q, 5) basis sets. Rate coefficients and product branching ratios were predicted for a wide range of temperatures and pressures using the solution of master equations. The vibrationally adiabatic ground-state barrier for the initial C4F6 + OH association was best estimated to be 1.53–2.26 kcal/mol. Energetically preferable decomposition paths for the conformation-dependent C4F6OH adducts include six-center HF elimination, four-center proton migration, and C–C bond cleavage, but the collisional deactivation is dominant under ambient conditions. The subsequent oxidation of C4F6OH by O2 bifurcates in two orientations and proceeds without any well-defined barrier followed by the successive isomerization/elimination steps, forming perfluorobiacetyl to regenerate OH radicals or trifluoroacetic acid with trifluoroacetyl radicals. The OH-recycling path accounts for a branching ratio of 70% under ambient conditions. Theoretical rate coefficients are in good agreement with the available experimental results. The effect of fluorination on the reactivity of alkynes toward OH/O2 is discussed

Fumarranol, a Rearranged Fumagillin Analogue That Inhibits Angiogenesis in Vivo

The fumagillin family of natural products inhibits angiogenesis through the irreversible inhibition of the type 2 methionine aminopeptidase (MetAP2). Herein is reported a novel fumagillin analogue named fumarranol. It is shown that, like fumagillin, fumarranol selectively inhibits MetAP2 and endothelial cell proliferation. It is also active in a mouse model of angiogenesis in vivo. Unlike TNP-470, fumarranol does not covalently bind to MetAP2. Fumarranol may serve as a lead for a new class of angiogenesis inhibitors

Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement

As a layer of soft fibrous tissue, the periodontal ligament (PDL) protects against mechanical shock when transmitting mastication force from tooth to its surrounding alveolar bone. Currently, no quantitative method is available to estimate the shock resistance ability of the PDL. To solve this problem, in the present study we developed a finite element (FE) model of the tooth-PDL-bone complex and analyzed the energy storage and dissipation during the mastication movements. Displacement and Mises stress of tooth-PDL-bone complex show that the PDL is able to protect the alveolar bone from mechanical shock by shielding the transfer of deformation and stress. During mastication, the energy of the PDL is stored up to ∼161.5 J/mm3 at the period of loading and dissipated about one-tenth of the stored energy when unloading. The energy storage is displacement-dependent but time-independent because of the hyperelasticity of PDL. However, the energy dissipation is time- and displacement-dependent because of the viscoelasticity of PDL. The present study helps to understand the periodontal potential and the origin of dental diseases such as tooth concussion and occlusal trauma from the view of energy conversion

OSW Saponins: Facile Synthesis toward a New Type of Structures with Potent Antitumor Activities

OSW saponins, featuring a 16β,17α-dihydroxycholest-22-one aglycon and an acylated β-d-xylopyranosyl-(1→3)-α-l-arabinopyranosyl residue attached to the 16-hydroxyl group, have recently been discovered from a group of lily plants, which show potent antitumor activities with a novel mechanism of action. This paper describes an aldol approach to the stereoselective construction of the 16α,17α-dihydroxycholest-22-one structure from 16α-hydroxy-5-androsten-17-ones and propionates. Elaboration of the aldol adducts toward OSW-1, involving installation of the isoamyl ketone side chain, inversion of the 16-hydroxyl configuration, and selective protection of the C22-oxy function, has been explored and accomplished. In particular, the present route was found convenient for the synthesis of OSW saponin analogues with a C22-ester side chain. Thus, the 23-oxa-analogue of OSW-1 (40) was prepared starting from the industrial dehydroisoandrosterone (1) in a linear eight-step sequence and in 26% overall yield. Analogues with a variety of modified side chains were prepared, via aldol condensation with propionates of varying length, thiopropionate, and acetate (for preparation of 68−75) or via aminolysis of the 22,16-lactone 26 (for preparation of the 23-N-analogues). Cross metathesis (CM) reaction was also found feasible for modification at the final stage from C22-allyl ester 70. Valuable structure−activity relationships (SAR), together with the practical synthetic approach, have thus been provided to set a new stage for further studies on this new type of antitumor structures

OSW Saponins: Facile Synthesis toward a New Type of Structures with Potent Antitumor Activities

OSW saponins, featuring a 16β,17α-dihydroxycholest-22-one aglycon and an acylated β-d-xylopyranosyl-(1→3)-α-l-arabinopyranosyl residue attached to the 16-hydroxyl group, have recently been discovered from a group of lily plants, which show potent antitumor activities with a novel mechanism of action. This paper describes an aldol approach to the stereoselective construction of the 16α,17α-dihydroxycholest-22-one structure from 16α-hydroxy-5-androsten-17-ones and propionates. Elaboration of the aldol adducts toward OSW-1, involving installation of the isoamyl ketone side chain, inversion of the 16-hydroxyl configuration, and selective protection of the C22-oxy function, has been explored and accomplished. In particular, the present route was found convenient for the synthesis of OSW saponin analogues with a C22-ester side chain. Thus, the 23-oxa-analogue of OSW-1 (40) was prepared starting from the industrial dehydroisoandrosterone (1) in a linear eight-step sequence and in 26% overall yield. Analogues with a variety of modified side chains were prepared, via aldol condensation with propionates of varying length, thiopropionate, and acetate (for preparation of 68−75) or via aminolysis of the 22,16-lactone 26 (for preparation of the 23-N-analogues). Cross metathesis (CM) reaction was also found feasible for modification at the final stage from C22-allyl ester 70. Valuable structure−activity relationships (SAR), together with the practical synthetic approach, have thus been provided to set a new stage for further studies on this new type of antitumor structures

Arranging play activities with missing items to increase object-substitution symbolic play in children with autism spectrum disorder

Purpose: Many children with autism spectrum disorder do not have symbolic play skills. The purpose of this study was to evaluate the effects of a training procedure on the acquisition, maintenance, and generalization of object-substitution symbolic play in children with autism spectrum disorder. Methods: A single-case experimental design (multiple-probe across four behaviors) was used. One girl (5 years) and two boys (4–5 years) participated in this study. The training procedure involved withdrawing necessary items in play activities, supplying multiple substitutes, and providing hierarchical assistive prompts. Each child’s symbolic play responses across baseline, intervention, and follow-up conditions were recorded and graphed. Data analysis involved visual inspection of graphs. Results: The results indicated that the procedure effectively increased and maintained object-substitution symbolic play. Generalization to untaught play activities occurred in all children, and symbolic play increased in the free play setting for one child. Conclusions: Arranging play activities with missing items increased opportunities for children to engage in symbolic play. The training procedure can be used in clinical and educational settings as an initial step to establish and improve complex play behavior in children with autism spectrum disorder who lack such skills.IMPLICATIONS FOR REHABILITATIONMany children with autism spectrum disorder have inappropriate play behaviors and do not demonstrate symbolic play.Arranging play activities with missing items and systematic assistive prompts effectively increased object-substitution symbolic play.Generalization of symbolic play to untrained play activities occurred after the intervention. Many children with autism spectrum disorder have inappropriate play behaviors and do not demonstrate symbolic play. Arranging play activities with missing items and systematic assistive prompts effectively increased object-substitution symbolic play. Generalization of symbolic play to untrained play activities occurred after the intervention.</p

OSW Saponins: Facile Synthesis toward a New Type of Structures with Potent Antitumor Activities

OSW saponins, featuring a 16β,17α-dihydroxycholest-22-one aglycon and an acylated β-d-xylopyranosyl-(1→3)-α-l-arabinopyranosyl residue attached to the 16-hydroxyl group, have recently been discovered from a group of lily plants, which show potent antitumor activities with a novel mechanism of action. This paper describes an aldol approach to the stereoselective construction of the 16α,17α-dihydroxycholest-22-one structure from 16α-hydroxy-5-androsten-17-ones and propionates. Elaboration of the aldol adducts toward OSW-1, involving installation of the isoamyl ketone side chain, inversion of the 16-hydroxyl configuration, and selective protection of the C22-oxy function, has been explored and accomplished. In particular, the present route was found convenient for the synthesis of OSW saponin analogues with a C22-ester side chain. Thus, the 23-oxa-analogue of OSW-1 (40) was prepared starting from the industrial dehydroisoandrosterone (1) in a linear eight-step sequence and in 26% overall yield. Analogues with a variety of modified side chains were prepared, via aldol condensation with propionates of varying length, thiopropionate, and acetate (for preparation of 68−75) or via aminolysis of the 22,16-lactone 26 (for preparation of the 23-N-analogues). Cross metathesis (CM) reaction was also found feasible for modification at the final stage from C22-allyl ester 70. Valuable structure−activity relationships (SAR), together with the practical synthetic approach, have thus been provided to set a new stage for further studies on this new type of antitumor structures

Data_Sheet_2_Follow-Ups on Persistent Symptoms and Pulmonary Function Among Post-Acute COVID-19 Patients: A Systematic Review and Meta-Analysis.docx

Objective: As the number of recovering COVID-19 patients increases worldwide, the persistence of symptoms and signs through the post-acute phase indicates an urgent need for prolonged follow-up care. To explore existing data about post-acute COVID-19 syndrome, this meta-analysis assesses the prevalence of persistent manifestations in multiple systems and abnormalities in lung function, as well as their related risks in patients with various severities.Methods: Articles about discharged COVID-19 patients (published from January 1, 2020 to February 23, 2021) were obtained by searching four databases. Cohort studies with follow-up periods >1 month post-discharge or >2 months post-admission were included.Results: A total of 4,478 COVID-19 patients from 16 cohort studies were included in this meta-analysis. Fatigue or weakness (47%) were the most prevalent physical effects of post-acute COVID-19 syndrome, while psychosocial (28%) symptoms were the most common manifestations among several systems. Abnormalities in lung function of recovering patients, i.e., DLCO Conclusions: Our research indicates that patients recovering from COVID-19 manifest long-term, multi-system symptoms, and the adverse effects on psychosocial health and lung functions were the most extensive and persistent. These findings together may facilitate much needed in-depth study of clinical treatments for long-term, post-acute phase symptoms that affect a great number of recovering COVID-19 patients.</p