6 research outputs found

    Transparent Polymeric Films Capable of Healing Millimeter-Scale Cuts

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    Transparent polymeric films have been successfully integrated with self-healing capabilities. However, these films can only heal damages in the scale of several to several tens of micrometers, thereby greatly limiting their practical applications. The present study reports the fabrication of transparent polymeric films capable of healing millimeter-scale cuts by incorporating hydrogen-bonding units into zwitterionic polymer films, which are cross-linked by electrostatic interactions. The intermolecular interactions in the resulting films are greatly reduced when the films absorb water as a result of the reversibility of hydrogen-bonding and electrostatic interactions, thereby promoting the flowability of the film materials. Thus, the transparent films can heal 7.9 mm wide cuts and recover their damaged transparency following exposure to water. Furthermore, owing to their strong binding affinity to water molecules, the healable transparent films can effectively clean up oil fouled on dry films following rinsing with water. The combination of hydrogen bonding and electrostatic interactions provides a new means of design for transparent films with enhanced healing capabilities and an extended service life

    Durable, Highly Electrically Conductive Cotton Fabrics with Healable Superamphiphobicity

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    Electrically conductive fabrics with liquid repellency and corrosive resistance are strongly desirable for wearable displays, biomedical sensors, and so forth. In the present work, highly electrically conductive and healable superamphiphobic cotton fabrics are fabricated by a solution-dipping method that involves (NH<sub>4</sub>)<sub>2</sub>PdCl<sub>4</sub>-catalyzed electroless deposition of Cu and the subsequent deposition of a mixture of fluorinated-decyl polyhedral oligomeric silsesquioxane (F-POSS) and 1<i>H</i>,1<i>H</i>,2<i>H</i>,2<i>H</i>-perfluorooctyltriethoxysilane (POTS) on cotton fabrics. Because of their superamphiphobicity, the resulting fabrics are self-cleaning and exhibit excellent resistance against corrosive acidic and basic solutions. The as-prepared fabrics have a sheet resistance of ‚ąľ0.33 ő©¬∑sq<sup>‚Äď1</sup> and show excellent electromagnetic interference shielding and electrothermal heating ability. Because of the preserved F-POSS and POTS molecules, the fabrics can conveniently and repeatedly restore the loss of superamphiphobicity by applying a low voltage of 1.0 V or heating the fabrics at 135 ¬įC to facilitate the migration of the preserved F-POSS and POTS to the surface of cotton fabrics. The integration of healable superamphiphobicity into the Cu-coated fabrics generates multiple functional cotton fabrics with excellent conductivity, electromagnetic interference shielding, self-cleaning ability, and significantly enhanced durability

    Additional file 1: of SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT

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    Figure S1. GSK650394 impairs DU145 cells migration capability.Wound healing assays of DU145 cells treated with DMSO or 20¬†őľM GSK650394. Phase-contrast images were acquired at 0 and 24¬†h after scratching and representative images of three independent experiments are shown. The wound healing area was analyzed by using ImageJ software and the corresponding data, relative to 0¬†h, expressed in the graph. (DOCX 961 kb

    Obesity induced by chronic salt restriction: Evaluation of hormonal profile and appetite in Wistar rats.

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    Em nosso laborat√≥rio foi demonstrado que ratos submetidos √† restri√ß√£o cr√īnica de sal na dieta apresentaram maior peso corp√≥reo (PC), menor sensibilidade √† insulina e altera√ß√Ķes press√≥ricas em compara√ß√£o com ratos submetidos √† sobrecarga cr√īnica de sal na dieta. No presente estudo, o objetivo foi avaliar alguns mecanismos de obesidade e altera√ß√Ķes hormonais associados √† dieta hiposs√≥dica. Foram utilizados ratos Wistar machos submetidos √† dieta hipo (HO: 0,15% NaCl), normo (NO: 1,27% NaCl) ou hipers√≥dica (HR: 7,94% NaCl) desde o desmame at√© 12 semanas de idade. Nestes animais foram realizadas medidas de press√£o arterial (PA), freq√ľ√™ncia card√≠aca (FC), consumo de ra√ß√£o, PC, perfil dos horm√īnios [leptina (LEP), GH, insulina (INSh - anticorpo anti-insulina humana), T3, T4 e TSH] e decaimento da 125I-insulina (DEC-INS). O consumo de ra√ß√£o foi avaliado durante sete dias consecutivos com um (1G) ou quatro (4G) ratos por gaiola de pl√°stico e com um rato por gaiola metab√≥lica (1GM). O PC tamb√©m foi medido neste per√≠odo. Glicemia (GLI) e insulinemia (INSr - anticorpo anti-insulina de rato) basais foram quantificadas antes da realiza√ß√£o do estudo do DEC-INS. Para avaliar o DEC-INS, foi injetado 1mCi de 125I-insulina humana pelo cateter implantado na veia jugular, ap√≥s 6 a 8 horas de jejum fisiol√≥gico. As amostras de sangue foram coletadas pelo cateter implantado na car√≥tida a cada 30 segundos durante 2 minutos e depois a cada 1 minuto at√© 10 minutos de experimento. Os resultados obtidos demonstraram que ratos submetidos √† dieta HR apresentaram maior PA em compara√ß√£o a ratos em dieta NO e HO. Os ratos submetidos √† dieta HO apresentaram menor FC card√≠aca em rela√ß√£o ao grupo NO. A avalia√ß√£o de ingest√£o alimentar revelou que ratos em dieta HR consumiram maiores quantidades de ra√ß√£o (1G e 4G) em compara√ß√£o com ratos em dieta NO e HO. O grupo HO apresentou maior PC em compara√ß√£o com os grupos de ratos NO e HR. Os ratos em dieta HR ou HO apresentaram n√≠veis diminu√≠dos de LEP em compara√ß√£o com ratos submetidos √† dieta NO. Os ratos que receberam dieta HO apresentaram n√≠veis elevados de INSr em compara√ß√£o com ratos em dieta HR e NO. Os ratos em dieta HR apresentaram n√≠veis elevados de T4 total e n√≠veis reduzidos de TSH em compara√ß√£o com animais em dieta NO e HO. INSr e GLI basais foram maiores nos ratos em dieta HO do que nos ratos que receberam dieta HR e NO. O DEC-INS (decaimento exponencial) foi mais r√°pido no grupo HR demonstrado por meio de menor meia-vida da 125I-insulina. Os resultados sugerem que maior PC nos ratos sob restri√ß√£o salina cr√īnica √© devido a maior efici√™ncia metab√≥lica (maior PC e menor consumo de dieta) que pode estar relacionada com altera√ß√Ķes hormonais e com a dieta HO. Palavras-chave: Press√£o arterial, sal, s√≥dio, ingest√£o alimentar e perfil hormonal.Previous studies from our laboratory have shown that chronic salt restriction decreases blood pressure, increases insulin resistance, and body weight (BW) in Wistar rats. The aim of this study was to evaluate some mechanisms of obesity and hormonal alterations associated with chronic salt restriction. Male Wistar rats were fed a low (LSD: 0,15% NaCl), normal (NSD: 1,27% NaCl), or high salt diet (HSD: 7,94% NaCl) from weaning. At the 12th week of age, tail-cuff blood pressure (TCBP), intra arterial blood pressure (BP), heart rate ((HR), food intake, BW, hormonal levels [leptin (LEP), growth hormone (GH), insulin (INSh - antibody anti-human insulin), T3, T4 and TSH] and 125I insulin decay study (DECAY-INS) were measured. To evaluate the food intake and body weight, each dietary group was divided in 3 subgroups, according to housing conditions: one (1C) or four (4C) rats per cage and one rat per metabolic cage (1MC) for daily food consumption and BW determinations during 7 days. Fasting plasma glucose (GLU) and insulin (INSr - antibody anti-rat insulin) were measured before the DECAY-INS. To evaluate the DECAY-INS, 1mCi human 125I-insulin was injected through the jugular catheter after 6-8 hours of food restriction. Blood samples were withdrawn through the carotid catheter every 30 sec during 2min, and in sequence, every 1 min for additional 10 minutes. 125Iinsulin was determined by RIA for human insulin. Rats on HSD had higher intra arterial BP and TCBP compared to rats on NSD and LSD. Heart rate was lower on LSD than on NSD. In all housing conditions, BW was higher on LSD than on NSD and HSD. Food intake was higher on HSD (1C and 4C) than on NSD and LSD. Plasma GH and LEP were higher on NSD than on the 68 other two groups. Plasma INSh was higher in LSD compared to HSD and NSD rats. Plasma total T4 was higher on HSD than on the NSD and LSD, TSH was lower on HSD than on NSD and HSD, and T3 was not different among all groups. Fasting GLU and INSr were higher on LSD compared to HSD and NSD rats. The exponential insulin decay was faster on HSD demonstrated by a lower 125I-INS half-life. These results suggest that obesity in rats on chronic LSD is due to a higher metabolic efficiency (higher body weight and lower diet consumption), that may be related to the hormonal consequences of LSD. Key Words: blood pressure, salt, sodium, food intake and hormonal profile

    Carbon Nitride Nanothread Crystals Derived from Pyridine

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    Carbon nanothreads are a new one-dimensional sp<sup>3</sup> carbon nanomaterial. They assemble into hexagonal crystals in a room temperature, nontopochemical solid-state reaction induced by slow compression of benzene to 23 GPa. Here we show that pyridine also reacts under compression to form a well-ordered sp<sup>3</sup> product: C<sub>5</sub>NH<sub>5</sub> carbon nitride nanothreads. Solid pyridine has a different crystal structure from solid benzene, so the nontopochemical formation of low-dimensional crystalline solids by slow compression of small aromatics may be a general phenomenon that enables chemical design of properties. The nitrogen in the carbon nitride nanothreads may improve processability, alters photoluminescence, and is predicted to reduce the bandgap

    Carbon Nitride Nanothread Crystals Derived from Pyridine

    No full text
    Carbon nanothreads are a new one-dimensional sp<sup>3</sup> carbon nanomaterial. They assemble into hexagonal crystals in a room temperature, nontopochemical solid-state reaction induced by slow compression of benzene to 23 GPa. Here we show that pyridine also reacts under compression to form a well-ordered sp<sup>3</sup> product: C<sub>5</sub>NH<sub>5</sub> carbon nitride nanothreads. Solid pyridine has a different crystal structure from solid benzene, so the nontopochemical formation of low-dimensional crystalline solids by slow compression of small aromatics may be a general phenomenon that enables chemical design of properties. The nitrogen in the carbon nitride nanothreads may improve processability, alters photoluminescence, and is predicted to reduce the bandgap
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