Additional file 1 of LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma

Supplementary Material

Subgroup results of RFS and heterogeneity test.

<p>Subgroup results of RFS and heterogeneity test.</p

Subgroup results of PFS and heterogeneity test.

<p>Subgroup results of PFS and heterogeneity test.</p

Forest plots of HRs estimated for the relationship between p53 expression and RFS (A) or PFS (B) among NMIBC patients treated with BCG.

<p>Forest plots of HRs estimated for the relationship between p53 expression and RFS (A) or PFS (B) among NMIBC patients treated with BCG.</p

Flowchart of study selection.

<p>Flowchart of study selection.</p

p53 Status Correlates with the Risk of Recurrence in Non-Muscle Invasive Bladder Cancers Treated with Bacillus Calmette–Guérin: A Meta-Analysis

<div><p>Objective</p><p>Published studies have yielded inconsistent results on the relationship between p53 status and the prognosis of non-muscle invasive bladder cancer (NMIBC) treated with Bacillus Calmette–Guérin (BCG) intravesical therapy. Therefore, we performed a meta-analysis to evaluate the prognostic value of p53 in NMIBC treated with BCG.</p><p>Methods</p><p>We systematically searched for relevant literature in PubMed, EMBASE, CNKI, and Chinese Wanfang databases. Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined as the effect size (ES) across studies for recurrence-free survival (RFS) and progression-free survival (PFS).</p><p>Results</p><p>A total of 11 studies, consisting of 1,049 participants, met the criteria. Overall, there was no clear relationship between p53 status and RFS or PFS for NMIBC patients treated with BCG (HR: 1.40, 95% CI: 0.91-2.16; HR: 1.37, 95% CI: 0.90-2.09, respectively). Obvious heterogeneity was observed across the studies (I² = 69.5%, <i>P</i> = 0.001; I² = 44.7%, <i>P</i> = 0.081, respectively). In stratified analysis by region, p53 overexpression was a predictor of poor RFS in Asian populations (HR: 1.57, 95% CI: 1.08-2.27). In addition, after excluding the studies that possibly contributed to the heterogeneity by the Galbraith plot, the overall association for RFS became statistically significant (HR: 1.38 95% CI: 1.08-1.77) without evidence of heterogeneity (I² = 0.0%, <i>P</i> = 0.499).</p><p>Conclusion</p><p>This meta-analysis suggests that p53 overexpression in NMIBC patients treated with BCG may be associated with RFS, especially in Asian populations. Because of the heterogeneity and other limitations, further studies with rigid criteria and large populations are still warranted to confirm our findings.</p></div

Main characteristics of all studies included in this meta-analysis.

<p>No., number; NMIBC, non-muscle-invasive bladder cancer; RFS, recurrence-free survival; PFS, progression-free survival.</p><p>Main characteristics of all studies included in this meta-analysis.</p

Galbraith plot analysis was used to evaluate heterogeneity.

<p>It suggested that two studies were the potential source of heterogeneity for RFS (A), while one for PFS (B).</p

Subgroup results of RFS and heterogeneity test.

<p>Subgroup results of RFS and heterogeneity test.</p

Enhanced Generation of Reactive Oxygen Species via Piezoelectrics based on p–n Heterojunctions with Built-In Electric Field

Tuning the charge transfer processes through a built-in electric field is an effective way to accelerate the dynamics of electro- and photocatalytic reactions. However, the coupling of the built-in electric field of p–n heterojunctions and the microstrain-induced polarization on the impact of piezocatalysis has not been fully explored. Herein, we demonstrate the role of the built-in electric field of p-type BiOI/n-type BiVO4 heterojunctions in enhancing their piezocatalytic behaviors. The highly crystalline p–n heterojunction is synthesized by using a coprecipitation method under ambient aqueous conditions. Under ultrasonic irradiation in water exposed to air, the p–n heterojunctions exhibit significantly higher production rates of reactive species (·OH, ·O2–, and 1O2) as compared to isolated BiVO4 and BiOI. Also, the piezocatalytic rate of H2O2 production with the BiOI/BiVO4 heterojunction reaches 480 μmol g–1 h–1, which is 1.6- and 12-fold higher than those of BiVO4 and BiOI, respectively. Furthermore, the p–n heterojunction maintains a highly stable H2O2 production rate under ultrasonic irradiation for up to 5 h. The results from the experiments and equation-driven simulations of the strain and piezoelectric potential distributions indicate that the piezocatalytic reactivity of the p–n heterojunction resulted from the polarization intensity induced by periodic ultrasound, which is enhanced by the built-in electric field of the p–n heterojunctions. This study provides new insights into the design of piezocatalysts and opens up new prospects for applications in medicine, environmental remediation, and sonochemical sensors