Visualization of the Eigen-structure Updating of Three-Dimensional Random Tensor

This image visualizes the structural relationship between the higher order singular value decomposition (HOSVD) of a three-dimensional random tensor (above) of size 20x15x10 and a partial three-dimensional tensor (below) of size 7x10x5, which is extracted from the original random tensor (above). The relative position of the new tensor within the old tensor is highlighted in yellow. Their higher order singular value decompositions are shown on the right, which consist of core tensors (red and blue), and two sets of loading matrices (shown in colored images). In this research in UIC, we discovered the structural relationship between the HOSVDs of those two tensors, and developed fast updating and downdating algorithms for re-calculating of HOSVDs. These algorithms are applicable to many areas of research involving tensor-form data. Specifically, we applied these algorithms in dynamic updating and downdating of video and motion trajectory databases

External Heavy-Atom Activated Phosphorescence of Organic Luminophores in a Rigid Fluid Matrix

Growing attention has been paid to pure organic room-temperature phosphorescence (RTP). Although an insufficient population and fast nonradiative decay of triplet excitons are avoided in recent endeavors, complicated synthesis and limited universality still hinder its development. Further, fluid RTP materials are more difficult to design because of faster nonradiative relaxation. Herein, a deep eutectic mixture of glucose and choline, a stable supercooled liquid at room temperature, is employed as a matrix. Direct transformation from commercial fluorescent dyes to RTP fluid is realized by doping without modifications. The excited triplet states are generated by an external heavy atom, while the rigid noncovalent network stabilizes them with both functions intrinsic to the liquid matrix. Modulation of matrix components also results in nearly white light emission of a single dye. This study presents a general strategy to design fluid RTP materials starting from the vast library of fluorophores

METTL14-mediated N6-methyladenosine modification of MAP2 in RPE-associated ocular diseases

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Visually Monitoring the Compactness of Polymer Matrixes Coded by Disparate Luminescence

The intrinsic property disclosure of polymer systems by visual monitoring of photoluminescence behaviors is of great value in fundamental interest and promising applications. Three novel polymer films were obtained by simply doping methyl 9,14-diphenyl-9,14-dihydrodibenzo­[a,c]­phenazine-11-carboxylate (DPC) with three polymer materials. The photoluminescence behaviors of these films represented diverse fluorescence emissions from light orange to blue, especially room-temperature phosphorescence (RTP) emissions with ultralong lifetime, attributing to various configurations of DPC molecules provided by distinct microscopic environments in three polymer systems. The rigidity and regularity of polymer systems would be visually reflexed by luminescence regulation and temperature responses. In addition, irregular distribution of distinct polymer systems could be specifically monitored by both fluorescence and phosphorescence behaviors when doping different polymer materials into one blend film

Visually Monitoring the Compactness of Polymer Matrixes Coded by Disparate Luminescence

The intrinsic property disclosure of polymer systems by visual monitoring of photoluminescence behaviors is of great value in fundamental interest and promising applications. Three novel polymer films were obtained by simply doping methyl 9,14-diphenyl-9,14-dihydrodibenzo­[a,c]­phenazine-11-carboxylate (DPC) with three polymer materials. The photoluminescence behaviors of these films represented diverse fluorescence emissions from light orange to blue, especially room-temperature phosphorescence (RTP) emissions with ultralong lifetime, attributing to various configurations of DPC molecules provided by distinct microscopic environments in three polymer systems. The rigidity and regularity of polymer systems would be visually reflexed by luminescence regulation and temperature responses. In addition, irregular distribution of distinct polymer systems could be specifically monitored by both fluorescence and phosphorescence behaviors when doping different polymer materials into one blend film

Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFR^WT and EGFR^T790M

A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells. Compounds 15–21 were showed to be more effective against the four tested cell lines than erlotinib. In particular, compound 16 was found to be the most potent counterpart as it was 5.55, 4.34, 5.04, and 7.18 times more active than erlotinib against MCF-7, HepG-2, HCT-116, and A549 cells, respectively. Compound 15 was revealed to be more active than doxorubicin against the four tested cell lines. Furthermore, the most potent cytotoxic compounds were studied further for their kinase inhibitory effects against EGFRWT and EGFRT790M using HTRF test. Compound 16 showed to be the most effective against both kinds of EGFR, with IC50 values of 0.10 and 4.02 µM, respectively. Compound 16 could effectively degrade EGFR protein through ubiquitination (Dmax = 96%) at 72 h in the tested cells.</p

Controllable Self-Assembling of Gold Nanorods via On and Off Supramolecular Noncovalent Interactions

5,15-Bis­(4-sulfonatophenyl)­porphyrin (<b>DPPS</b>) with a planar conjugated system and two negative charges was found to be able to engender the self-assembling of CTAB-<b>GNR</b>s due to the electrostatic interaction between <b>DPPS</b> and CTAB together with the π–π intermolecular interaction of <b>DPPS</b>, while its bulky supramolecular pseudo[3]­rotaxane included by β-cyclodextrin prevented such self-assembling due to the interruption of the above noncovalent interactions

Tunable Fluorescence and Room-Temperature Phosphorescence from Multiresponsive Pure Organic Copolymers

Stimuli-responsive polymers have received growing attention in the photochromic area of applied materials undoubtedly. It remains a great challenge to achieve multifunctional luminescence materials with a multitudinous stimuli response. Three color-convertible copolymers are obtained with the relative copolymerization of benzaldehyde, 2,5-dihydroxy terephthalate, spiropyran (SP), and acrylamide. The achieved solid powder could respond to light, temperature, as well as humidity upon the alternation of UV light and visible light irradiation. Multicolor conversions including white-light emission with CIE coordinates (0.33, 0.33) are also obtained reversibly owing to the photochromic nature of SP moiety. Furthermore, the energy transfers proposed in these photochromic copolymers are not limited to fluorescence energy transfer only, which are enriched by triplet energy transfer with long lifetimes. Corresponding properties and applications were also fully explored based on these copolymers

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

The high biocompatibility and excellent photostability of Au nanoclusters (AuNCs) make them stand out in the bioimaging of nanoparticles. However, the low quantum yield and inferior targeting ability of water-soluble AuNCs greatly limit their biological applications. In this study, we designed and synthesized multifunctional host polymers PolySC4AP and FGGC@AuNCs to fabricate PolySC4AP/FGGC@AuNC assemblies via a host–guest interaction based on SC4 (sulfonatocalix[4]­arene) and positively charged FGGC ligands (phenylalanine-glycine-glycine-cysteine). Owing to the host–guest assembly strategy and rigid polymer matrix, the quantum yield of FGGC@AuNCs was significantly promoted from 7.0 to 35.3%, accompanied by considerable morphological changes of FGGC@AuNCs. Moreover, PolySC4AP/FGGC@AuNCs could monitor the location of mitochondria along with R (Pearson’s correlation coefficients) value for the co-localization as high as 0.9605, which provided a novel strategy for targeted bioimaging with luminophore