Research on hydroxyethyl ammonium O,O′-diphenyl dithiophosphate: Synthesis, characterization, surface activity and corrosion inhibition performance

Hydroxyethyl ammonium O,O′-diphenyl dithiophosphate (HADD) acting as a surfactant and corrosion inhibitor was successfully synthesized and characterized by FT-IR, 1H NMR and single crystal X-ray diffraction. Meanwhile, the inhibition effect of HADD on Q235 steel (Q235s) corrosion in H2SO4 solution was studied by weight loss and potentiodynamic polarization measurements. HADD turned out to be an effective corrosion inhibitor and the inhibition efficiency increased with HADD concentration increasing, and significantly decreased with increasing both temperature and H2SO4 concentration. Potentiodynamic polarization measurements indicated that HADD was a mixed-type inhibitor. </p

Retinoic Acid-Activated Ndrg1a Represses Wnt/β-catenin Signaling to Allow <i>Xenopus</i> Pancreas, Oesophagus, Stomach, and Duodenum Specification

<div><p>How cells integrate multiple patterning signals to achieve early endoderm regionalization remains largely unknown. Between gastrulation and neurulation, retinoic acid (RA) signaling is required, while Wnt/β-catenin signaling has to be repressed for the specification of the pancreas, oesophagus, stomach, and duodenum primordia in <i>Xenopus</i> embryos. In attempt to screen for RA regulated genes in <i>Xenopus</i> endoderm, we identified a direct RA target gene, N-myc downstream regulated gene 1a (<i>ndrg1a</i>) that showed expression early in the archenteron roof endoderm and late in the developing pancreas, oesophagus, stomach, and duodenum. Both antisense morpholino oligonucleotide mediated knockdown of <i>ndrg1a</i> in <i>Xenopus laevis</i> and the transcription activator-like effector nucleases (TALEN) mediated disruption of <i>ndrg1</i> in <i>Xenopus tropicalis</i> demonstrate that like RA signaling, Ndrg1a is specifically required for the specification of <i>Xenopus</i> pancreas, oesophagus, stomach, and duodenum primordia. Immunofluorescence data suggest that RA-activated Ndrg1a suppresses Wnt/β-catenin signaling in <i>Xenopus</i> archenteron roof endoderm cells. Blocking Wnt/β-catenin signaling rescued Ndrg1a knockdown phenotype. Furthermore, overexpression of the putative Wnt/β-catenin target gene Atf3 phenocopied knockdown of Ndrg1a or inhibition of RA signaling, while Atf3 knockdown can rescue Ndrg1a knockdown phenotype. Lastly, the pancreas/stomach/duodenum transcription factor Pdx1 was able to rescue Atf3 overexpression or Ndrg1a knockdown phenotype. Together, we conclude that RA activated Ndrg1a represses Wnt/β-catenin signaling to allow the specification of pancreas, oesophagus, stomach, and duodenum progenitor cells in <i>Xenopus</i> embryos.</p></div

Additional file 1 of Lack of causal association between heart failure and osteoporosis: a Mendelian randomization study

Additional file 1: Table S1. STROBE-MR Checklist [20]. Table S2. Genome-wide significant SNPs associated with HF and their association with BMDs and fracture. Table S3. Evaluation of heterogeneity and directional pleiotropy using different methods

DataSheet1_Causal associations between CD40/CD40L and aortic diseases: A mendelian randomization study.PDF

Background: CD40 and CD40L have been reported as associated with aortic dissection (AD) and aortic aneurysm (AA), but the causality of the associations has not been established yet.Methods: We conducted a two-sample Mendelian randomization (MR) study to assess the causal inference between CD40/CD40L and aortic diseases including AD and AA. The instrumental variables (IVs) for CD40 and CD40L were selected from a high-quality protein quantitative trait loci dataset released by a genomic study involving 30,931 individuals of European ancestry. The genome-wide association studies summary statistics for AD and AA were from the FinnGen Release 7, with 288638 controls for all outcomes of interests, 680 cases for AD and 6,092 cases for AA, also from European ancestry. For AA subtypes, there were 5,881 cases of thoracic AA (TAA) and 2,434 cases of abdominal AA (AAA) respectively. Inverse-variance weighted and Wald ratio were applied for calculating causal estimates. Horizontal pleiotropy and heterogeneity were assessed using MR-Egger regression analysis and Cochran Q test, respectively. Leave-one-out analyses were further performed.Results: Three single-nucleotide polymorphisms (SNPs) for CD40 and one SNP for CD40L were selected as IVs. We found genetic proxied CD40 levels inversely associated with the risk of AD (odds ratio [OR]: 0.777, 95% confidence interval [CI]: 0.618–0.978, p = 0.031) and AA (OR: 0.905, 95% CI: 0.837–0.978, p = 0.012), consistent across TAA (both p Conclusion: Our MR study provides evidence supporting the causal association between CD40 and the reduced risks of both AD and AA.</p

Facile one-step chemical deposition process to fabricate superhydrophobic porous Cu films on Al alloy surface

<p>Herein, we demonstrated a facile one-step fabrication strategy combining both chemical deposition and self-assembly of stearic acid for the fabrication of superhydrophobic porous Cu films on the Al substrates. The scanning electron microscopy and white light interferometer showed that the multi-scale porous structures comprising micron-sized pores and nano-sized fishbone-like dendrites were formed on the sample. X-ray diffraction and Fourier-transform infrared spectrophotometer revealed the deposition of Cu and the grafting process of stearic acid on the films. In addition, the formation mechanism of the superhydrohobic surface was explained, and the processing conditions were investigated to determine their effects on the wettability. The resultant sample revealed superhydrophobicity with a water contact angle of 159 ± 1°, a sliding angle of ca. 4° and great bouncing behaviour of water droplets. Moreover, such a surface exhibited a stable superhydrophobicity even after six weeks of ambient air exposure.</p

Dual-Phase Inspired Soft Electronic Sensors with Programmable and Tunable Mechanical Properties

Wearable and stretchable sensors are important components to strictly monitor the behavior and health of humans and attract extensive attention. However, traditional sensors are designed with pure horseshoes or chiral metamaterials, which restrict the biological tissue engineer applications due to their narrow regulation ranges of the elastic modulus and the poorly adjustable Poisson’s ratio. Inspired by the biological spiral microstructure, a dual-phase metamaterial (chiral-horseshoes) is designed and fabricated in this work, which possesses wide and programmable mechanical properties by tailoring the geometrical parameters. Experimental, numerical, and theoretical studies are conducted, which reveal that the designed microstructures can reproduce mechanical properties of most natural animals such as frogs, snakes, and rabbits skin. Furthermore, a flexible strain sensor with the gauge factor reaching 2 under 35% strain is fabricated, which indicates that the dual-phase metamaterials have a stable monitoring ability and can be potentially applied in the electronic skin. Finally, the flexible strain sensor is attached on the human skin, and it can successfully monitor the physiological behavior signals under various actions. In addition, the dual-phase metamaterial could combine with artificial intelligence algorithms to fabricate a flexible stretchable display. The dual-phase metamaterial with negative Poisson’s ratio could decrease the lateral shrinkage and image distortion during the stretching process. This study offers a strategy for designing the flexible strain sensors with programmable, tunable mechanical properties, and the fabricated soft and high-precision wearable strain sensor can accurately monitor the skin signals under different human motions and potentially be applied for flexible display

Dual-Phase Inspired Soft Electronic Sensors with Programmable and Tunable Mechanical Properties

Wearable and stretchable sensors are important components to strictly monitor the behavior and health of humans and attract extensive attention. However, traditional sensors are designed with pure horseshoes or chiral metamaterials, which restrict the biological tissue engineer applications due to their narrow regulation ranges of the elastic modulus and the poorly adjustable Poisson’s ratio. Inspired by the biological spiral microstructure, a dual-phase metamaterial (chiral-horseshoes) is designed and fabricated in this work, which possesses wide and programmable mechanical properties by tailoring the geometrical parameters. Experimental, numerical, and theoretical studies are conducted, which reveal that the designed microstructures can reproduce mechanical properties of most natural animals such as frogs, snakes, and rabbits skin. Furthermore, a flexible strain sensor with the gauge factor reaching 2 under 35% strain is fabricated, which indicates that the dual-phase metamaterials have a stable monitoring ability and can be potentially applied in the electronic skin. Finally, the flexible strain sensor is attached on the human skin, and it can successfully monitor the physiological behavior signals under various actions. In addition, the dual-phase metamaterial could combine with artificial intelligence algorithms to fabricate a flexible stretchable display. The dual-phase metamaterial with negative Poisson’s ratio could decrease the lateral shrinkage and image distortion during the stretching process. This study offers a strategy for designing the flexible strain sensors with programmable, tunable mechanical properties, and the fabricated soft and high-precision wearable strain sensor can accurately monitor the skin signals under different human motions and potentially be applied for flexible display

Dual-Phase Inspired Soft Electronic Sensors with Programmable and Tunable Mechanical Properties

Wearable and stretchable sensors are important components to strictly monitor the behavior and health of humans and attract extensive attention. However, traditional sensors are designed with pure horseshoes or chiral metamaterials, which restrict the biological tissue engineer applications due to their narrow regulation ranges of the elastic modulus and the poorly adjustable Poisson’s ratio. Inspired by the biological spiral microstructure, a dual-phase metamaterial (chiral-horseshoes) is designed and fabricated in this work, which possesses wide and programmable mechanical properties by tailoring the geometrical parameters. Experimental, numerical, and theoretical studies are conducted, which reveal that the designed microstructures can reproduce mechanical properties of most natural animals such as frogs, snakes, and rabbits skin. Furthermore, a flexible strain sensor with the gauge factor reaching 2 under 35% strain is fabricated, which indicates that the dual-phase metamaterials have a stable monitoring ability and can be potentially applied in the electronic skin. Finally, the flexible strain sensor is attached on the human skin, and it can successfully monitor the physiological behavior signals under various actions. In addition, the dual-phase metamaterial could combine with artificial intelligence algorithms to fabricate a flexible stretchable display. The dual-phase metamaterial with negative Poisson’s ratio could decrease the lateral shrinkage and image distortion during the stretching process. This study offers a strategy for designing the flexible strain sensors with programmable, tunable mechanical properties, and the fabricated soft and high-precision wearable strain sensor can accurately monitor the skin signals under different human motions and potentially be applied for flexible display

Dual-Phase Inspired Soft Electronic Sensors with Programmable and Tunable Mechanical Properties

Wearable and stretchable sensors are important components to strictly monitor the behavior and health of humans and attract extensive attention. However, traditional sensors are designed with pure horseshoes or chiral metamaterials, which restrict the biological tissue engineer applications due to their narrow regulation ranges of the elastic modulus and the poorly adjustable Poisson’s ratio. Inspired by the biological spiral microstructure, a dual-phase metamaterial (chiral-horseshoes) is designed and fabricated in this work, which possesses wide and programmable mechanical properties by tailoring the geometrical parameters. Experimental, numerical, and theoretical studies are conducted, which reveal that the designed microstructures can reproduce mechanical properties of most natural animals such as frogs, snakes, and rabbits skin. Furthermore, a flexible strain sensor with the gauge factor reaching 2 under 35% strain is fabricated, which indicates that the dual-phase metamaterials have a stable monitoring ability and can be potentially applied in the electronic skin. Finally, the flexible strain sensor is attached on the human skin, and it can successfully monitor the physiological behavior signals under various actions. In addition, the dual-phase metamaterial could combine with artificial intelligence algorithms to fabricate a flexible stretchable display. The dual-phase metamaterial with negative Poisson’s ratio could decrease the lateral shrinkage and image distortion during the stretching process. This study offers a strategy for designing the flexible strain sensors with programmable, tunable mechanical properties, and the fabricated soft and high-precision wearable strain sensor can accurately monitor the skin signals under different human motions and potentially be applied for flexible display

Dual-Phase Inspired Soft Electronic Sensors with Programmable and Tunable Mechanical Properties

Wearable and stretchable sensors are important components to strictly monitor the behavior and health of humans and attract extensive attention. However, traditional sensors are designed with pure horseshoes or chiral metamaterials, which restrict the biological tissue engineer applications due to their narrow regulation ranges of the elastic modulus and the poorly adjustable Poisson’s ratio. Inspired by the biological spiral microstructure, a dual-phase metamaterial (chiral-horseshoes) is designed and fabricated in this work, which possesses wide and programmable mechanical properties by tailoring the geometrical parameters. Experimental, numerical, and theoretical studies are conducted, which reveal that the designed microstructures can reproduce mechanical properties of most natural animals such as frogs, snakes, and rabbits skin. Furthermore, a flexible strain sensor with the gauge factor reaching 2 under 35% strain is fabricated, which indicates that the dual-phase metamaterials have a stable monitoring ability and can be potentially applied in the electronic skin. Finally, the flexible strain sensor is attached on the human skin, and it can successfully monitor the physiological behavior signals under various actions. In addition, the dual-phase metamaterial could combine with artificial intelligence algorithms to fabricate a flexible stretchable display. The dual-phase metamaterial with negative Poisson’s ratio could decrease the lateral shrinkage and image distortion during the stretching process. This study offers a strategy for designing the flexible strain sensors with programmable, tunable mechanical properties, and the fabricated soft and high-precision wearable strain sensor can accurately monitor the skin signals under different human motions and potentially be applied for flexible display