Single- versus Multi-Proton-Coupled Rydberg-State Electron Transfer in Amine Clusters

Amino fragments (−NH₂) are well-known to exist widely in biological systems and their protonated forms are inclined to trap electrons and form Rydberg radicals (−NH₃^•) in the electron-excess systems. Taking CH₃–NH₃⁺ as a mimicking group of the protonated alkylamine side-chain of lysine, ab initio calculations indicate that the proton/electron cooperatively transfer from CH₃NH₃ to CH₃NH₂ via a single-proton-coupled Rydberg-state electron transfer (ET) mechanism with an Rydberg-orbital channel for ET outside the −NH_n hydrogens and a N–H⁺ → N proton migrating pathway. Besides, in big amine clusters, CH₃NH₃·(NH₃)_<i>n</i>·NH₂CH₃ (<i>n</i> = 1–3), the proton/electron transfer along an amine wire is stepwise and every step takes place via the similar single-proton-coupled Rydberg-state ET mechanism with low energy barrier (<4.0 kcal/mol). When a water chain, (H₂O)_<i>n</i> (<i>n</i> = 1–3), lies between CH₃NH₃ and NH₂CH₃ as a bridge, the energy barriers (8.5–15.0 kcal/mol) of proton/electron cooperatively transfer between CH₃NH₃ and NH₂CH₃ are raised significantly as compared to these of the pure amine wires (<4.0 kcal/mol). We attribute this fact to the combined effects of the proton binding energies and electron affinities of CH₃NH₂ and H₂O. Interestingly, different from the amine-wire case, movement of the solvated electron along the water-wire can promote two or three protons synchronously moving at the same direction. This process can be described in terms of a multi-proton-coupled solvated-ET mechanism

One polynuclear copper(II) complex based on salicylaldehyde phenoxyacylhydrazone: structural and magnetic studies

<div><p>One new copper(II) complex with a multidentate Schiff-base ligand salicylaldehyde phenoxyacylhydrazone (H₂<i>L</i>), {[Cu₄(<i>L</i>)₄(DMF)]·DMF}_n (<b>1</b>) has been synthesized and structurally characterized. Complex <b>1</b> exhibits a coordination polymer with a 1-D infinite chain-like structure, resulting from the Cu(II) centers linked by N–N single bonds. Magnetic behavior of <b>1</b> shows that it is antiferromagnetic.</p></div

Synthesis of Mg-Doped Ordered Mesoporous Pd–Al₂O₃ with Different Basicity for CO, NO, and HC Elimination

Employing NH₄HCO₃ as pore-enlarging agent and P123 as a template agent, ordered mesoporous Mg-doped γ-Al₂O₃ with different basicity and large surface area have been successfully synthesized by a facile sol–gel approach by adjusting the content of magnesium and pH value. Specifically, the result alumina calcined at 1000 °C with large specific surface area (234.4 m² g^–1) and high pore volume (0.72 cm³ g^–1) was obtained when the Mg content was 9 wt %. These materials with ordered mesostructure and advantageous structural properties were utilized as carriers of Pd–Al₂O₃ catalysts for the catalytic reaction of simulated exhaust automobile gases including CO, NO, and hydrocarbon (HC). The results revealed that the high catalytic performance of Pd/9Mg-OMA originated from its more appropriate basicity, greater PdO dispersion, and higher surface area

Average hippocampal volume (across right and left sides) in high (solid) and low (dashed) LEQ groups at baseline and 3 year follow-up.

<p>Error bars represent standard error of mean. *p-value after covariate control for age, gender, hypertension, baseline volume and total intracranial volume.</p

Scatterplot of total LEQ and hippocampal volume at three year follow-up.

<p>Zero-order correlation is shown in dashed line (r = 0.42, p = 0.006).</p

Examples of hippocampal volumes from a high and low LEQ individual at the 3 year follow-up stage.

<p>Note the relative increase in the volume of the inferior horn of the lateral ventricle. Average volumes refer to the mean across right and left sides. Right hippocampus tracing shown in red.</p

sj-docx-1-jic-10.1177_08850666241228841 - Supplemental material for Efficacy and Safety of Nirmatrelvir/Ritonavir in Severe Hospitalized Patients with COVID-19 and in Patients at High Risk for Progression to Critical Illness: A Real-World Study

Supplemental material, sj-docx-1-jic-10.1177_08850666241228841 for Efficacy and Safety of Nirmatrelvir/Ritonavir in Severe Hospitalized Patients with COVID-19 and in Patients at High Risk for Progression to Critical Illness: A Real-World Study by Xiaohua Chen, Ying Zhu, Leer Shen, Dan Zhou, Nannan Feng and Qiang Tong in Journal of Intensive Care Medicine</p

The Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis

<div><p>Background</p><p>Telomeres are essential for chromosomal integrity and stability. Shortened telomere length (TL) has been associated with risk of cancers and aging-related diseases. Several studies have explored associations between TL and cancer prognosis, but the results are conflicting.</p><p>Methods</p><p>Prospective studies on the relationship between TL and cancer survival were identified by a search of PubMed up to May 25, 2015. There were no restrictions on the cancer type or DNA source. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Meta-analysis approaches were conducted to determine pooled relative risks and 95% confidence intervals.</p><p>Results</p><p>Thirty-three articles containing forty-five independent studies were ultimately involved in our meta-analysis, of which twenty-seven were about overall cancer survival and eighteen were about cancer progression. Short TL was associated with increased cancer mortality risk (RR = 1.30, 95%CI: 1.06–1.59) and poor cancer progression (RR = 1.44, 95%CI: 1.10–1.88), both with high levels of heterogeneity (<i>I²</i> = 83.5%, <i>P</i> = 0.012for overall survival and <i>I²</i> = 75.4%, <i>P</i> = 0.008 for progression). TL was an independent predictor of overall cancer survival and progression in chronic lymphocytic leukemia. Besides, short telomeres were also associated with increased colorectal cancer mortality and decreased overall survival of esophageal cancer, but not in other cancers. Cancer progression was associated with TL in Asian and America populations and short TL predicted poor cancer survival in older populations. Compared with tumor tissue cells, TL in blood lymphocyte cells was better for prediction. In addition, the associations remained significant when restricted to studies with adjustments for age, with larger sample sizes, measuring TL using southern blotting or estimating risk effects by hazard ratios.</p><p>Conclusion</p><p>Short TL demonstrated a significant association with poor cancer survival, suggesting the potential prognostic significance of TL. Additional large well-designed studies are needed to confirm our findings.</p></div

Cohort characteristics at baseline and follow-up.

<p>27 follow-up subjects either refused or were not able to attend follow-up MRI or had scans with insufficient quality for quantitative analysis. There were no significant demographic or behavioural differences between those that did or did not undergo MRI at 3 years (p-value¹). All p-values refer to t-test comparisons except for Chi-square analysis marked^*.</p

Characteristics of included studies.

<p>^a: Mean or middle point of follow-up time.</p><p>Abbreviations: ESCC: esophageal squamous cell carcinoma, CLL: chronic lymphocytic leukemia, NSCLC: non-small-cell lung cancer, HCC: hepatocellular carcinoma, ccRCC: clear cell renal cell carcinoma, MPN: myeloproliferative neoplasms, AML: acute myelocytic leukemia, NB: neuroblastoma, HNSCC: head and neck squamous cell carcinoma, qPCR: quantitative polymerase chain reaction, FISH: fluorescence in situ hybridization-based approach.</p><p>Characteristics of included studies.</p