3 research outputs found
Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives
A practical
and unified strategy has been described for the preparation
of mono- and difluoromethylated phenanthridine derivatives using a
visible-light-promoted alkylation and decarboxylation sequence from
biphenyl isocyanides with ethyl bromofluoroacetate (EBFA) or ethyl
bromodifluoroacetate (EBDFA). These reactions could be carried out
at room temperature in good to excellent chemical yields. Both stepwise
and one-pot procedures have been developed, which makes this strategy
more attractive
Halogen-Bond-Promoted Double Radical Isocyanide Insertion under Visible-Light Irradiation: Synthesis of 2‑Fluoroalkylated Quinoxalines
A halogen-bond-promoted
double radical isocyanide insertion with
perfluoroalkyl iodides is reported. With perfluoroalkyl iodides as
halogen-bond donors and organic bases as halogen-bond acceptors, fluoroalkyl
radicals can be generated by a visible-light-induced single electron
transfer (SET) process. The fluoroalkyl radicals are trapped by <i>o</i>-diisocyanoarenes to give quinoxaline derivatives. This
mechanistically novel strategy allows the construction of 2-fluoroalkylated
3-iodoquinoxalines in high yields under visible-light irradiation
at room temperature
Halogen-Bond-Promoted Double Radical Isocyanide Insertion under Visible-Light Irradiation: Synthesis of 2‑Fluoroalkylated Quinoxalines
A halogen-bond-promoted
double radical isocyanide insertion with
perfluoroalkyl iodides is reported. With perfluoroalkyl iodides as
halogen-bond donors and organic bases as halogen-bond acceptors, fluoroalkyl
radicals can be generated by a visible-light-induced single electron
transfer (SET) process. The fluoroalkyl radicals are trapped by <i>o</i>-diisocyanoarenes to give quinoxaline derivatives. This
mechanistically novel strategy allows the construction of 2-fluoroalkylated
3-iodoquinoxalines in high yields under visible-light irradiation
at room temperature