Iridium(III)-Catalyzed C–H Amidation of Nitrones with Dioxazolones

Various amidated nitrones were efficiently achieved through Ir­(III)-catalyzed direct C–H amidation of nitrones with good to excellent yields and tolerance of broad functional groups. This reaction smoothly proceeded at room temperature in the absence of acid or base in a short reaction time. Carbon dioxide was generated as the sole byproduct, thus providing an environmentally benign amidation process. The title products could be efficiently transformed to substituted benzisoxazoline

Visible-Light-Promoted Direct C3‑H Cyanomethylation of 2<i>H</i>‑Indazoles

The efficient visible-light-promoted cyanomethylation of 2H-indazoles in the presence of Ir­(ppy)3 as the photocatalyst and bromoacetonitrile as the cyanomethyl radical source was achieved under mild conditions, providing a series of C3-cyanomethylated derivatives in good yields

Regioselective Palladium-Catalyzed Phosphonation of Coumarins with Dialkyl <i>H</i>‑Phosphonates via C–H Functionalization

A novel Pd(II)-catalyzed dehydrogenative cross-coupling reaction between coumarins and H-phosphonates has been developed to give the corresponding 3-phosphonated products in moderate to good yields with high selectivity

Preparation of 3‑Acyl-4-arylcoumarins via Metal-Free Tandem Oxidative Acylation/Cyclization between Alkynoates with Aldehydes

A new and efficient metal-free tandem acylation/cyclization of alkynoates with aldehydes was developed for the synthesis of 3-acyl-4-arylcoumarins. The reaction was achieved by the addition of acyl radical to alkynes and a C–H bond functionalization to form two new C–C bonds simultaneously

Regioselective Palladium-Catalyzed Phosphonation of Coumarins with Dialkyl <i>H</i>‑Phosphonates via C–H Functionalization

A novel Pd(II)-catalyzed dehydrogenative cross-coupling reaction between coumarins and <i>H</i>-phosphonates has been developed to give the corresponding 3-phosphonated products in moderate to good yields with high selectivity

Preparation of 3‑Acyl-4-arylcoumarins via Metal-Free Tandem Oxidative Acylation/Cyclization between Alkynoates with Aldehydes

A new and efficient metal-free tandem acylation/cyclization of alkynoates with aldehydes was developed for the synthesis of 3-acyl-4-arylcoumarins. The reaction was achieved by the addition of acyl radical to alkynes and a C–H bond functionalization to form two new C–C bonds simultaneously

Silver-Catalyzed Synthesis of 3‑Phosphorated Coumarins via Radical Cyclization of Alkynoates and Dialkyl <i>H</i>‑Phosphonates

Ag2CO3-catalyzed difunctionalization of alkynes via a radical phosphonation and C–H functionalization tandem process was developed to synthesize various 3-phosphonated coumarins in moderate to high yields with high regioselectivity. A catalytic amount of cheap and nontoxic silver salt was employed in the domino C–P and C–C formation of alkynoates for the first time. Mechanistic studies indicate that the reaction pathway might proceed via the generation and cyclization of a phosphonated vinyl radical intermediate

Silver-Catalyzed Synthesis of 3‑Phosphorated Coumarins via Radical Cyclization of Alkynoates and Dialkyl <i>H</i>‑Phosphonates

Ag₂CO₃-catalyzed difunctionalization of alkynes via a radical phosphonation and C–H functionalization tandem process was developed to synthesize various 3-phosphonated coumarins in moderate to high yields with high regioselectivity. A catalytic amount of cheap and nontoxic silver salt was employed in the domino C–P and C–C formation of alkynoates for the first time. Mechanistic studies indicate that the reaction pathway might proceed via the generation and cyclization of a phosphonated vinyl radical intermediate