内臟に發生せる稀有なる多發性神經纎維腫症の一剖檢例

Information on the 74 candidate blast resistant genes in LAFBRs. (XLSX 90 kb

Preparation of Highly Uniform Polyurea Microspheres through Precipitation Polymerization and Their Characterization

Uniform polyurea (PU) microspheres were prepared through precipitation polymerization of isophorone diisocyanate (IPDI) in water–acetone mixed solvent, under mechanical oscillation and quiescent conditions. Higher yield with better uniformity for the microspheres was achieved under the quiescent process. The preparation was therefore optimized for the quiescent process. The maximal IPDI loading reached 11.0 wt % with the yield of the microspheres of 88.5%. With acetone replaced by acetonitrile, this yield was increased further to 93.5% combined with also a higher IPDI loading of 15.0 wt % at the same time. The chemical structure of PU was studied using nuclear magnetic resonance. PU microspheres, insoluble in most of organic solvents tested, were dissolved in <i>m</i>-cresol at 30 °C and in acetic acid at 66 °C. These results showed that the PU microspheres consisted of only linear polymers. This work provides therefore a simple and promising protocol for large-scale production of highly uniform polymer microspheres through precipitation polymerization without any additives

Phase Transition and Fluorescence Emission of Multiresponsive Poly(ethylene glycol-<i>co</i>-siloxane) and Its Application for Uric Acid Detection

In recent years, multiresponsive polymers with nonconjugated chromophores featuring cluster-triggered emission (CTE) have attracted significant attention due to their wide applications and interests in fundamental studies. There is a lack of studies correlating the fluorescent properties to their distinct stimuli-responsiveness although CTE materials have been well studied. Herein, we introduced a poly(ethylene glycol)-polysiloxane copolymer, PEG-Si, which exhibits responsiveness to temperature, pH, CO2, and salinity, with adjustable phase transition and reversible fluorescence. PEG-Si was synthesized by a catalyst-free aza-Michael addition of PEG diacrylate with bis(3-aminopropyl)-tetramethyldisiloxane in dichloromethane. The structure of PEG-Si was characterized using various spectroscopic methods such as NMR and Fourier transform infrared spectroscopy (FTIR). The light transmittance and fluorescence performance of PEG-Si were measured at different temperatures under varying conditions, including polymer composition, concentration, pH, and bubbled CO2, to observe their evolution. The relationship between fluorescence properties and the phase transition process was described. The results demonstrate that PEG-Si can be used as a temperature and pH fluorescence thermometer and biosensor for detection of uric acid with a detection limit of 1.02 μmol/L. This study proposes a practical strategy for designing multiresponsive polymers with CTE features and provides significant insights into the correlation between stimuli-responsiveness and fluorescent properties, which contributes to the development of advanced materials with diverse applications

Free-Standing Three-Dimensional Graphene/Manganese Oxide Hybrids As Binder-Free Electrode Materials for Energy Storage Applications

Novel three-dimensional (3D) hybrid materials, i.e., free-standing 3D graphene-supported MnO₂ nanosheets, are prepared by a simple and controllable solution-phase assembly process. Characterization results show that MnO₂ nanosheets are uniformly anchored on a 3D graphene framework with strong adhesion and the integral hybrids show desirable mechanical strength. Such unique structure of 3D graphene/MnO₂ hybrids thus provides the right characteristics of binder-free electrode materials and could enable the design of different kinds of high-performance energy storage devices. Especially, an advanced asymmetric supercapacitor is built by using a 3D graphene/MnO₂ hybrid and a 3D graphene as two electrodes, and it is able to work reversibly in a full operation voltage region of 0–3.5 V in an ionic liquid electrolyte and thus exhibits a high energy density of 68.4 Wh/kg. As the cathode materials for Li–O₂ and Li–MnO₂ batteries, the 3D graphene/MnO₂ hybrids exhibit outstanding performances, including good catalytic capability, high reversible capacity and desirable cycling stability. The results presented here may pave a way for new promising applications of such 3D graphene/MnO₂ hybrids in advanced electrochemical energy storage devices

Bilateral OCCCs in a 47-year-old woman (Patient 10 in Tables 1 and 2) presenting with abdominal distension for 2 months.

<p><b>A-C</b> Axial (<b>A</b>), sagittal T2WI (<b>B</b>) and plain (non-contrast) T1WI (<b>C</b>) showing a left-side, large, well-defined multilocular cystic mass with a few irregular lumen solid protrusions and many irregular septations (> 3 mm, arrow) and similar MRI findings of a right-side, small, multilocular cystic mass with protrusions (arrow head). The SI of the cyst was high on T2WIs and low on T1WI. The solid protrusions had heterogeneous iso-slightly high SI on T2WIs and iso-SI on T1WI. Bulk ascites were detected. <b>D, E</b> Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions and septations (arrow). <b>F</b> The tumor shows a cyst lined with hobnail cells. Secretions were found in the lumen of the cyst. (HE 40 & 10).</p

Table S6

<p>Functional annotation analysis of has-miR-4640-5p</p

Table S1.docx

Table S1: The primers used in this study

MRI characteristics of 21 OCCCs in 19 patients.

<p>Note:*Size: the largest tumor diameter observed on axial scans. Irreg., irregular; WD, well-defined; ID, ill-defined; Multi,multilocular cystic mass; Uni,unilocular cystic mass; Iso-,isointensity signal; High, high signal intensity; Low, low signal intensity; Very high, isointensity of fat on T1WIs; Very high on T2WIs, same or higher than the intensity of urine or spinal fluid; Inequality of size +, a few; Inequality of size + +, many in number; Signal intensity, SI; Hetero-, heterogeneous</p><p>MRI characteristics of 21 OCCCs in 19 patients.</p

An OCCC in a 59-year-old woman (Patient 7 in Tables 1 and 2) with frequent and urgent micturition and a pelvic lump.

<p><b>A-C</b> Axial (<b>A</b>), coronal T2WI (<b>B</b>) and plain (non-contrast) T1WI (<b>C</b>) showing a large and irregular unilateral, multilocular well-defined cystic mass with many irregularities and a few oval lumen solid protrusions. The septations were < 3 mm (arrow). The SI of the cyst was very high on T2WIs and high on T1WI. The solid protrusions had heterogeneous intermediate SI on T2WIs and T1WI (<b>A-C</b>). <b>D, E</b> Enhanced T1WIs showing markedly heterogeneous and prolonged enhancement solid protrusions, with nonenhanced portions (arrow) indicating effusion, as shown by pathology results. The thickened wall was enhanced. <b>F</b> The tumor shows a solid pattern with clear cells. (HE 40 & 10).</p