11 research outputs found
Image_2_Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis.tif
ObjectiveTo investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS).MethodsPubMed, Web of Science, and The National Library of Medicine (NLM) were systematically searched and the search period was between the date of database establishment and December 31, 2023. The outcome measures finally analyzed included the ALS functional rating scale/revised (ALSFRS/ALSFRS-R), forced vital capacity percentage predicted (FVC%), fatigue severity scale (FSS), and maximal expiratory pressure (MEP).ResultsA total of 13 randomized controlled trials (RCTs) were included, and 5 outcome measures were pooled and analyzed. A total of 657 patients with ALS were enrolled, with 299 in the experimental group (rehabilitation therapy, such as resistance training, endurance training, aerobic training, respiratory muscle training, and standard rehabilitation therapy) and 358 in the control group (conventional interventions, such as simple joint movements or daily stretching). The ALSFRS scores were better in the experimental group than in the control group at 0–4 months (MD = 3.36, 95% CI: 0.82, 5.91, Z = 2.59, p = 0.009) and at 5–8 months (MD = 5.00, 95% CI: −2.42, 7.58, Z = 3.80, p ConclusionRehabilitation therapy is helpful in improving the short-, medium-, and long-term global function score of patients with ALS, with positive effects on respiratory function.</p
Image_1_Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis.tif
ObjectiveTo investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS).MethodsPubMed, Web of Science, and The National Library of Medicine (NLM) were systematically searched and the search period was between the date of database establishment and December 31, 2023. The outcome measures finally analyzed included the ALS functional rating scale/revised (ALSFRS/ALSFRS-R), forced vital capacity percentage predicted (FVC%), fatigue severity scale (FSS), and maximal expiratory pressure (MEP).ResultsA total of 13 randomized controlled trials (RCTs) were included, and 5 outcome measures were pooled and analyzed. A total of 657 patients with ALS were enrolled, with 299 in the experimental group (rehabilitation therapy, such as resistance training, endurance training, aerobic training, respiratory muscle training, and standard rehabilitation therapy) and 358 in the control group (conventional interventions, such as simple joint movements or daily stretching). The ALSFRS scores were better in the experimental group than in the control group at 0–4 months (MD = 3.36, 95% CI: 0.82, 5.91, Z = 2.59, p = 0.009) and at 5–8 months (MD = 5.00, 95% CI: −2.42, 7.58, Z = 3.80, p ConclusionRehabilitation therapy is helpful in improving the short-, medium-, and long-term global function score of patients with ALS, with positive effects on respiratory function.</p
Image_4_Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis.tif
ObjectiveTo investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS).MethodsPubMed, Web of Science, and The National Library of Medicine (NLM) were systematically searched and the search period was between the date of database establishment and December 31, 2023. The outcome measures finally analyzed included the ALS functional rating scale/revised (ALSFRS/ALSFRS-R), forced vital capacity percentage predicted (FVC%), fatigue severity scale (FSS), and maximal expiratory pressure (MEP).ResultsA total of 13 randomized controlled trials (RCTs) were included, and 5 outcome measures were pooled and analyzed. A total of 657 patients with ALS were enrolled, with 299 in the experimental group (rehabilitation therapy, such as resistance training, endurance training, aerobic training, respiratory muscle training, and standard rehabilitation therapy) and 358 in the control group (conventional interventions, such as simple joint movements or daily stretching). The ALSFRS scores were better in the experimental group than in the control group at 0–4 months (MD = 3.36, 95% CI: 0.82, 5.91, Z = 2.59, p = 0.009) and at 5–8 months (MD = 5.00, 95% CI: −2.42, 7.58, Z = 3.80, p ConclusionRehabilitation therapy is helpful in improving the short-, medium-, and long-term global function score of patients with ALS, with positive effects on respiratory function.</p
Image_3_Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis.tif
ObjectiveTo investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS).MethodsPubMed, Web of Science, and The National Library of Medicine (NLM) were systematically searched and the search period was between the date of database establishment and December 31, 2023. The outcome measures finally analyzed included the ALS functional rating scale/revised (ALSFRS/ALSFRS-R), forced vital capacity percentage predicted (FVC%), fatigue severity scale (FSS), and maximal expiratory pressure (MEP).ResultsA total of 13 randomized controlled trials (RCTs) were included, and 5 outcome measures were pooled and analyzed. A total of 657 patients with ALS were enrolled, with 299 in the experimental group (rehabilitation therapy, such as resistance training, endurance training, aerobic training, respiratory muscle training, and standard rehabilitation therapy) and 358 in the control group (conventional interventions, such as simple joint movements or daily stretching). The ALSFRS scores were better in the experimental group than in the control group at 0–4 months (MD = 3.36, 95% CI: 0.82, 5.91, Z = 2.59, p = 0.009) and at 5–8 months (MD = 5.00, 95% CI: −2.42, 7.58, Z = 3.80, p ConclusionRehabilitation therapy is helpful in improving the short-, medium-, and long-term global function score of patients with ALS, with positive effects on respiratory function.</p
Meta-analysis results of common SNPs of miRNAs.
<p>Results are shown as OR 95% CI; M1: homozygote comparison; M2 heterozygote comparison; M3: dominant model; M4: recessive model;</p>*<p>for significant difference.</p
miRNA-SNPs and lung cancer.
*<p>significant association;</p><p>a: different results between screening set and validation set;</p><p>b: HR and 95% CI estimated form Kaplan-Meier curve;</p><p>c: data from the validation set; d: data from low-dose smokers of Boston case-control study.</p
Forrest plot of miRNA-196a2 rs11614913 (dominant model).
<p>Estimated by random-effect model (CC+CT vs. TT).</p
Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer
Nucleic
acid binding proteins (NABPs) mediate a broad range of essential cellular
functions. However, it is very challenging to comprehensively extract
whole cellular NABPs due to the lack of approaches with high efficiency.
To this end, carbon nanomaterials, including graphene oxide (GO),
carboxylated graphene (cG), and carboxylated carbon nanotube (cCNT),
were utilized to extract cellular NABPs in this study through a new
strategy. Our data demonstrated that GO, cG, and cCNT could extract
nearly 100% cellular DNA in vitro. Conversely, their RNA extraction
efficiencies were 60, 50, and 29%, respectively, partially explaining
why GO has the highest NABPs yield compared to cG and cCNT. We further
found that ionic bond mediated by cations between RNA and functional
groups of nanomaterials facilitated RNA absorption on nanomaterials.
About 2400 proteins were successfully identified from GO-enriched
NABPs sample, and 88% of annotated NABPs were enriched at least 2
times compared to cell lysate, indicating the high selectivity of
our strategy. The developed method was further applied to compare
the NABPs in two lung cancer cell lines with different tumor progression
abilities. According to label-free quantification results, 118 differentially
expressed NABPs were discovered and 6 candidate NABPs, including ACAA2,
GTF2I, VIM, SAMHD1, LYAR, and IGF2BP1, were successfully validated
by immunoassay. The level of SAMHD1 in the serum of lung cancer patients
was measured, which significantly increased upon cancer progression.
Our results collectively demonstrated that GO is an ideal nanomaterial
for NABPs selective extraction, which could be broadly used in varied
physiological and pathophysiological settings