Construction of Multifunctional Luminescent Lanthanide MOFs for Luminescent Sensing of Temperature, Trifluoroacetic Acid Vapor and Explosives

Metal–organic frameworks (MOFs) with multifunctional and tunable optical properties have unique advantages in the field of sensing, and the structure and properties of MOFs are significantly influenced by the ligands. In this study, a Y-type tricarboxylic acid ligand containing amide bonds was synthesized through functional guidance, and three isomorphic and heterogeneous three-dimensional MOFs (Eu-MOF, Tb-MOF, and Gd-MOF) were obtained by solvothermal reaction. Further studies revealed that both the Tb-MOF and Eu-MOF could selectively detect picric acid (PA). The luminescence quenching of the two MOFs by PA was attributed to competing absorption and photoelectron energy transfer mechanisms. In addition, due to the energy transfer between Tb and Rhodamine B, Rhodamine B was encapsulated into Tb-MOF. The obtained material exhibited a linear relationship between the temperature parameters I544/I584 and temperature within the range of 280–400 K, the correlation coefficient (R2) reached an impressive value of 0.999, and the absolute sensitivity of the sample used for temperature sensing was 1.534% K–1. What is more, the material exhibited a good response to trifluoroacetic acid vapor, which suggests the potential of the material for temperature sensing and detection of trifluoroacetic acid vapor. The designed and investigated strategy can also serve as a reference for further research on excellent multifunctional sensors

Bosutinib Laden Three-Dimensional Printed Zein Scaffolds Promote Osteogenesis

Bone defect repair remains a challenge to be addressed in clinical practice, and existing bone grafting methods still have disadvantages and limitations. Drugs or cytokines laden into bioactive scaffolds to promote bone regeneration is a promising strategy to deal with the problem; thus, it is meaningful to develop drugs and scaffolds with osteogenic abilities. Drug repurposing is an admirable method to find unknown usages of old drugs for enhancing osteogenic differentiation. In this study, by screening an approved drug library consisting of 2040 compounds, bosutinib, a tyrosine kinase inhibitor, was identified to promote osteogenic differentiation in vitro. The observed effect was further confirmed using polymerase chain reaction (PCR), western blot, Alizarin Red staining, and alkaline phosphatase (ALP) activity staining. Subsequently, transcriptome sequencing was performed to elucidate the osteogenesis mechanism of bosutinib, and a potential target gene, Storkhead box 1 (STOX1), which was not reported to be associated with osteogenesis, was found. By a gene knockdown strategy, we provided preliminary evidence that bosutinib can promote osteogenic differentiation by mediating STOX1. Furthermore, in order to maximize the local effects of drug and minimize its side effects, a bosutinib laden three-dimensional (3D)-printed zein scaffold was constructed and characterized, and its ability of promoting osteogenesis was evaluated in vivo. Micro-CT analysis and histological staining demonstrated that the scaffold effectively promoted bone regeneration. All in all, our study provides a therapeutic option for the treatment of bone defects

Data_Sheet_1_Phenomenological characteristics of autobiographical future thinking in nurses with burnout: a case-control study.doc

ObjectiveNurses constitute the largest group of healthcare workers worldwide, and job burnout is very common among them. This study aims to explore abnormal future thinking in nurses with burnout. Additionally, the study investigates whether these manifestations worsen as burnout progresses.MethodsThe study was conducted in inpatient ward nurses at a tertiary hospital in Hangzhou, China. In the first phase, two group of nurses were recruited: nurses with burnout (N = 70) and nurses without burnout (N = 70). In the second phase, three groups were recruited according to the burnout levels: mild burnout (N = 43), moderate burnout (N = 42) and severe burnout (N = 43). Data on job burnout were obtained using the Chinese Maslach Burnout Inventory. The Sentence Completion for Events in the Future Test (SCEFT) was employed to measure the content of future thinking, which was evaluated by two raters in terms of the specificity, emotional valence, and concrete content of the imagined future events. The proportions of specific types of events among all the produced events were calculated.ResultsThe results revealed that nurses with burnout, compared to nurses without burnout, imagined fewer specific future events, positive events, and events related to relationships and achievement. They also had more omissions. As the level of burnout increased, their impairment in future thinking worsened. Furthermore, the results also revealed that the scores of emotional exhaustion, depersonalization, and personal accomplishment had significant correlations with the proportions of positive events and events related to relationships and achievement/mastery in nurses’ future thinking content.ConclusionThe future thinking ability of nurses with burnout was impaired, and this impairment worsened as the symptoms of burnout progressed. The findings of the present study have important implications for nurse caring and advocate effective interventions targeting positive future thinking to mitigate nurses’ burnout.</p

Kinetic parameters of sorafenib calculated by M2 formation in pooled NHLMs, THLMs and CHLMs.

<p>Kinetic parameters of sorafenib calculated by M2 formation in pooled NHLMs, THLMs and CHLMs.</p

Pooled concentrations of Cd in different areas of China.

Pooled concentrations of Cd in different areas of China.</p

Meta-analysis of Pb concentrations in rice.

Meta-analysis of Pb concentrations in rice.</p

Sorafenib metabolism by CYP3A4 (A–E) and CYP3A4 protein expression (F) in pooled NHLMs, THLMs and CHLMs.

<p>The formation rate of M2 expressed as pmol/mg/min (mean ± SD), other metabolites rates (M1, M3, M4 and M5) expressed as peak area ratio (mean ± SD). All the experiments were carried out in triplicate. One-way ANOVA, with or without Tukey–Kramer multiple comparison (post-hoc) tests, was used for data analysis. “*” denotes statistical significance (<i>P</i><0.05); “**” denotes statistical significance (<i>P</i><0.01), “***” denotes statistical significance (<i>P</i><0.001).</p

Flow diagram of study inclusion in the meta-analysis.

Flow diagram of study inclusion in the meta-analysis.</p

Pooled concentrations of Pb in different areas of China.

Pooled concentrations of Pb in different areas of China.</p

THQ and total THQ of Pb and Cd due to rice consumption.

THQ and total THQ of Pb and Cd due to rice consumption.</p