Analisis Portofolio Optimal Dengan Single Index Model Untuk Meminimumkan Risiko Bagi Investor Di Bursa Efek Indonesia (Studi Pada Saham Indeks Kompas 100 Periode Februari 2010-juli 2014)

Investments can be made in the capital market, capital market instruments which are mostly attractive for investors is stock. Stock provides a return in the form of capital gains and dividends yield, not only noticing the return, investors need to pay attention to the investments risk. Unsystematis risk can be minimized by forming the optimal portfolio using one of the methods that is single index model. Study purpose is to knowing the stocks forming the optimal portfolio, the proportion of funds allocated to each stocks, the level of expectation return and risk.The method used in this research is descriptive research method with a quantitative approach. The samples used were 46 stocks in Kompas 100 Index, which meets the criteria for sampling. The results showed that 12 stocks of forming optimal portfolio, the stocks of which are UNVR, TRAM, MNCN, BHIT, JSMR, BMTR, GJTL, KLBF, AALI, CPIN, AKRA, and ASRI. Stock with highest proportion of funds is TRAM (23,52%), stock with lowest proportion of funds is AALI (0,62%). Portfolio which are formed will give return expectations by 3,05477% and carry the risk for about 0,1228%

Additional file 2 of Multidimensional self-rating biological rhythm disorder and its association with depression and anxiety symptoms among adolescents aged 11–23 years: a school-based cross-sectional study from China

Additional file 2: Table S1. Sensitivity analysis. Table S2. The distribution of the score of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA). Table S3. Sample characteristics stratified by sleep rhythm disorder (N = 3693). Table S4. Sample characteristics stratified by activity rhythm disorder (N = 3693). Table S5. Sample characteristics stratified by eating habits rhythm disorder (N = 3693). Table S6. Sample characteristics stratified by digital media use (N = 3693). Table S7. Partial coefficients between self-rating biological rhythm disorders and Depression and anxiety symptoms. Table S8. Adjusted associations between self-rating biological rhythm disorders and depression symptoms. Table S9. Adjusted associations between self-rating biological rhythm disorders and anxiety symptoms

Additional file 1 of Multidimensional self-rating biological rhythm disorder and its association with depression and anxiety symptoms among adolescents aged 11–23 years: a school-based cross-sectional study from China

Additional file 1: Fig. S1. Study participant flow diagram

Table_1_Trends of overweight and obesity prevalence in school-aged children among Henan Province from 2000 to 2019.DOCX

ObjectivesOverweight and obesity are harmful to human health. However, the latest trends of Chinese childhood overweight and obesity prevalence are not available. The aim of this study was to examine the trends from 2000 to 2019 among students in China.MethodsWe analyzed data of 66,072 students in the Chinese National Survey on Students' Constitution and Health from 2000 to 2019. Overweight and obesity were defined based on the standard formulated by the International Obesity Task Force (IOTF standard), the World Health Organization (WHO standard), and the Working Group on Obesity in China (WGOC standard), respectively. The χ2-test was used to test the trends of overweight and obesity prevalence and logistic regression was conducted to evaluate the prevalence odds ratios of boys vs. girls and urban vs. rural areas.ResultsThe prevalence of obesity/overweight and obesity combined was 6.03/23.58% (IOTF standard), 10.56/25.88% (WGOC standard) and 10.75/29.69% (WHO standard) in 2019. From 2000 to 2019, according to the WGOC standard, the prevalence increased from 2.51 to 10.56% for obesity and increased from 9.81 to 25.88% for overweight and obesity combined (P for trend ConclusionOverweight and obesity prevalence increased significantly in children and adolescents in China from 2000 to 2019. The prevalence of overweight and obesity in rural areas may contribute to a large percentage of children with overweight and obesity.</p

Proteolytic Characteristics of Cathepsin D Related to the Recognition and Cleavage of Its Target Proteins

<div><p>Cathepsin D (CD) plays an important role in both biological and pathological processes, although the cleavage characteristics and substrate selection of CD have yet to be fully explored. We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the CD cleavage sites in bovine serum albumin (BSA). We found that the hydrophobic residues at P1 were not only a preferential factor for CD cleavage but that the hydrophobicity at P1’ also contributed to CD recognition. The concept of hydrophobic scores of neighbors (HSN) was proposed to describe the hydrophobic microenvironment of CD recognition sites. The survey of CD cleavage characteristics in several proteins suggested that the HSN was a sensitive indicator for judging the favorable sites in peptides for CD cleavage, with HSN values of 0.5–1.0 representing a likely threshold. Ovalbumin (OVA), a protein resistant to CD cleavage in its native state, was easily cleaved by CD after denaturation, and the features of the cleaved peptides were quite similar to those found in BSA, where a higher HSN value indicated greater cleavability. We further conducted two-dimensional gel electrophoresis (2DE) to find more proteins that were insensitive to CD cleavage in CD-knockdown cells. Based on an analysis of secondary and three-dimensional structures, we postulated that intact proteins with a structure consisting of all α-helices would be relatively accessible to CD cleavage.</p></div

Analysis of CD cleavage characteristics in denatured OVA.

<p><i>A</i>, Sequence logos of the CD cleavage sites in native OVA (<i>left</i>) and denatured OVA (<i>right</i>). <i>B</i>, The sensitivity of denatured OVA to CD cleavage was examined via SDS-PAGE, in which the denatured protein was incubated with/without CD and pepstatin A for 3 h. <i>C</i>, The median T-HSNs, C-HSNs and U-HSNs in denatured OVA are depicted using box plots. <i>D</i>, Comparison of the HSN distributions between the cleaved and undetected peptides from denatured OVA.</p

Screening of proteins that were insensitive to CD cleavage in A549-CR cells.

<p><i>A</i>, The expression of CD in A549 cells was evaluated by Western blotting. The control was transfected with empty vector. <i>B, C</i>omparison of the 2DE images obtained from lysates of A549-CR cells treated with/without CD. The insets represent the typical 2DE images showing spots that were sensitive or insensitive to CD cleavage.</p

The CD cleavage site numbers and the occurrence frequencies of the top 6 amino acids at P1 in each protein.

<p>The numbers of CD cleavage sites in 12 proteins, the occurrence frequencies of the top 6 residues (L, F, A, Y, E and D) appearing at P1 in the CCPD and the total occurrence frequencies of the 6 residues in each protein are listed below.</p

Additional file 4 of Unhealthy lifestyles and clusters status among 3637 adolescents aged 11–23 years: a school-based cross-sectional study in China

Additional file 4. Table S1