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Additional file 4: Table S4. Differentially expressed proteins between “P0” and “F3”

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Additional file 2: Table S2. Composition of total raw reads and statistical results of samples mapped to gene and genome

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Additional file 5: Table S5. Model summaries for the discrimination between the Pi-replete and Pi-limited samples from LC-MS data for metabolomic analysis

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Additional file 1: Table S1. Primers used in this study

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Additional file 3: Table S3. Differentially expressed genes between “P0” and “F3”

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Additional file 7: Figure S1. Comparative metabolomic analyses of R. toruloides samples prepared under Pi-limited (P0) and Pi-replete (F3) conditions. a Total ion chromatogram of quality control (QC) sample (positive). b Total ion chromatogram of QC sample (negative). c Changes of some cellular nucleoside derivatives and bases. Figure S2. Metabolomic analysis of R. toruloides during phosphate-limitation. a Score plot of PCA in P0 vs F3 (positive). b Score plot of PLS-DA in P0 vs F3 (positive). c Sorting plot of PLS-DA in P0 vs F3 (positive). d Score plot of OPLS-DA in P0 vs F3 (positive). Figure S3. Metabolomic analysis of R. toruloides during phosphate-limitation. a Score plot of PCA in P0 vs F3 (negative). b Score plot of PLS-DA in P0 vs F3 (negative). c Sorting plot of PLS-DA in P0 vs F3 (negative). d Score plot of OPLS-DA in P0 vs F3 (negative)

Additional candidate risk variants located within 1 Mb from the eight original risk markers.

<p>Additional candidate risk variants located within 1 Mb from the eight original risk markers.</p

Pedigrees of the families tested for variant segregation.

<p>Mutation carriers and non-carriers are indicated with red and green squares, respectively. Diagnosis and age (when available) is indicated under each individual in bold text, and sample IDs in Italic. CRC, colorectal cancer; HP, hyperplastic polyp; GaCa, gastric cancer; TVAHD, tubulovillous adenoma with high degree dysplasia; BrCa, breast cancer; TVA, tubulovillous adenoma; SALD, serrated adenomas with low degree dysplasia.</p

Comparison of previously reported risk variants [18] to the current study.

<p>Comparison of previously reported risk variants [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0193547#pone.0193547.ref018" target="_blank">18</a>] to the current study.</p

Candidate risk variants identified in GWAS confirmed by Sanger sequencing.

<p>Candidate risk variants identified in GWAS confirmed by Sanger sequencing.</p