sj-docx-1-tar-10.1177_17534666231199679 – Supplemental material for Novel inflammatory biomarkers in the prognosis of COVID-19

Supplemental material, sj-docx-1-tar-10.1177_17534666231199679 for Novel inflammatory biomarkers in the prognosis of COVID-19 by Kegang Zhan, Luhan Wang, Hao Lin, Xiaoyu Fang, Hong Jia and Xiangyu Ma in Therapeutic Advances in Respiratory Disease</p

Data_Sheet_1_The impact of the COVID-19 pandemic on palliative care practice: A survey of clinical oncologists.pdf

BackgroundPalliative care is an essential intervention to improve the quality of life for patients with cancer, whereas the ongoing COVID-19 pandemic poses a challenge to supportive and palliative care providers. This survey aims to explore the current status of palliative care practice for cancer and the influence of COVID-19, from the perspective of oncologists.MethodsThe semi-structure electronic questionnaire was designed. Mixed-mode surveys including electronic questionnaires, face-to-face interactions, and telephone interviews were adopted according to the willingness of respondents. Face-to-face and telephone interviews were based on same questions in the online questionnaire. Participants working in cancer-related departments with frontline palliative care experience during the COVID-19 outbreak were included. Surveys covered experiences and perspectives regarding the impact of COVID-19 on clinical work, personal lives, and palliative care practice. Suggestions on coping strategies were further proposed and qualitatively analyzed.ResultsThirty-seven oncologists participated in this study from September 2021 to January 2022. The majority of them believed COVID-19 significantly and negatively affected their clinical work routines (75.7%), personal daily lives (67.6%), and palliative care practice (64.9%). Most specialists considered that currently the palliative care system remained underdeveloped (73.0%), and other factors besides COVID-19 were associated with this situation (78.4%). Seventeen participants further made suggestions on how to promote palliative care during COVID-19, and three themes emerged through the qualitative analysis: (1) Remote or online service (88.2%); (2) Publicity, education, or shared decision-making for patients (29.4%); (3) Guidelines, training, or programs for care providers (23.6%).ConclusionOncologists consider that COVID-19 has an adverse impact on their palliative care practice and daily routine. In addition to COVID-19, other factors affecting palliative care should not be neglected. Corresponding measures are warranted to encourage palliative care practice during COVID-19.</p

Bimetallic Ag₁₂₅Cu₈ Nanocluster, Structure Determination, and Nonlinear Optical Properties

The atomic precision of the subnanometer nanoclusters has provided sound proof on the structural correlation of metal complexes and larger-sized metal nanoparticles. Herein, we report the synthesis, crystallography, structural characterization, electrochemistry, and optical properties of a 133-atom intermetallic nanocluster protected by 57 thiolates (3-methylbenzenethiol, abbreviated as m-MBTH) and 3 chlorides, with the formula of Ag125Cu8(m-MBT)57Cl3. This is the largest Ag–Cu bimetallic cluster ever reported. Crystallographic analysis revealed that the nanocluster has a three-layer concentric core–shell structure, Ag7@Ag47@Ag71Cu8S57Cl3, and the Ag54 metal kernel adopts a D5h symmetry. The nuclei number is between that of the previously reported large silver cluster [Ag136(SR)64Cl3Ag0.45]− and the large silver-rich cluster Au130–xAgx(SR)55 (x = 98). All these three clusters bear a similar metallic core structure, while the main structural difference lies in the shell motif structures. Electron counting revealed an open electron shell with 73 delocalized electrons, which was verified by the electron paramagnetic resonance analysis. The DPV electrochemical measurement indicates a multielectron state quantization double-layer charging shape and single-electron sequential charging and discharging characteristic of the AgCu alloy cluster. In addition, the open-hole Z-scan test reveals the nonlinear optical absorption (2–3 optical absorption in the NIR-II/III region) of Ag125Cu8 nanoclusters

Nanoporous CeO₂‑Decorated Cu-SmMn₂O₅ Composite Mullite Oxide Catalyst for Toluene Oxidation

Mullite-type AMn2O5 materials represent a group of promising candidates to substitute noble metal catalysts for the catalytic removal of volatile organic compounds (VOCs). When applied to catalytic oxidation of aromatic hydrocarbons such as toluene, AMn2O5 exhibits undesirable performance due to its poor intrinsic activity of oxygen species, leading to a light-off temperature above 250 °C. In this work, we have developed a synthesis route combining a two-step calcination and cation-exchange process to prepare a nanoporous CeO2-decorated Cu-SmMn2O5 composite mullite oxide catalyst applied in toluene oxidation. The best performing sample reached 90% toluene conversion at 190 °C, surpassing other transition metal oxide catalysts. Comprehensive characterizations reveal that Cu ion doping into the crystal lattice of the mullite phase is achieved via the cation-exchange process. In this catalyst design, surface CeO2 decoration and Cu doping promote the reduction ability and improve oxygen species activity to accelerate toluene oxidation. Overall, this work provides a strategy to prepare composite mullite oxide catalysts with high performance in the removal of VOCs, broadening the industrial application prospects of mullite-type materials

The Pivotal Radical Intermediate [Au₂₁(SR)₁₅]⁺ in the Ligand-Exchange-Induced Size-Reduction of [Au₂₃(SR)₁₆]⁻ to Au₁₆(SR)₁₂

The atomic precision of sub-nanometer-sized metal nanoclusters makes it possible to elucidate the kinetics of metal nanomaterials from the molecular level. Herein, the size reduction of an atomically precise [Au23(CHT)16]− (HCHT = cyclohexanethiol) cluster upon ligand exchange with HSAdm (1-adamantanethiol) has been reported. During the 16 h conversion of [Au23(CHT)16]− to Au16(SR)12, the neutral 6e Au21(SR)15, and its 1e-reduction state, i.e. the 5e, cationic radical, [Au21(SR)15]+, are active intermediates to account for the formation of thermodynamically stable Au16 products. The combination of spectroscopic monitoring (with UV–vis and ESI-MS) and DFT calculations indicates the preferential size-reduction on the corner Au atoms on the core surface and the terminal Au atoms on longer AunSn+1 staples. This study provides a reassessment on the electronic state of the Au21 structure and highlights the single electron transfer processes in cluster systems and thus the importance of the EPR analysis on the mechanistic issues

The Pivotal Radical Intermediate [Au₂₁(SR)₁₅]⁺ in the Ligand-Exchange-Induced Size-Reduction of [Au₂₃(SR)₁₆]⁻ to Au₁₆(SR)₁₂

The atomic precision of sub-nanometer-sized metal nanoclusters makes it possible to elucidate the kinetics of metal nanomaterials from the molecular level. Herein, the size reduction of an atomically precise [Au23(CHT)16]− (HCHT = cyclohexanethiol) cluster upon ligand exchange with HSAdm (1-adamantanethiol) has been reported. During the 16 h conversion of [Au23(CHT)16]− to Au16(SR)12, the neutral 6e Au21(SR)15, and its 1e-reduction state, i.e. the 5e, cationic radical, [Au21(SR)15]+, are active intermediates to account for the formation of thermodynamically stable Au16 products. The combination of spectroscopic monitoring (with UV–vis and ESI-MS) and DFT calculations indicates the preferential size-reduction on the corner Au atoms on the core surface and the terminal Au atoms on longer AunSn+1 staples. This study provides a reassessment on the electronic state of the Au21 structure and highlights the single electron transfer processes in cluster systems and thus the importance of the EPR analysis on the mechanistic issues

Association between fibrinolytic function makers and AF.

<p>A. Tissue-type plasminogen activator and AF; B. Plasminogen activator inhibitor-1 and AF. Forest plots of SMD and overall SMD with 95% CI between AF cases and controls. Black diamonds indicate the SMD, with the size of the square inversely proportional to its variance, and horizontal lines represent the 95% CI. The pooled results are indicated by the black hollow diamond. AF, atrial fibrillation; tPA, tissue-type plasminogen activator; PAI-1, plasminogen activator inhibitor-1; SMD, standardized mean difference.</p

Flow diagram of the literature search and study selection.

<p>Flow diagram of the literature search and study selection.</p

Association between platelet activation markers and AF.

<p>A. platelet count and AF; B. Mean platelet volume and AF; C. Platelet factor-4 and AF; D. β-thromboglobulin and AF; E. P-selectin and AF. Forest plots of SMD and overall SMD with 95% CI between AF cases and controls. Black diamonds indicate the SMD, with the size of the square inversely proportional to its variance, and horizontal lines represent the 95% CI. The pooled results are indicated by the black hollow diamond. AF, atrial fibrillation; MPV, mean platelet volume; PF-4, platelet factor-4; BTG, β-thromboglobulin; PAF, paroxysmal AF; PeAF, persistent AF; PtAF, permanent AF; CAF, chronic AF; SMD, standardized mean difference.</p

Summary results of meta-analysis by hemostatic markers.

<p>AF, atrial fibrillation; MPV, mean platelet volume; PF-4, platelet factor 4; BTG, β-thromboglobulin; P-sel, P-selectin; Fib, fibrinogen; TAT, thrombin—antithrombin; F1+2, prothombin fragments 1+2; AT- III, Antithrombin III; tPA, tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1; vWf, vonWillebrand factor; sTM, soluble thrombomodulin; SMD, standardized mean difference; CI, confidence interval.</p><p>Summary results of meta-analysis by hemostatic markers.</p