Data_Sheet_1_Dialectical Thinking Is Linked With Smaller Left Nucleus Accumbens and Right Amygdala.docx

Our current work examined the interface between thinking style and emotional experience at both the behavioral and neuropsychological levels. Thirty-nine Chinese participants completed the triad task, and we calculated the rate of individually selected relationship pairings to overall selections to represent their holistic thinking tendencies. In addition, participants in the top one-third of the ratio score were classified into the high holistic thinking group, while those in the bottom one-third of the ratio score were classified into the low holistic thinking group. We used the sensitivity to punishment and sensitivity to reward questionnaire (SPSRQ) to examine how people elicit positive and negative affective behaviors. Additionally, we examined the volume of the amygdala and nucleus accumbens and their functional connectivity in the resting-state. We found that high holistic thinkers were much less sensitive to rewards than low holistic thinkers. In other words, individuals with high holistic thinking are less likely to pursue behaviors that have positive emotional outcomes. Furthermore, their bilateral nucleus accumbens and right amygdala volumes were smaller than those of low holistic thinkers. Hierarchical regression analysis showed that holistic thinking tendency can negatively predict the volume of the left nucleus accumbens and right amygdala. Finally, resting-state functional connectivity results showed increased functional connectivity FC between left nucleus accumbens and bilateral amygdala in high holistic thinkers. These findings provide emotion-related manifestations of thinking styles at the behavioral and neural levels.</p

Additional file 2 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 2: Figure S1

Additional file 3 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 3: Figure S2

Additional file 6 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 6: Figure S5

Additional file 5 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 5: Figure S4

Additional file 4 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 4: Figure S3

Additional file 1 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer

Additional file 1: Table S1

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge

Life Cycle Assessment of the Polyvinylidene Fluoride Polymer with Applications in Various Emerging Technologies

Polyvinylidene fluoride (PVDF) is one of the most popular fluoropolymers in the market. It is commonly used as pipes and cables, binder materials, and membrane materials. Lately, PVDF is being examined for applications in batteries, biomedical research, chemical engineering, and wastewater management. These PVDF applications cover most emerging technologies, which can be attributed to its outstanding physicochemical properties. With the global demand for PVDF in diverse technologies increasing significantly, it is imperative to quantify the environmental impacts associated with its production. Life cycle assessment (LCA) methodology is a standardized approach for evaluating the environmental impacts of novel materials. However, most previous LCA studies have not accounted for PVDF in a scientifically rigorous manner. While compiling the life cycle inventory (LCI) on PVDF, several kinds of surrogates were chosen to bridge the data gap, rather than establishing the new dataset for PVDF. When we investigate the similarities and differences between PVDF and popular surrogates regarding the synthesis pathways, adopting surrogates to replace PVDF becomes difficult. Due to the use of these surrogates, the global warming potential (GWP) calculated in the literature varies significantly, with a difference of 60.7 kg CO2 equiv between the highest and lowest estimates. After evaluating the life cycle environmental profiles of those commonly used surrogates, we find that the application of surrogates is hardly reliable; besides, the PVDF inventory dataset is underestimated. For this reason, we model the PVDF production process according to the commercialized synthesis approach and assess the cradle-to-gate impacts, which lowers uncertainty. The impact assessment on the PVDF inventory dataset results in an acceptable GWP value (55.8 kg CO2 equiv/kg PVDF), but a high cumulative energy demand (CED, 756 MJ equiv/kg PVDF), due to the large demand for chlorine during the production of vinylidene fluoride (VDF). In terms of uncertainty analysis, the upper and lower bounds for the newly developed LCI dataset for PVDF are 801 and 714 MJ equiv for CED values and 59.1 and 52.8 kg CO2 equiv for GWP values, respectively. Notably, this is the first study to develop a detailed LCI for PVDF involved in emerging technologies

Correlation table.

Correlation table.</p