Supplementary document for Low-noise mode-locking in GHz repetition rate Tm3+-doped fiber laser - 6705798.pdf

Details about the numerical simulation and experimental result

Nature-Inspired Surface Engineering for Efficient Atmospheric Water Harvesting

Atmospheric water harvesting is a sustainable solution to global water shortage, which requires high efficiency, high durability, low cost, and environmentally friendly water collectors. In this paper, we report a novel water collector design based on a nature-inspired hybrid superhydrophilic/superhydrophobic aluminum surface. The surface is fabricated by combining laser and chemical treatments. We achieve a 163° contrast in contact angles between the superhydrophilic pattern and the superhydrophobic background. Such a unique superhydrophilic/superhydrophobic combination presents a self-pumped mechanism, providing the hybrid collector with highly efficient water harvesting performance. Based on simulations and experimental measurements, the water harvesting rate of the repeating units of the pattern was optimized, and the corresponding hybrid collector achieves a water harvesting rate of 0.85 kg m–2 h–1. Additionally, our hybrid collector also exhibits good stability, flexibility, as well as thermal conductivity and hence shows great potential for practical application

Practical GHz single-cavity all-fiber dual-comb laser for high-speed spectroscopy

Dual-comb spectroscopy (DCS) with few-GHz tooth spacing that provides the optimal trade-off between spectral resolution and refresh rate is a powerful tool for measuring and analyzing rapidly evolving transient events. Despite such an exciting opportunity, existing technologies compromise either the spectral resolution or refresh rate, leaving few-GHz DCS with robust design largely unmet for frontier applications. In this work, we demonstrate a novel GHz DCS by exploring the multimode interference-mediated spectral filtering effect in an all-fiber ultrashort cavity configuration. The GHz single-cavity all-fiber dual-comb source is seeded by a dual-wavelength mode-locked fiber laser operating at fundamental repetition rates of about 1.0 GHz differing by 148 kHz, which has an excellent stability in the free-running state that the Allan deviation is only 101.7 mHz for an average time of 1 second. Thanks to the large repetition rate difference between the asynchronous dichromatic pulse trains, the GHz DCS enables a refresh time as short as 6.75 us, making it promising for studying nonrepeatable transient phenomena in real time. To this end, the practicality of the present GHz DCS is validated by successfully capturing the 'shock waves' of balloon and firecracker explosions outdoors. This GHz single-cavity all-fiber dual-comb system promises a noteworthy improvement in acquisition speed and reliability without sacrificing measurement accuracy, anticipated as a practical tool for high-speed applications

Media 1: High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch

Originally published in Biomedical Optics Express on 01 April 2015 (boe-6-4-1340

3325287.pdf

DS-PACT of the linear polarizers. The sample contains five linear polarizers placed at different orientations. (a) Conventional PACT images, (b) amplitude images using DS-PACT, and (c) orientation angle maps of the linear polarizers at multiple dept

Targeted Next-Generation Sequencing for Clinical Diagnosis of 561 Mendelian Diseases

<div><p>Background</p><p>Targeted next-generation sequencing (NGS) is a cost-effective approach for rapid and accurate detection of genetic mutations in patients with suspected genetic disorders, which can facilitate effective diagnosis.</p><p>Methodology/Principal Findings</p><p>We designed a capture array to mainly capture all the coding sequence (CDS) of 2,181 genes associated with 561 Mendelian diseases and conducted NGS to detect mutations. The accuracy of NGS was 99.95%, which was obtained by comparing the genotypes of selected loci between our method and SNP Array in four samples from normal human adults. We also tested the stability of the method using a sample from normal human adults. The results showed that an average of 97.79% and 96.72% of single-nucleotide variants (SNVs) in the sample could be detected stably in a batch and different batches respectively. In addition, the method could detect various types of mutations. Some disease-causing mutations were detected in 69 clinical cases, including 62 SNVs, 14 insertions and deletions (Indels), 1 copy number variant (CNV), 1 microdeletion and 2 microduplications of chromosomes, of which 35 mutations were novel. Mutations were confirmed by Sanger sequencing or real-time polymerase chain reaction (PCR).</p><p>Conclusions/Significance</p><p>Results of the evaluation showed that targeted NGS enabled to detect disease-causing mutations with high accuracy, stability, speed and throughput. Thus, the technology can be used for the clinical diagnosis of 561 Mendelian diseases.</p></div

Evaluation of the stability of our method.

<p>(A) Venn diagram of S1 sequenced three times in a same batch. (B) Venn diagram of S1 sequenced three times in different batches.</p

Inconsistent genotypes detected by our method and SNP Array.

<p>Inconsistent genotypes detected by our method and SNP Array.</p

Evaluation of the stability of our method.

<p>(A) Venn diagram of S1 sequenced three times in a same batch. (B) Venn diagram of S1 sequenced three times in different batches.</p

Confirmation of inconsistent genotypes detected by targeted NGS and Snp Array using Sanger sequencing.

<p>(A) A heterozygous substitution of G with A was confirmed in the <i>TET2</i> gene in sample S1-1. (B) A Homozygous substitution of C with T was confirmed in the <i>KAL1</i> gene in sample S1-1. (C) A Homozygous substitution of C with T was confirmed in the <i>KAL1</i> gene in sample S4.</p